Cholestatic effects of the K+ channel blockers Ba2+ and TEA occur through different pathways in the rat liver

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 276, Issue 1 39-1, 1999, Pages

  Hill, Ceredwyn Elizabeth ^a,b   Jacques, Jody Elisabeth ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b HOTEL DIEU HOSPITAL   (Canada)

Author keywords

Basolateral; Bile acid independent; Hepatocyte; Tetraethylammonium

Indexed keywords

4 AMINOPYRIDINE; BARIUM ION; BILE ACID; CESIUM; GLUTATHIONE; IBERIOTOXIN; PAXILLINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; QUINIDINE; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; BILE DUCT; BILE FLOW; BILIARY EXCRETION; CONTROLLED STUDY; INTRAHEPATIC CHOLESTASIS; ISOLATED LIVER; LIVER PERFUSION; MALE; NONHUMAN; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT;

EID: 0032948283     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.1.g43     Document Type: Article

References (30)

1. Ballatori, N., and A. T. Truong. Glutathione as a primary osmotic driving force in hepatic bile formation. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G617-G624, 1992.
2. Ballatori, N., and A. T. Truong. Multiple canalicular transport mechanisms for glutathione S-conjugates. J. Biol. Chem. 270: 3594-3601, 1995.
3. Bear, C. E., J. S. Davison, and E. A. Shaffer. Intracellular pH influences the resting membrane potential of isolated rat hepatocytes. Biochim. Biophys. Acta 944: 113-120, 1988.
4. Breit, S., H.-A. Kolb, H. Apfel, C. Haberland, M. Schmitt, D. Haussinger, J. Graf, and F. Lang. Regulation of ion channels in hepatocytes. Pflügers Arch. 435: 203-210, 1998.
5. Bruck, R., A. Benedetti, M. Strazzabosco, and J. L. Boyer. Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G347-G353, 1993.
6. Burgess, G. M., M. Claret, and D. H. Jenkinson. Effects of quinine and apamine on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells. J. Physiol. (Lond.) 317: 67-90, 1981.
7. Erlinger, S. Bile secretion. Br. Med. Bull. 48: 860-876, 1992.
8. + conductance in cultured rat hepatocytes. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G961-G968, 1989.
9. Gorboulev, V., J. C. Ulzheimer, A. Akhoundova, I. Ulzheimer-Teuber, U. Karbach, S. Quester, C. Baumann, F. Lang, A. E. Busch, and H. Koepsell. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16: 871-881, 1997.
10. Graf, J. Canalicular bile salt-independent bile formation: concepts and clues from electrolyte transport in rat liver. Am. J. Physiol. 244 (Gastrointest. Liver Physiol. 7): G233-G246, 1983.
11. Graf, J., R. M. Henderson, B. Krumpholz, and J. L. Boyer. Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets. J. Membr. Biol. 95: 241-254, 1987.
12. Griffith, O. W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106: 207-212, 1980.
13. + fluxes in the isolated perfused rat liver: characterization by ion transport inhibitors. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G357-G363, 1989.
14. + fluxes. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G563-G569, 1989.
15. Haussinger, D., C. Hallbrucker, N. Saha, F. Lang, and W. Gerok. Cell volume and bile acid excretion. Biochem. J. 288: 681-689, 1992.
16. Henderson, R. M., J. Graf, and J. L. Boyer. Inward-rectifying potassium channels in rat hepatocytes. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G1028-G1035, 1989.
17. + channel blockers. J. Physiol. (Lond.) 453: 33-44, 1992.
18. Hill, C. E., J. W. Myers, and D. C. Pon. Involvement of intrahepatic innervation in caesium-induced haemodynamic oscillations in the rat liver. J. Physiol. (Lond.) 460: 69-78, 1993.
19. Hill, C. E., and D. C. Pon. The inwardly rectifying potassium current of embryonic chick hepatocytes. J. Membr. Biol. 144: 249-255, 1995.
20. + channels in short-term cultured hepatocytes. J. Cell. Physiol. 171: 87-94, 1997.
21. Hill, C. E., J. S. Pryor, M. S. Olson, and A. P. Dawson. Potassium mediated stimulation of glycogenolysis. J. Biol. Chem. 262: 6623-6627, 1987.
22. Kwon, Y., R. D. Lee, and M. E. Morris. Hepatic uptake of choline in rat liver basolateral and canalicular membrane vesicle preparations. J. Pharmacol. Exp. Ther. 279: 774-781, 1996.
23. Mosely, R. H., S. M. Jarose, and P. Permoad. Organic cation transport by rat liver plasma membrane vesicles: studies with tetraethylammonium. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G775-G785, 1992.
24. Mosely, R. H., H. Takeda, and L. J. Zugger. Choline transport in rat liver basolateral plasma membrane vesicles. Hepatology 24: 192-197, 1996.
25. Myers, N. C., S. Grune, H. L. Jameson, and M. S. Anwer. cGMP stimulates bile acid-independent bile formation and biliary bicarbonate excretion. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G418-G424, 1996.
26. Sellinger, M., and J. L. Boyer. Physiology of bile secretion and cholestasis. Prog. Liver Dis. 9: 237-259, 1990.
27. St. Pierre, M. V., J.-F. Dufour, and I. M. Arias. Stimulation of bile acid independent bile flow with bromo-cyclic guanosine monophosphate. Hepatology 24: 1487-1491, 1996.
28. + channel is present in guinea-pig but lacking in rat hepatocytes. Jpn. J. Physiol. 42: 415-430, 1992.
29. Van Dyke, R. W., J. E. Stephens, and B. F. Scharschmidt. Effects of ion substitution on bile acid-dependent and -independent bile formation by rat liver. J. Clin. Invest. 70: 505-517, 1982.
30. Waldegger, S., F. Beisse, H. Apfel, S. Breit, H.-A. Kolb, D. Haussinger, and F. Lang. Electrophysiological effects of progesterone on hepatocytes. Biochim. Biophys. Acta 1266: 186-190, 1995.