Effect of colloidal silicon dioxide on flowing and tableting properties of an experimental, crosslinked polyalkylammonium polymer

Pharmaceutical Development and Technology

Volumn 4, Issue 2, 1999, Pages 285-289

  Chang, Rong Kun ^a,b   Leonzio, Michael ^a   Hussain, Munir A ^a  

^a DUPONT COMPANY   (United States)

^b Shire Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DMP 504; GLIDING AGENT; MAGNESIUM STEARATE; SILICON DIOXIDE;

ARTICLE; CONTROLLED STUDY; DENSITY; FLOW; FORCE; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION; TABLET HARDNESS; TABLET THICKNESS; WEIGHT;

EID: 0032946975     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101363     Document Type: Article

References (10)

1. Von E. Nurnberg, Experimentelle Prufungen von Direkt verprebten tablettengrundlagen, Pharm. Ind., 34(3), 193-206 (1972).
2. C. F. Lerk, G. K. Bolhuis, and S. S. Smedema, Interaction of lubricants and colloidal silica during mixing with excipients, Pharm. Acta. Helv., 52(3), 33-39 (1977).
3. P. Van Aerde, P. Pimhataivoot, R. Synave, and R. Van Severen, Direct compression of piracetam, Drug Dev. Ind. Pharm., 13(2), 225-234 (1987)
4. Z. T. Chowhan and I. C. Yang, Powder flow studies IV. Tensile strength and flow rate relationships of binary mixture, Int. J. Pharm., 14(4), 231-242 (1983).
5. J. Tasic, Z. Djuric, and M. Jovanovic, The influence of compression force on the physical characteristics of paracetamol tablets, Pharmazie, 46(3), 226-227 (1991).
6. G. C. Lubner and G. Ricciardiello, Influence of flow promoting agents on the flow properties of mixtures of powders and on the physical properties of the resulting tablets, Boll. Chim. Farm., 116(1), 20-52 (1977).
7. K. S. Raghavan, R. K. Chang, J. Pang, G. D. Figuly, and M. A. Hussain, Physical and chemical properties of DMP 504, a polyalkylammonium-based bile acid sequestrant, Pharm. Dev. Technol., 2(3), 233-241 (1997).
8. R.-K. Chang and M. A. Hussain, unpublished data.
9. D. Khossravi and W. T. Morehead, Consolidation mechanisms of pharmaceutical solids: a multi-compression cycle approach, Pharm. Res., 14(8), 1039-1045 (1997).
10. H. Vromans and C. F. Lerk, Densification properties and compactibility of mixtures of pharmaceutical excipients with and without magnesium stearate, Int. J. Pharm., 46, 183-192 (1988).