Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin

Journal of Cell Science

Volumn 112, Issue 6, 1999, Pages 895-904

  Grönholm, Mikaela ^a   Sainio, Markku ^a   Zhao, Fang ^a   Heiska, Leena ^a   Vaheri, Antti ^a   Carpén, Olli ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cytoskeleton; ERM protein; Ezrin; Merlin; Neurofibromatosis 2

Indexed keywords

COMPLEMENTARY DNA; CYTOSKELETON PROTEIN; EZRIN; MERLIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN COS1; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DNA TRANSFECTION; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE;

ANIMALS; CLONING, MOLECULAR; COS CELLS; CYTOSKELETAL PROTEINS; CYTOSKELETON; GENES, NEUROFIBROMATOSIS 2; GLIOMA; HUMANS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; NEUROFIBROMIN 2; PHOSPHOPROTEINS; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032947605     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Andreoli, C., Martin, M., Le Borgne, R., Reggio, H. and Mangeat, P. (1994). Ezrin has properties to self-associate at the plasma membrane. J. Cell Sci. 107, 2509-2521.
2. Berryman, M., Gary, R. and Bretscher, A. (1995). Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. J. Cell Biol. 131, 1231-1242.
3. Bianchi, A. B., Hara, T., Ramesh, V., Gao, J., Klein-Szanto, A. J., Morin, F., Menon, A. G., Trofatter, J. A., Gusella, J. F., Seizinger, B. R., et al. (1994). Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat. Genet. 6, 185-192.
4. Böhling, T., Turunen, O., Jääskeläinen, J., Carpén, O., Sainio, M., Wahlström, T., Vaheri, A. and Haltia, M. (1996). Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors. Am. J. Pathol. 148, 367-373.
5. Bretscher, A. (1989). Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor. J. Cell Biol. 108, 921-930.
6. den Bakker, M. A., Riegman, P. H., Hekman, R. A., Boersma, W., Janssen, P. J., van der Kwast, T. H. and Zwarthoff, E. C. (1995). The product of the NF2 tumour suppressor gene localizes near the plasma membrane and is highly expressed in muscle cells. Oncogene 10, 757-763.
7. Funayama, N., Nagafuchi, A., Sato, N., Tsukita, Sa. and Tsukita, Sh. (1991). Radixin is a novel member of the band 4. I family. J. Cell Biol. 115, 1039-1048.
8. Gary, R. and Bretscher, A. (1993). Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins. Proc. Nat. Acad. Sci. USA 90, 10846-10850.
9. Gary, R. and Bretscher, A. (1995). Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol. Biol. Cell 6, 1061-1075.
10. Gonzalez-Agosti, C., Xu, L., Pinney, D., Beauchamp, R., Hobbs, W., Gusella, J. and Ramesh, V. (1996). The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene 13, 1239-1247.
11. Gould, K. L., Bretscher, A., Esch, F. S. and Hunter, T. (1989). cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4. I. EMBO J. 8, 4133-4142.
12. Gyuris, J., Golemis, E., Chertkov, H. and Brent, R. (1993). Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75, 791-803.
13. Harshman, K. D., Scott Moye-Rowley, W. and Parker, C. S. (1988). Transcriptional activation by the SV 40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4. Cell 53, 321-330.
14. Heiska, L., Alfthan, K., Grönholm, M., Vilja, P., Vaheri, A. and Carpén, O. (1998). Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 273, 21893-21900.
15. Helander, T. S., Carpén, O., Turunen, O., Kovanen, P. E., Vaheri, A. and Timonen, T. (1996). ICAM-2 redistributed by ezrin as a target for killer cells. Nature 382, 265-268.
16. Henry, M. D., Gonzalez-Agosti, C. and Solomon, F. (1995). Molecular dissection of radixin: distinct and interdependent functions of the amino-and carboxy-terminal domains. J. Cell Biol. 129, 1007-1022.
17. Hirao, M., Sato, N., Kondo, T., Yonemura, S., Monden, M., Sasaki, T., Takai, Y., Tsukita, Sh. and Tsukita, Sa. (1996). Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J. Cell Biol. 135, 37-51.
18. Huang, L. Q., Ichimaru, E., Pestonjamasp, K., Cui, X. M., Nakamura, H., Lo, G. Y. H., Lin, F. I. K., Luna, E. J. and Furthmayr, H. (1998). Merlin differs from moesin in bindint to F-actin and in its intra-and intermolecular interactions. Biochem. Biophys. Res. Commun. 248, 548-553.
19. Jooss, K. U. and Muller, R. (1995). Deregulation of genes encoding microfilament-associated proteins during Fos-induced morphological transformation. Oncogene 10, 603-608.
20. Kaul, S. C., Mitsui, Y., Komatsu, Y., Reddel, R. R. and Wadhwa, R. (1996). A highly expressed 81 kDa protein in immortalized mouse fibroblast: its proliferative function and identity with ezrin. Oncogene 13, 1231-1237.
21. Lamb, R. F., Ozanne, B. W., Roy, C., McGarry, L., Stipp, C., Mangeat, P. and Jay, D. G. (1997). Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts. Curr. Biol. 7, 682-688.
22. Lankes, W. T. and Furthmayr, H. (1991). Moesin: a member of the protein 4. 1-talin-ezrin family of proteins. Proc. Nat. Acad. Sci. USA 88, 8297-8301.
23. Louis, D. N., Ramesh, V. and Gusella, J. F. (1995). Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol. 5, 163-172.
24. Lutchman, M. and Rouleau, G. (1995). The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells. Cancer Res. 55, 2270-2274.
25. Mackay, D. J. G., Esch, F., Furthmayr, H. and Hall, A. (1997). Rho-and Rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for Ezrin/Radixin/Moesin proteins. J. Cell Biol. 138, 927-938.
26. Magendantz, M., Henry, M. D., Lander, A. and Solomon, F. (1995). Interdomain interactions of radixin in vitro. J. Biol. Chem. 270, 25324-25327.
27. Martin, M., Andreoli, C., Sahuquet, A., Montcourrier, P., Algrain, M. and Mangeat, P. (1995). Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain. J. Cell Biol. 128, 1081-1093.
28. Martin, M., Roy, C., Montcourrier, P., Sahuquet, A. and Mangeat, P. (1997). Three determinants in ezrin are responsible for cell extension activity. Mol. Biol. Cell 8, 1543-1557.
29. + exchange, is a common interactor for merlin and ERM (MERM) proteins. J. Biol. Chem. 273, 1273-1276.
30. Pestonjamasp, K., Amieva, M. R., Strassel, C. P., Nauseef, W. M., Furthmayr, H. and Luna, E. (1995). Moesin, ezrin, and p205 are actinbinding proteins associated with neutrophil plasma membranes. Mol. Biol. Cell 6, 247-259.
31. Raghuraman, M., Brewer, B. and Fangman, W. (1994). Activation of a yeast replication origin near a double-stranded DNA break. Genes Dev. 8, 554-562.
32. Reczek, D., Berryman, M. and Bretscher. A. (1997). Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J. Cell Biol. 139, 169-179.
33. Rouleau, G. A., Merel, P., Lutchman, M., Sanson, M., Zucman, J., Marineau, C., Hoang-Xuan, K., Demczuk, S., Desmaze, C., Plougastel, B., et al. (1993). Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363, 515-521.
34. Roy, C., Martin, M. and Mangeat, P. (1997). A dual involvement of the amino-terminal domain of ezrin in F-and G-actin binding. J. Biol. Chem. 272, 20088-20095.
35. Sainio, M., Zhao, F., Heiska, L., Turunen, O., den Bakker, M., Zwarthoff, E., Lutchman, M., Rouleau, G. A., Jääskeläinen, J., Vaheri, A., et al. (1997). Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J. Cell Sci. 110, 2249-2260.
36. Samson, M.-L., Jackson-Grusby, L. and Brent, R. (1989). Gene activation and DNA binding by Drosophila Ubx and abd-A proteins. Cell 57, 1045-1052.
37. Scoles, D. R., Huynh, D. P., Morcos, P. A., Coulsell, E. R., Robinson, N. G. G., Tamanoi, F. and Pulst, S. M. (1998). Neurofibromatosis 2 tumour suppressor schwannomin interacts with beta-II-spectrin. Nat. Genet. 18, 354-359.
38. Shaw, R. J., Mcclatchey, A. I. and Jacks, T. (1998). Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J. Biol. Chem. 273, 7757-7764.
39. Sherman, L., Xu, H. M., Geist, R. T., Saporito-Irwin, S., Howells, N., Ponta, H., Herrlich, P. and Gutmann, D. H. (1997). Interdomain binding mediates tumor growth suppression by the NF2 gene product. Oncogene 15, 2505-2509.
40. Stemmer-Rachamimov, A. O., Xu, L., Gonzalez-Agosti, C., Burwick, J. A., Pinney, D., Beauchamp, R., Jacoby, L. B., Gusella, J. F., Ramesh, V. and Louis, D. N. (1997). Universal absence of merlin, but not other ERM family members, in schwannomas. Am. J. Pathol. 151, 1649-1654.
41. Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, Sa. and Tsukita, Sh. (1994). Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J. Cell Biol. 125, 1371-1384.
42. Trofatter, J. A., MacCollin, M. M., Rutter, J. L., Murrell, J. R., Duyao, M. P., Parry, D. M., Eldridge, R., Kley, N., Menon, A. G., Pulaski, K., et al. (1993). A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72, 791-800.
43. Tsukita, Sa., Yonemura, S. and Tsukita, Sh. (1997). ERM proteins: head-to-tail regulation of actin-plasma membrane interaction. Trends Biochem. Sci. 22, 53-58.
44. Turunen, O., Winqvist, R., Pakkanen, R., Grzeschik, K. H., Wahlström, T. and Vaheri, A. (1989). Cytovillin, a microvillar Mr 75, 000 protein. cDNA sequence, prokaryotic expression and chromosomal localization. J. Biol. Chem. 264, 16727-16732.
45. Turunen, O., Wahlström, T. and Vaheri, A. (1994). Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J. Cell Biol. 126, 1445-1453.
46. Turunen, O., Sainio, M., Jääskeläinen, J., Carpén, O. and Vaheri, A. (1998). Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein. Biochim. Biophys. Acta 1387, 1-16.
47. Vaheri, A., Carpén, O., Heiska, L., Helander, T. S., Jääskeläinen, J., Majander-Nordenswan, P., Sainio, M., Timonen, T. and Turunen, O. (1997). The ezrin protein family: membrane-cytoskeleton interactions and disease associations. [review] [69 refs]. Curr. Opin. Cell Biol. 9, 659-666.
48. Westermark, B. (1973). Determinants for the establishment of permanent tissue culture lines from human gliomas. Int. J. Cancer 12, 438-451.
49. Xu, H. M. and Gutmann, D. H. (1998). Merlin differentially associates with the microtubule and actin cytoskeleton. J. Neurosci. Res. 51, 403-415.
50. Yonemura, S., Hirao, M., Doi, Y., Takahashi, N., Kondo, T., Tsukita, Sa. and Tsukita, Sh. (1998). Ezrin/Radixin/Moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J. Cell Biol. 140, 885-895.