New minimal substrate structural requirements in the enzymatic peroxidation of alkenes with soybean lipoxygenase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 1, 1999, Pages 31-34

  Novak, Mark J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; CARBOXYL GROUP; FATTY ACID DERIVATIVE; LIPOXYGENASE;

ARTICLE; CATALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; LIPID PEROXIDATION;

ACETIC ACIDS; ALKENES; LIPOXYGENASE; OXIDATION-REDUCTION; PEROXIDES; SOYBEANS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

GLYCINE MAX;

EID: 0032945028     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00680-5     Document Type: Article

References (11)

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3. (a) Brash, A. R.; Ingram, C. D.; Harris, T. M. Biochemistry 1987, 26, 5465.
4. (b) Eskola, J.; Laasko, S. Biochim. Biophys. Acta 1983, 751, 305.
5. Datcheva, V. K.; Kiss, K.; Solomon, L.; Kyler, K. S. J. Am. Chem. Soc. 1991, 113, 270.
6. Lipoxygenase 1 (Type I, from soybeans) was obtained from Sigma Co. and used without further purification. The enzyme activity was determined by the standard assay procedure: Axelrod, B.; Cheesbrough, T. M.; Laasko, S. Methods Enzymol. 1981, 71, 441.
7. A modification of Funk was used: Andre, J. C.; Funk, M. O. Jr. Anal. Biochem. 1989, 158, 316.
8. Rekker, R. F. The Hydrophobic Fragmental Constant; Elsevier: Amsterdam 1977.
9. All compounds gave satisfactory analytical analyses.
10. Praley, J. P.; Lemieux, R. U. Can. J. Chem. 1987, 65, 213.
11. Carvalho, J. F.; Prestwich, G. D. J. Org. Chem. 1984, 49, 1251.