Structure-activity studies of normal and retro pig cecropin-melittin hybrids

Journal of Peptide Research

Volumn 53, Issue 3, 1999, Pages 244-251

  Juvvadi, P ^a   Vunnam, S ^a   Yoo, B ^a   Merrifield, Robert Bruce ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Antimicrobial peptides; Helix dipole; Ion channels; Retro peptides; Solid phase peptide synthesis

Indexed keywords

CECROPIN; CP(1-10)M(2-9) AMIDE; CP(1-9)M(1-8) AMIDE DERIVATIVE; CP(1-9)M(2-8) AMIDE DERIVATIVE; MELITTIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCHEMISTRY; ERYTHROCYTES; MELITTEN; MODELS, CHEMICAL; PEPTIDE BIOSYNTHESIS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0032946965     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.1999.00020.x     Document Type: Article

References (42)

1. 1. Hultmark, D., Steiner, H., Rasmuson, T. & Boman, H.G. (1980) Eur. J. Biochem. 106, 7-16.
2. 2. Lee, J.Y., Boman, A., Sun, C.X., Andersson, M., Jornvall, H., Mutt, V. & Boman, H.G. (1989) Proc. Natl Acad. Sci. USA. 86, 9159-9162.
3. 3. Andreu, D., Merrifield, R.B., Steiner, H. & Boman, H.G. (1983) Proc. Natl Acad. Sci. USA. 80, 6475-6479.
4. 4. Terwilliger, T.C. & Eisenberg, D. (1981) J. Biol. Chem. 257, 6016-6022.
5. 5. Boman, H.G. (1982) Fortchr. Zool. 27, 211-222.
6. 6. Habermann, E. (1972) Science. 177, 314-322.
7. 7. Habermann, E. & Jentsch, J. (1967) Hoppe-Seylers Z. Physiol. Chem. 348, 37-50.
8. 8. Boman, H.G. (1995) Annu. Rev. Immunol. 13, 61-92.
9. 9. Andreu, D., Aschauer, H., Kreil, G. & Merrifield, R.B. (1985) Eur. J. Biochem. 149, 531-535.
10. 10. Zasloff, M. (1987) Proc. Natl Acad. Sci. USA 84, 5449-5453.
11. 11. Eisenhauer, P.B., Harwig, S.S.S.L. & Lehrer, R.I. (1992) Infect. Immun. 60, 3556-3565.
12. 12. Lehrer, R.I., Lichenstein, A.K. & Gang, T. (1993) Ann. Rev. Immunol. 11, 105-128.
13. 13. Frank, R.W., Gennaro, R., Schneider, K., Przybylski, M. & Romeo, D. (1990) J. Biol. Chem. 165, 18871-18874.
14. 14. Agerberth, B., Lee, J.-Y., Bergman, T., Carlquist, M., Boman, H.G., Mutt, V. & Jornvall, H. (1991] Eur. J. Biochem. 101, 849-854.
15. 15. Shi, J., Ross, C.R., Chengappa, M.M. & Blecha, F. (1994) J. Leuk. Biol. 56, 807-811.
16. 16. Boman, H.G., Wade, D., Boman, I.A., Wahlin, B. & Merrifield, R.B. (1989) FEBS Lett. 259, 103-106.
17. 17. Andreu, D., Ubach, J., Boman, A., Wahlin, B., Wade, D., Merrifield, R.B. & Boman, H.G. (1992) FEBS Lett. 296, 190-194.
18. 18. Wade, D., Andreu, D., Mitchell, S.A., Silveira, A.M.V., Boman, A., Boman, H.G. & Merrifield, R.B. (1992) Int. J. Peptide Protein Res. 40, 429-436.
19. 19. Wade, D., Boman, A., Wahlin, B., Drain, C.M., Andreu, D., Boman, H.G. & Merrifield, R.B. (1990) Proc. Natl Acad. Sci. USA 87, 4761-4765.
20. 20. Merrifield, E.L., Mitchell, S.A., Uhach, J., Boman, H.G., Andreu, D. & Merrifield, R.B. (1995) Int. J. Peptide Protein Res. 46, 214-220.
21. 21. Christensen, B., Fink, J., Merrifield, R.B. & Mauzerall, D. (1988) Proc. Natl Acad. Sci. USA 85, 5073-5076.
22. 22. Juvvadi, P., Vunnam, S. & Merrifield, R.B. (1996) J. Am. Chem. Soc. 118, 8989-8997.
23. 23. Cruciani, R.A., Barker, J.L., Zasloff, M., Chen, H.C. & Colamonici, O. (1991) Proc. Natl Acad. Sci. USA 88, 3792-3796.
24. 24. Kagan, B.L., Selsted, M.E., Ganz, T. & Lehrer, R.I. (1990) Proc. Natl Acad. Sci. USA 87, 110-214.
25. 25. Gazit, E., Boman, A., Boman, H.G. & Shai, Y. (1995) Biochemistry 34, 11479-11488.
26. 26. Merrifield, R.B. (1963) J. Am. Chem. Soc. 85, 2149-2154.
27. 27. Matseuda, G.R. & Stewart, J.M. (1981) Peptides 2, 45-50.
28. 28. Sarin, V.K., Kent, S.B.H., Tam, J.P. & Merrifield, R.B. (1981) Anal. Biochem. 117, 147-157.
29. 29. Tam, J.P., Heath, W.F. & Merrifield, R.B. (1983) J. Am. Chem. Soc. 105, 6442-6455.
30. 30. Westall, F.C., Scotchler, J. & Robinson, A.B. (1972) J. Org. Chem. 37, 3363-3365.
31. 31. Chowdhury, S.K., Katta, V. & Chait, B.T. (1990) Rapid Commun. Mass Spectrometry 4, 81-87.
32. 32. Hultmark, D., Engstrom, A., Bennich, H., Kapur, R. & Boman, H.G. (1982) Eur. J. Biochem. 127, 207-217.
33. 33. Hultmark, D., Engstrom, A., Andersson, K., Steiner, H., Bennich, H. & Boman, H.G. (1983) EMBO J.2, 571-576.
34. 34. Chen, Y.-H., Yang, J.T. & Chau, K.H. (1974) Biochemistry 13, 3350-3359.
35. 35. Drain, C.M., Christensen, B. & Mauzerall, D. (1989) Proc. Natl Acad. Sci. USA 86, 6959-6962.
36. 36. Mueller, P., Rudin, D.O., Tien, H.T. & Wescott, W.C. (1963) J. Phy. Chem. 67, 534-535.
37. 37. Montal, M. & Mueller, P. (1972) Proc. Natl Acad Sci. USA 69, 3561-3566.
38. 38. Merrifield, R.B., Juvvadi, P., Andreu, D., Ubach, J., Boman, A. & Boman, H.G. (1995) Proc. Natl Acad. Sci. USA 92, 3449-3453.
39. 39. Meek, J.L. (1980) Proc. Natl Acad. Sci. USA 77, 1632.
40. 40. Sasagawa, T., Okuyama, T. & Teller, D.C. (1982) J. Chromatogr. 240, 329.
41. 41. Shoemaker, K.R., Kim, P.S., York, E.J., Stewart, J.M. & Baldwin, R.L. (1987) Nature 326, 563-567.
42. 42. Fernandez, I., Ubach, J., Reig, F., Andreu, D. & Pons, M. (1994) Biopolymers 34, 1251-1258.