Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats

Lipids

Volumn 34, Issue 3, 1999, Pages 269-273

  Uchida, Kiyohisa ^a,b,d   Satoh, Takashi ^a   Narushima, Seiko ^b   Itoh, Kikuji ^b   Takase, Haruto ^a   Kuruma, Kazuo ^a   Nakao, Hiroyuki ^a   Yamaga, Nobuo ^c   Yamada, Kazuo ^c  

^a SHIONOGI AND CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d Cell Research Foundation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLIC ACID; COPROSTEROL; STEROL;

ARTICLE; BACTERIAL COUNT; BILE ACID METABOLISM; BIOTRANSFORMATION; CHEMICAL MODIFICATION; CLOSTRIDIUM; ESCHERICHIA COLI; LIPID COMPOSITION; NONHUMAN; RAT; STEROL METABOLISM;

BACTERIA (MICROORGANISMS); CLOSTRIDIA; CLOSTRIDIUM; ESCHERICHIA; ESCHERICHIA COLI; POSIBACTERIA; RATTUS NORVEGICUS; RODENTIA;

EID: 0032947555     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-999-0363-y     Document Type: Article

References (21)

1. Groh, H., Schade, K., and Hlejrhold-Schubert, C. (1993) Steroid Metabolism with Intestinal Microorganisms, J. Basic Microbiol. 33, 59-72.
2. Jonsson, G., Midtvedt, A.-C., Norman, A., and Midtvedt, T. (1995) Intestinal Microbial Bile Acid Transformation in Healthy Infants, J. Pediatr. Gastroenterol. Nutr. 20, 394-402.
3. Hylemon, P.B., and Glass, T.L. (1983) Biotransformation of Bile Acids and Cholesterol by the Intestinal Microflora, in Human Intestinal Microflora in Health and Disease (Hentges, D.J., ed.) pp. 189-213, Academic Press, New York.
4. Hirano, S., Nakama, R., Tamaki, M., Masuda, N., and Oda, H. (1981) Isolation and Characterization of Thirteen Intestinal Microorganisms Capable of 7α-Dehydroxylating Bile Acids, April. Environ. Microbiol. 41, 737-745.
5. Takamine, E., and Imamura, T. (1995) Isolation and Characterization of Bile Acid 7-Dehydroxylating Bacteria from Human Feces, Microbiol. Immunol. 39, 11-18.
6. Archer, R.H. Maddox, I.S., and Chong, R. (1982) Transformation of Cholic Acid by Clostridium bifermentans, J. Appl. Bacteriol. 52, 49-56.
7. Stellwag, E.J., and Hylemon, P.B. (1979) 7α-Dehydroxylation of Cholic Acid and Cheno-deoxycholic Acid by Clostridium leptum, J. Lipid Res. 20, 325-333.
8. Edenharder, R., and Slemrova, J. (1976) The Significance of the Bacterial Steroid Degradation for the Etiology of Large Bowel Cancer. IV. Deconjugation of Glycocholic Acid, Oxidation and Reduction of Cholic Acid by Saccharolytic Bacteroides Species, Zentralbl. Bakteriol. (Orig. B) 162, 350-373.
9. Midtvedt, T., and Norman, A. (1967) Bile Acid Transformation by Microbial Strains Belonging to Genera Found in Intestinal Contents, Acta Pathol. Microbiol. Scand. 71, 629-638.
10. Hirano, S., and Masuda, N. (1982) Enhancement of the 7α-Dehydroxylase Activity of a Gram-Positive Anaerobe by Bacteroides and Its Significance in the 7-Dehydroxylation of Ursodeoxycholic Acid, J. Lipid. Res. 23, 1152-1158.
11. Hylemon, P.B., Cacciapuotic, A.F., White, B.A., Whitehead, T.R., and Fricke, R.J. (1980) 7α-Dehydroxylation of Cholic Acid by Cell-free Extracts of Eubacterium Species V.P.I. 12708, Am. J. Clin. Nutr. 33, 2507-2510.
12. 22-β-Muricholic Acid in Monoassociated Rats and Conventional Rats, Lipids 29, 289-296.
13. Kanamura, M. (1982) Experimental Studies on Bile Acid Absorption and Bile Acid Metabolism, Jpn. J. Surg. 83, 677-690 (in Japanese).
14. Ohishi, I. (1986) Effect of Total Colectomy and Ileoproctostomy on Bile Acid Metabolism in Rats, Acta Medico Hyogoensia 11, 13-31 (in Japanese).
15. 5-Steroid-and Fatty Acid-Reducing Activity of the Rat Intestinal Microflora, J. Nutr. 102. 1501-1512.
16. Ito, K,. and Mitsuoka, T. (1985) Characterization of Clostridia Isolated from Feces of Limited Flora Mice and Their Effect on Caecal Size When Associated with Germ-free Mice, Lab. Animals 19, 111-118.
17. Benno, Y., Shiragami, N., Uchida, K., Yoshida, T., and Mitsuoka, T. (1986) Effect of Moxalactam on Human Fecal Microflora, Antimicrob. Agents Chemother. 29, 175-178.
18. Goto, J., Hasegawa, H., Kato, H., and Nambara, T. (1978) A New Method for Simultaneous Determination of Bile Acids in Human Bile Without Hydrolysis, Clin. Chim. Acta 87, 141-147.
19. Kuruma, K., Morioka, Y., Sasakura, K., Igimi, H., and Uchida, K. (1996) Determination of Sulfate-Conjugated 3β-Hydroxy Bile Acid in Urine by HPLC with Postcolumn Fluorescent Detection Using an Immobilized β-Hydroxysteroid Dehydrogenase Column, Anal. Sci. 12, 847-851.
20. Sakakura, H., Suzuki, M., Kimura, N., Takeda, H., Nagata, S., and Maeda, M. (1993) Simultaneous Determination of Bile Acids in Rat Bile and Serum by High Performance Liquid Chromatography, J. Chromatogr. 621, 123-131.
21. Sacquet, E.C., Gadelle, D.P., Riottot, M.J., and Raibaud, P.M. (1984) Absence of Transformation of β-Muricholic Acid by Human Microflora Implanted in the Digestive Tracts of Germfree Male Rats, Appl. Environ. Microbiol. 47, 1167-1168.