Fine mapping of an apparently targeted latent human herpesvirus type 6 integration site in chromosome band 17p13.3

Journal of Medical Virology

Volumn 58, Issue 1, 1999, Pages 69-75

  Morris, Christine ^a   Luppi, Mario ^b   McDonald, Margaret ^a   Barozzi, Patrizia ^b   Torelli, Giuseppe ^b,c  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Chromosome band 17p13.3; FISH; HHV 6; Lymphoproliferative; Nonrandom integration site; Telomere

Indexed keywords

ARTICLE; B CELL LYMPHOMA; CHROMOSOME 17P; CHROMOSOME ANALYSIS; CHROMOSOME BAND; CHROMOSOME MAP; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; KARYOTYPE; LATENT VIRUS INFECTION; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; ONCOGENE; TELOMERE; VIRUS DNA CELL DNA INTERACTION;

BINDING SITES; CHROMOSOME BANDING; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 17; GENOME, VIRAL; GTPASE-ACTIVATING PROTEINS; HERPESVIRUS 6, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERPHASE; KARYOTYPING; ONCOGENE PROTEIN V-CRK; PROTEINS; RETROVIRIDAE PROTEINS, ONCOGENIC; VIRUS INTEGRATION; VIRUS LATENCY;

DNA VIRUSES; HERPESVIRIDAE; HUMAN HERPESVIRUS 6;

EID: 0032947168     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199905)58:1<69::AID-JMV11>3.0.CO;2-3     Document Type: Article

References (64)

1. Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, Rose TM, Schultz ER, Bennett JL, Garber RL, Chang M, et al. 1995. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA 92:7440-7444.
2. Chattopadhyay P, Rathore A, Mathur M, Sarkar C, Mahapatra AK, Sinha S. 1997. Loss of heterozygosity of a locus on 17p13.3, independent of p53, is associated with higher grades of astrocytic tumours. Oncogene 15:871-874.
3. Chen M, Wang H, Woodworth CD, Lusso P, Berneman Z, Kingma D, Delgado G, DiPaolo JA. 1994. Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma. Am J Pathol 145:1509-1516.
4. Clark DA, Ait-Khaled M, Wheeler AC, Kidd IM, McLaughlin JE, Johnson MA, Griffiths PD, Emery VC. 1996. Quantification of human herpesvirus 6 in immunocompetent persons and post-mortem tissues from AIDS patients by PCR. J Gen Virol 77:2271-2275.
5. Crossen PE, Tully SM, Benjes SM, Hollings PE, Beard ME, Nimmo JC, Morrison MJ. 1993. Oligoclonal B-cell leukemia characterized by spontaneous cell division and telomere association. Genes Chromosomes Cancer 8:49-59.
6. Daibata M, Taguchi T, Kamioka M, Kubonishi I, Taguchi H, Miyoshi I. 1998a. Identification of integrated human herpesvirus 6 DNA in early pre-B cell acute lymphoblastic leukemia [letter]. Leukemia 12:1002-1004.
7. Daibata M, Taguchi T, Sawada T, Taguchi H, Miyoshi I. 1998b. Chromosomal transmission of human herpesvirus 6 DNA in acute lymphoblastic leukaemia. Lancet 352:543-544.
8. Dewhurst S, McIntyre K, Schnabel K, Hall CB. 1993. Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J Clin Microbiol 31:416-418.
9. Downing RG, Sewankambo N, Serwadda D, Honess R, Crawford D, Jarrett R, Griffin BE. 1987. Isolation of human lymphotropic herpesviruses from Uganda [letter]. Lancet 2:390.
10. Fitzgerald PH, Morris CM. 1984. Telomeric association of chromosomes in B-cell lymphoid leukemia. Hum Genet 67:385-390.
11. Compels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, Martin ME, Efstathiou S, Craxton M, Macaulay HA. 1995. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209:29-51.
12. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG. 1994. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 331:432-438.
13. Howell RT, Kitchen C, Standen GR. 1993. Telomeric associations in a patient with B-cell prolymphocytic leukaemia. Genes Chromosomes Cancer 7:116-118.
14. Irving WL, Cunningham AL. 1990. Serological diagnosis of infection with human herpesvirus type 6. BMJ 300:156-159.
15. Jarrett RF, Clark DA, Josephs SF, Onions DE. 1990. Detection of human herpesvirus-6 DNA in peripheral blood and saliva. J Med Virol 32:73-76.
16. Jarrett RF, Gledhill S, Qureshi F, Crae SH, Madhok R, Brown I, Evans I, Krajewski A, O'Brien CJ, Cartwright RA, et al. 1988. Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodgkin's lymphoma. Leukemia 2:496-502.
17. Josephs SF, Buchbinder A, Streicher HZ, Ablashi DV, Salahuddin SZ, Guo HG, Wong-Staal F, Cossman J, Raffeld M, Sundeen J, et al. 1988. Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients. Leukemia 2:132-135.
18. Jox A, Rohen C, Belge G, Bartnitzke S, Pawlita M, Diehl V, Bullerdiek J, Wolf J. 1997. Integration of Epstein-Barr virus in Burkitt's lymphoma cells leads to a region of enhanced chromosome instability. Ann Oncol 8:131-135.
19. Kao C, Wu SQ, DeVries S, Reznikoff WS, Waldman FM, Reznikoff CA. 1993. Carcinogen-induced amplification of SV40 DNA inserted at 9q12-21.1 associated with chromosome breakage, deletions, and translocations in human uroepithelial cell transformation in vitro. Genes Chromosomes Cancer 8:155-166.
20. Kashanchi F, Araujo J, Doniger J, Muralidhar S, Hoch R, Khleif S, Mendelson E, Thompson J, Azumi N, Brady JN, Luppi M, Torelli G, Rosenthal LJ. 1997. Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene 14:359-367.
21. Kersemaekers AM, Hermans J, Fleuren GJ, van de Vijver, MJ. 1998. Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix. Br J Cancer 77:192-200.
22. Kishi M, Harada H, Takahashi M, Tanaka A, Hayashi M, Nonoyama M, Josephs SF, Buchbinder A, Schachter F, Ablashi DV, et al. 1988. A repeat sequence, GGGTTA, is shared by DNA of human herpesvirus 6 and Marek's disease virus. J Virol 62:4824-4827.
23. Levy JA. 1997. Three new human herpesviruses (HHV6, 7, and 8). Lancet 349:558-563.
24. Levy JA, Ferro F, Greenspan D, Lennette ET. 1990. Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet 335:1047-1050.
25. Livezey KW, Simon D. 1997. Accumulation of genetic alterations in a human hepatoma cell line transfected with hepatitis B virus. Mutat Res 377:187-198.
26. Lopez C, Pellett P, Stewart J, Goldsmith C, Sanderlin K, Black J, Warfield D, Feorino P. 1988. Characteristics of human herpesvirus-6. J Infect Dis 157:1271-1273.
27. Lopez-Borges S, Gallego MI, Lazo PA. 1998. Recurrent integration of papillomavirus DNA within the human 12q14-15 uterine breakpoint region in genital carcinomas. Genes Chromosomes Cancer 23:55-60.
28. Luppi M, Barozzi P, Maiorana A, Marasca R, Trovato R, Fano R, Ceccherini-Nelli L, Torelli G. 1995. Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors. J Med Virol 47:105-111.
29. Luppi M, Barozzi P, Marasca R, Ceccherini-Nelli L, Torelli G. 1993a. Characterization of human herpesvirus 6 genomes from cases of latent infection in human lymphomas and immune disorders [letter]. J Infect Dis 168:1074-1075.
30. Luppi M, Marasca R, Barozzi P, Ferrari S, Ceccherini-Nelli L, Batoni G, Merelli E, Torelli G. 1993b. Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 40:44-52.
31. Lusso P, Markham PD, Tschachler E, di Marzo Veronese F, Salahuddin SZ, Ablashi DV, Pahwa S, Krohn K, Gallo RC. 1988. In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J Exp Med 167:1659-1670.
32. Martens UM, Zijlmans JM, Poon SS, Dragowska W, Yui J, Chavez EA, Ward RK, Lansdorp PM. 1998. Short telomeres on human chromosome 17p. Nat Genet 18:76-80.
33. McDonald JD, Daneshvar L, Willert JR, Matsumura K, Waldman F, Cogen PH. 1994. Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma. Genomics 23:229-232.
34. Mitelman F. 1995. An international system for human cytogenetic nomenclature. Basel: Karger.
35. Morris C, Benjes S, Haataja L, Ledbetter DH, Heisterkamp N, Groffen J. 1995. Spatial organization of ABR and CRK genes on human chromosome band 17p13.3. Oncogene 10:1009-1011.
36. Okuno T, Takahashi K, Balachandra K, Shiraki K, Yamanishi K, Takahashi M, Baba K. 1989. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol 27:651-653.
37. Phillips NJ, Ziegler MR, Radford DM, Fair KL, Steinbrueck T, Xynos FP, Donis-Keller H. 1996. Allelic deletion on chromosome 17p13.3 in early ovarian cancer. Cancer Res 56:606-611.
38. Pietroboni GR, Harnett GB, Bucens MR, Honess RW. 1988. Isolation of human herpesvirus 6 from saliva [letter] [published erratum appears in Lancet 1988 May 28;1(8596):1235]. Lancet 1:1059.
39. Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE, Schnabel KC, Pincus PH, Stamey FR, Dambaugh TR, et al. 1992. Primary human herpesvirus 6 infection in young children [see comments]. N Engl J Medic 326:1445-1450.
40. Razzaque A. 1990. Oncogenic potential of human herpesvirus-6 DNA. Oncogene 5:1365-1370.
41. Rogler CE, Sherman M, Su CY, Shafritz DA, Summers J, Shows TB, Henderson A, Kew M. 1985. Deletion in chromosome lip associated with a hepatitis B integration site in hepatocellular carcinoma. Science 230:319-322.
42. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, et al. 1986. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596-601.
43. Saltman D, Ross FM, Fantes JA, Allshire R, Turner GE, Evans HJ. 1989. Telomeric associations in a lymphoblastoid cell line from a patient with B-cell follicular lymphoma. Cytogenet Cell Genet 50: 230-233.
44. Sandros J, Stenman G. 1990. Karyotypic instability and viral integration in polyoma virus-induced mouse salivary gland tumors. Genes Chromosomes Cancer 2:109-115.
45. Sawyer JR, Miller JP, Ellison DA. 1998. Clonal telomeric fusions and chromosome instability in a subcutaneous sacrococcygeal myxopapillary ependymoma. Cancer Genet Cytogenet 100:169-175.
46. Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N. 1991. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci USA 88: 5922-5926.
47. Senger G, Ragoussis J, Trowsdale J, Sheer D. 1993. Fine mapping of the human MHC class II region within chromosome band 6p21 and evaluation of probe ordering using interphase fluorescence in situ hybridization. Cytogenet Cell Genet 64:49-53.
48. Shippey CA, Layton M, Secker-Walker LM. 1990. Leukemia characterized by multiple sub-clones with unbalanced translocations involving different telomeric segments: case report and review of the literature. Genes Chromosomes Cancer 2:14-17.
49. Singh N, Carrigan DR. 1996. Human herpesvirus-6 in transplantation: an emerging pathogen. Ann Intern Med 124:1065-1071.
50. Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S. 1997. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA [see comments]. Nat Med 3:1394-1397.
51. Sreekantaiah C, Karakousis CP, Leong SP, Sandberg AA. 1992. Cytogenetic findings in liposarcoma correlate with histopathologic subtypes. Cancer 69:2484-2495.
52. Stack M, Jones D, White G, Liscia DS, Venesio T, Casey G, Crichton D, Varley J, Mitchell E, Heighway J, et al. 1995. Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. Hum Mol Genet 4:2047-2055.
53. Steeper TA, Horwitz CA, Ablashi DV, Salahuddin SZ, Saxinger C, Saltzman R, Schwartz B. 1990. The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (HHV-6) in patients with mononucleosis-like illnesses not resulting from Epstein-Barr virus or cytomegalovirus. Am J Clin Pathol 93:776-783.
54. Takahashi K, Sonoda S, Higashi K, Kondo T, Takahashi H, Takahashi M, Yamanishi K. 1989. Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J Virol 63:3161-3163.
55. Tarkkanen M, Kaipainen A, Karaharju E, Bohling T, Szymanska J, Helio H, Kivioja A, Elomaa I, Knuutila S. 1993. Cytogenetic study of 249 consecutive patients examined for a bone tumor. Cancer Genet Cytogenet 68:1-21.
56. Temperani P, Giacobbi F, Gandini G, Torelli U, Emilia G. 1995. Chromosome rearrangements at telomeric level in hematologic disorders. Cancer Genet Cytogenet 83:121-126.
57. Thomson BJ, Dewhurst S, Gray D. 1994. Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini. J Virol 68:3007-3014.
58. Torelli G, Barozzi P, Marasca R, Cocconcelli P, Merelli E, Ceccherini-Nelli L, Ferrari S, Luppi M. 1995. Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivo. J Med Virol 46:178-188.
59. Trask B, Pinkel D, van den Engh G. 1989. The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs. Genomics 5:710-717.
60. Trask BJ, Massa H, Kenwrick S, Gitschier J. 1991. Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei. Am J Hum Genet 48:1-15.
61. van der Drift P, Chan A, van Roy N, Laureys G, Westerveld A, Speleman F, Versteeg R. 1994. A multimegabase cluster of snRNA and tRNA genes on chromosome 1p36 harbours an adenovirus/SV40 hybrid virus integration site. Hum Mol Genet 3:2131-2136.
62. Wan TS, Chan LC, Ngan HY, Tsao SW. 1997. High frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma viral oncogenes. Cancer Genet Cytogenet 95:166-172.
63. Wilke CM, Hall BK, Hoge A, Paradee W, Smith DI, Glover TW. 1996. FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. Hum Mol Genet 5:187-195.
64. Yamanishi K, Okuno T, Shiraki T, Takahashi M, Kondo T, Asano Y, Kurata T. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i:1065-1067.