Expression of tumor necrosis factor-α gene during allograft rejection following rat liver transplantation

Liver

Volumn 19, Issue 1, 1999, Pages 19-24

  Teramoto, Kenichi ^a   Tanaka, Yujiro ^b   Kusano, Fumihiko ^b   Hara, Yuzuru ^b   Ishidate, Kozo ^b   Iwai, Takehisa ^b   Sato, Chifumi ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NONE

Author keywords

Allograft rejection; Apoptosis; In situ hybridization; Liver transplantaton; Rat; Tumor necrosis factor alpha

Indexed keywords

DNA FRAGMENT; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KUPFFER CELL; LIVER CELL; LIVER SINUSOID; LIVER TRANSPLANTATION; MACROPHAGE; MALE; MONOCYTE; MONONUCLEAR CELL; NONHUMAN; RAT;

ANIMALS; GENE EXPRESSION; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; KUPFFER CELLS; LIVER; LIVER TRANSPLANTATION; RATS; RATS, INBRED ACI; RATS, INBRED LEW; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032945362     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.1999.tb00004.x     Document Type: Article

References (18)

1. IMAGAWA D K, MILLIS J M, OLTHOFF K M, et al. The role of tumor necrosis factor in allograft rejection. I. Evidence that elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation. Transplantation 1990; 50: 219-25.
2. IMAGAWA, D K, MILLIS J M, SEU P, et al. The role of tumor necrosis factor in allograft rejection. III. Evidence that anti-TNF antibody therapy prolongs allograft survival in rats with acute rejection. Transplantation 1991; 51: 57-62.
3. TERAMOTO, K, BAQUERIZO A, IMAGAWA D K, et al. Prolongation of hepatic allograft survival in rat recipients treated with anti-lymphotoxin antibody. Transplantation Proc 1991
4. GRUNFELD C, PALLADINO M A. Tumor necrosis factor: Immunologic, antitumor, metabolic, and cardiovascular activities. In: Siperstein M, ed. Advances in Internal Medicine, Chicago IL: Year Book Medical, 1990: 45.
5. KRAMS S M, EGAWA H, QUINN M B, VILLANUEVA J C, GARCIA-KENNEDY R, MARTINEZ O M. Apoptosis as a mechanism of cell death in liver allograft rejection. Transplantation 1995; 59: 621-5.
6. SHINAGAWA T, YOSHIOKA K, KAKUMU S, et al. Apoptosis in cultured rat hepatocytes: the effects of tumour necrosis factor alpha and interferon gamma. J Pathol 1991; 165: 247-53.
7. SELMAJ K. RAINE C S, FAROOQ M, NORTON W T, BROSNAN C F. Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol 1991; 147: 1522-9.
8. TAKEI Y, KAWANO S, NISHIMURA Y, et al. Apoptosis: a new mechanism of endothelial and Kupffer cell killing. J Gastroenterol Hepatol 1995; 10: 65-7.
9. HIGUCHI M, SINGH S, AGGARWAL B B. Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells. J Immunol Methods 1995; 178: 173-81.
10. KAMADA N. Experimental liver transplantation. 1988: New York, USA: CRC press. 7-12.
11. DIJKSTRA C D, DOPP E A, JOLING P, KRAAL G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985; 54: 589-99.
12. MISUMI M, YAMAGUCHI Y, MORI K. et al. In situ macrophage distribution in the hepatic allograft associated with rejection in the rat. J Surg Res 1993; 55: 115-21.
13. GAVRIELI Y, SHERMAN Y, BEN SASSON SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
14. GOTO M, TAKEI Y, KAWANO S, et al. Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injuries after orthotopic liver transplantation in the rat. Hepatology 1992; 16: 487-93.
15. COLLETTI L M, BURTCH G D, REMICK D G, et al. The production of tumor necrosis factor alpha and the development of a pulmonary capillary injury following hepatic ischemia/reperfusion. Transplantation 1990; 49: 268-72.
16. DECKER T, LOHMANN-MATTHES M L, GIFFORD G. Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages. J Immunol 1987; 138: 957-62.
17. MARTINEZ O M, KRAMS S M, STERNECK M, et al. Intragraft cytokine profile during human liver allograft rejection. Transplantation: 1992; 53: 449-56.
18. LASTER S M, WOOD J G, GOODING L R. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol 1988; 141: 2629-34.