Hepatitis C virus core protein fused to hepatitis B virus core antigen for serological diagnosis of both hepatitis C and hepatitis B infections by ELISA

Journal of Medical Virology

Volumn 57, Issue 2, 1999, Pages 104-110

  Wu, Chao Liang ^a   Leu, Tzong Shiann ^a   Chang, Ting Tsung ^a   Shiau, Ai Li ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Diagnosis; HBV core antigen; HCV core; Hybrid HBcAg particle

Indexed keywords

VIRUS ANTIGEN;

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ANTIGENICITY; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; IMMUNOBLOTTING; VIRUS CORE;

ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; MALE; MICE; MICE, INBRED BALB C; RABBITS; RECOMBINANT FUSION PROTEINS; SEROLOGIC TESTS; TIME FACTORS; VIRAL CORE PROTEINS;

DNA VIRUSES; HEPATITIS B VIRUS; HEPATITIS C VIRUS; ORYCTOLAGUS CUNICULUS; RNA VIRUSES;

EID: 0032944906     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199902)57:2<104::AID-JMV3>3.0.CO;2-7     Document Type: Article

References (43)

1. Borisova G, Arya B, Dislers A, Borschukova O, Tsibinogin V, Skrastina D, Eldarov MA, Pumpens P, Skryabin KG, Grens E. 1993. Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen. J Virol 67: 3696-3701.
2. Böttcher B, Wynne SA, Crowther RA. 1997. Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386:88-91.
3. Burrell CJ, MacKay P, Greenaway PJ, Hofschneider PH, Murray K. 1979. Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322. Nature 279:43-47.
4. Chen PJ, Wang JT, Hwang LH, Yang YH, Hsieh CL, Kao JH, Sheu JC, Lai MY, Wang TH, Chen DS. 1992a. Transient immunoglobulin M antibody response to hepatitis C virus capsid antigen in posttransfusion hepatitis C: Putative serological marker for acute viral infection. Proc Nat Acad Sci USA 89:5971-5975.
5. Chen PJ, Lin MH, Tai KF, Liu PC, Lin CJ, Chen DS. 1992b. The Taiwanese hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA. Virology 188:102-113.
6. Chou WH, Sheu SH, Sheu L, Lu CF, Lin SY, Wu JS. 1993. Sequence analysis of nucleocapsid and partial envelope genes of the hepatitis C virus derived from an aboriginal asymptomatic carrier. Chinese J Microbiol Immunol 26:57-67.
7. Claeys H, Volckaerts A, Beenhouwer HD, Vermylen C. 1992. Association of hepatitis C virus carrier state with the occurrence of hepatitis C virus core antibodies. J Med Virol 36:259-264.
8. Clarke BE, Newton SE, Carroll AR, Francis MJ, Appleyard G, Syred AD, Highfield PE, Rowlands DJ, Brown F. 1987. Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein. Nature 330:381-384.
9. Cohen BJ, Richmond JE. 1982. Electron microscopy of hepatitis B core antigen synthesized in E. coli. Nature 296:677-679.
10. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC Jr, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, Van-Thiel DH, Tamburro C, Lefkowitch J, Albrecht J, Meschievitz C, Ortego TJ, Gibas A, The Hepatitis Interventional Group. 1989. Treatment of chronic hepatitis C with recombinant interferon alfa: A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group. N Engl J Med 321:1501-1506.
11. Dhaliwal SK, Prescott LE, Dow BC, Davidson F, Brown H, Yap PL, Follett EAC, Simmonds P. 1996. Influence of viraemia and geno-type upon serological reactivity in screening assays for antibody to hepatitis C virus. J Med Virol 48:184-190.
12. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Banks SM, Hoofnagle JH. 1989. Recombinant interferon alfa therapy for chronic hepatitis C: A randomized, double-blind, placebo-controlled trial. N Engl J Med 321: 1506-1510.
13. Handschuh G, Caselmann WH. 1995. Bacterial expression and purification of hepatitis virus capsid proteins of different size. J Hepatol 22:143-150.
14. Harada S, Watanabe Y, Takeuchi K, Suzuki T, Katayama T, Takebe Y, Saito I, Miyamura T. 1991. Expression of processed core protein of hepatitis C virus in mammalian cells. J Virol 65:3015-3021.
15. Khanna A, Ray R. 1995. Hepatitis C virus core protein: Synthesis, affinity purification and immunoreactivity with infected human sera. Gene 153:185-189.
16. Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, Walker BD. 1993. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol 67:7522-7532.
17. Kroll DJ, Abdel-Malek Abdel-Hafiz H, Marcell T, Simpson S, Chen CY, Gutierrez-Hartmann A, Lustbader JW, Hoeffler JP. 1993. A multifunctional prokaryotic protein expression system: Overproduction, affinity purification, and selective detection. DNA Cell Biol 12:441-453.
18. Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, Tegtmeier GE, Bonino F, Colombo M, Lee WS, Kuo C, Berger K, Shuster JR, Overby LR, Bradley DW, Houghton M. 1989. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362-364.
19. Milich DR, McLachlan A, Thornton GB, Hughes JL. 1987a. Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site. Nature 329:547-549.
20. Milich DR, McLachlan A, Moriarty A, Thornton GB. 1987b. A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg. J Immunol 138:4457-4465.
21. Milton ID, Watson JP, Guo K, Carter MJ, Bassendine MF, Toms GL. 1995. Prokaryotic expression and analysis of the antibody response to a Newcastle isolate of the core gene of hepatitis C. J Med Virol 45:253-258.
22. Motulsky H. 1995. Intuitive Biostatistics. New York: Oxford University Press.
23. Nakagiri I, Ichihara K. 1995. ELISA for anti-HCV antibody employing a shorter synthetic core region peptide. J Virol Methods 52: 195-207.
24. Nasoff MS, Zebedee SL, Inchauspe G, Prince AM. 1991. Identification of an immunodominant epitope within the capsid protein of hepatitis C virus. Proc Nat Acad Sci USA 88:5462-5466.
25. Neurath AR, Kent SB, Strick N. 1984. Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus. Science 224:392-395.
26. Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Y, Mayumi M. 1991. Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: Comparison with reported isolates for conserved and divergent regions. J Gen Virol 72:2697-2704.
27. Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y, Mayumi M. 1992. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources. J Gen Virol 73:673-679.
28. Pumpens P, Borisova GP, Crowther RA, Grens E. 1995. Hepatitis B virus core particles as epitope carriers. Intervirology 38:63-74.
29. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo QL, Houghton M, Kuo G. 1990. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Nat Acad Sci USA 87: 6547-6549.
30. Schodel F, Moriarty AM, Peterson DL, Zheng JA, Hughes JL, Will H, Leturcq DJ, McGee JS, Milich DR. 1992. The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity. J Virol 66:106-114.
31. Schodel F, Wirtz R, Peterson D, Hughes J, Warren R, Sadoff J, Milich D. 1994. Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes. J Exp Med 180:1037-1046.
32. Shiau AL. 1993. Immunological aspects of hepatitis B virus core antigen and its derivatives. PhD thesis. Edinburgh: University of Edinburgh.
33. Shiau AL, Murray K. 1997. Mutated epitopes of hepatitis B surface antigen fused to the core antigen of the virus induce antibodies that react with the native surface antigen. J Med Virol 51:159-166.
34. Shirai M, Okada H, Nishioka M, Akatsuka T, Wychowski C, Houghten R, Pendleton CD, Feinstone SM, Berzofsky JA. 1994. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans. J Virol 68:3334-3342.
35. Stahl S, MacKay P, Magazin M, Bruce SA, Murray K. 1982. Hepatitis B virus core antigen: Synthesis in Escherichia coli and application in diagnosis. Proc Nat Acad Sci USA 79:1606-1610.
36. Stahl SJ, Murray K. 1989. Immunogenicity of peptide fusions to hepatitis B virus core antigen. Proc Nat Acad Sci USA 86:6283-6287.
37. Takeuchi K, Boonmar S, Kubo Y, Katayama, T, Harada H, Ohbayashi A, Choo QL, Kuo G, Houghton M, Saito I, Miyamura T. 1990. Hepatitis C virus cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene 91:287-291.
38. Thornton GB, Moriarty AM, Milich DR, Eichberg JW, Purcell RH, Gerin JL. 1989. Protection of chimpanzees from hepatitis-B virus infection after immunization with synthetic peptides: Identification of protective epitopes in the pre-S region. In: Lerner RA, Ginsberg H, Chanock RM, Brown, F, editors. Vaccines 89: Modern approaches to new vaccines including prevention of AIDS. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, p 467-471.
39. Tindle RW, Herd K, Londono P, Fernando GJ, Chatfield SN, Malcolm K, Dougan G. 1994. Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice. Virology 200:547-557.
40. Trowbridge R, Sloots TP, Buda P, Faoagali J, Hyland C, Young I, Gowans EJ. 1996. An ELISA for the detection of antibody to the core antigen of hepatitis C virus: Use in diagnosis and analysis of indeterminate samples. J Hepatol 24:532-538.
41. c) expressed in Escherichia coli. J Immunol Methods 148:143-150.
42. Yoshikawa A, Tanaka T, Hoshi Y, Kato N, Tachibana K, Iizuka H, Machida A, Okamoto H, Yamasaki M, Miyakawa Y, Mayumi M. 1993. Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein. J Virol 67:6064-6070.
43. Young KC, Chang TT, Liou TC, Wu HL. 1993. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells and in saliva. J Med Virol 41:55-60.