Chemical modification of the mitochondrial permeability transition pore by specific amino acid reagents

Drug Development Research

Volumn 46, Issue 1, 1999, Pages 14-17

  Bernardi, Paolo ^a   Colonna, Raffaele ^a   Costantini, Paola ^a,b   Eriksson, Ove ^a,c   Nicolli, Annamaria ^a,d   Petronilli, Valeria ^a   Scorrano, Luca ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b CNRS   (France)

^c UNIVERSITY OF HELSINKI   (Finland)

^d Istituto di Medicina Clinica Padova   (Italy)

Author keywords

Apoptosis; Cell death; Channels; Cyclosporin; Mitochondria

Indexed keywords

1,10 PHENANTHROLINE COPPER; 2,3 BUTANEDIONE; ARGININE; ARSENIC TRIOXIDE; ARSENOSOBENZENE; BROMOBIMANE; CYCLOPHILIN; CYCLOSPORIN A; DIAMIDE; DITHIOTHREITOL; MERCAPTOETHANOL; N ETHYLMALEIMIDE; PHENYLGLYOXAL; PYRIDINE NUCLEOTIDE; TERT BUTYL HYDROPEROXIDE;

APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CONCENTRATION RESPONSE; MEMBRANE CHANNEL; MOLECULAR DYNAMICS; OXIDATION REDUCTION REACTION; PH; PROTEIN MODIFICATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0032946703     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199901)46:1<14::AID-DDR3>3.0.CO;2-L     Document Type: Article

References (29)

1. Bernardi P. 1992. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient: evidence that the pore can be opened by membrane depolarization. J Biol Chem 267:8834-8839.
2. Bernardi P, Basso E, Colonna R, Costantini P, Di Lisa F, Eriksson O, Fontaine E, Forte M, Ichas F, Massari S, Nicolli A, Petronilli V, Scorrano I. 1998. Perspectives on the mitochondrial permeability transition. Biochim Biophys Acta 1365:200-206.
3. Bernardi P, Petronilli V. 1996. The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal. J Bioenerg Biomembr 28:131-138.
4. Bernardi P, Vassanelli S, Veronese P, Colonna R, Szabo I, Zoratti M. 1992. Modulation of the mitochondrial permeability transition pore: effect of protons and divalent cations. J Biol Chem 267:2934-2939.
5. Chernyak BV, Bernardi P. 1996. The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites. Eur J Biochem 238:623-630.
6. Connern CP, Halestrap AP. 1996. Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]. Biochemistry 35:8172-8180.
7. Costantini P, Chernyak BV, Petronilli V, Bernardi P. 1995. Selective inhibition of the mitochondrial permeability transition pore at the oxidation-reduction sensitive dithiol by monobromobimane. FEBS Lett 362:239-242.
8. Costantini P, Chernyak BV, Petronilli V, Bernardi P. 1996. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J Biol Chem 271:6746-6751.
9. Costantini P, Colonna R, Bernardi P. 1998. Induction of the mitochondrial permeability transition pore by N-ethylmaleimide depends on secondary oxidation of critical thiol groups: potentiation by copper-ortho-phenanthroline without dimerization of the adenine nucleotide translocase. Biochim Biophys Acta 1365:385-392.
10. Eriksson O, Fontaine E, Bernardi P. 1998. Chemical modification of arginines by 2,3-butanedione and phenylglyoxal causes closure of the mitochondrial permeability transition pore. J Biol Chem 273:12669-12674.
11. Eriksson O, Fontaine E, Petronilli V, Bernardi P. 1997. Inhibition of the mitochondrial cyclosporin A-sensitive permeability transition pore by the arginine reagent phenylglyoxal. FEBS Lett 409:361-364.
12. Farber JL. 1990. The role of calcium in lethal cell injury. Chem Res Toxicol 3:503-508.
13. Gunter KK, Gunter TE. 1994. Transport of calcium by mitochondria. J Bioenerg Biomembr 26:471-485.
14. Gunter TE, Pfeiffer DR. 1990. Mechanisms by which mitochondria transport calcium. Am J Physiol 258:C755-C786.
15. Hunter DR, Haworth RA. 1979a. The Ca2+-induced membrane transition in mitochondria: I. The protective mechanisms. Arch Biochem Biophys 195:453-459.
16. Hunter DR, Haworth RA. 1979b. The Ca2+-induced membrane transition in mitochondria: III. Transitional Ca2+ release. Arch Biochem Biophys 195:468-477.
17. Ichas F, Jouaville LS, Mazat JP. 1997. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89:1145-1153.
18. Kroemer G. 1997. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3:614-620.
19. Mancini M, Nicholson DW, Roy S, Thomberry NA, Peterson EP, Casciola RL, Rosen A. 1998. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol 140:1485-1495.
20. Marchetti P, Decaudin D, Macho A, Zamzami N, Hirsch T, Susin SA, Kroemer G. 1997. Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function. Eur J Immunol 27:289-296.
21. Nicolli A, Basso E, Petronilli V, Wenger RM, Bernardi P. 1996. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel. J Biol Chem 271:2185-2192.
22. Nicolli A, Petronilli V, Bernardi P. 1993. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH: evidence that the pore open-closed probability is regulated by reversible histidine protonation. Biochemistry 32:4461-4465.
23. Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL. 1998. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 273:7770-7775.
24. Petronilli V, Cola C, Massari S, Colonna R, Bernardi P. 1993. Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria. J Biol Chem 268:21939-21945.
25. Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P. 1994. Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A. Biochim Biophys Acta 1187:255-259.
26. Salet C, Moreno G, Ricchelli F, Bernardi P. 1997. Singlet oxygen produced by photodynamic action causes inactivation of the mitochondrial permeability transition pore. J Biol Chem 272:21938-21943.
27. Scorrano L, Nicolli A, Basso E, Petronilli V, Bernardi P. 1997. Two modes of activation of the permeability transition pore: the role of mitochondrial cyclophilin. Mol Cell Biochem 174:181-184.
28. Susin SA, Zamzami N, Castedo M, Hirsch T, Marchetti P, Macho A, Daugas E, Geuskens M, Kroemer G. 1996. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184:1331-1341.
29. Zoratti M, Szabo I. 1995. The mitochondrial permeability transition. Biochim Biophys Acta 1241:139-176.