Recombinant bactericidal/permeability-increasing protein (rBPI21) in combination with sulfadiazine is active against Toxoplasma gondii

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 4, 1999, Pages 758-762

  Khan, Anis A ^a,b   Lambert Jr , Lewis H ^c   Remington, Jack S ^a,b   Araujo, Fausto G ^a  

^a PALO ALTO MEDICAL FOUNDATION   (United States)

^b XOMA Corporation   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERICIDAL PERMEABILITY INCREASING PROTEIN; RECOMBINANT PROTEIN; SULFADIAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 0032944786     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.4.758     Document Type: Article

References (23)

1. Ammons, W. S., F. R. Kohn, and A. H. C. Kung. 1994. Protective effects of an N-terminal fragment of bactericidal/permeability-increasing protein in rodent models of gram-negative sepsis: role of bactericidal properties. J. Infect. Dis. 170:1473-1482.
2. Amura, C. R., L. C. Chen, N. Hirohashi, M. G. Lei, and D. C. Morrison. 1997. Two functionally independent pathways for lipopolysaccharide-dependent activation of mouse peritoneal macrophages. J. Immunol. 159:5079-5083.
3. Araujo, F. G., A. A. Khan, and J. S. Remington. 1996. Rifapentine is active in vitro and in vivo against Toxoplasma gondii. Antimicrob. Agents Chemother. 40:1335-1337.
4. Araujo, F. G., A. A. Khan, T. L. Slifer, A. Bryskier, and J. S. Remington. 1997. The ketolide antibiotics HMR 3647 and HMR 3004 are active against Toxoplasma gondii in vitro and in murine models of infection. Antimicrob. Agents Chemother. 41:2137-2140.
5. Araujo, F. G., and T. Slifer. 1995. Nonionic block copolymers potentiate activities of drugs for treatment of infections with Toxoplasma gondii. Antimicrob. Agents Chemother. 39:2696-2701.
6. Beaman, M. H., R. E. McCabe, S. Y. Wong, and J. S. Remington. 1995. Toxoplasma gondii, p. 2455-2475. In G. L. Mandell, R. G. Douglas, Jr., and J. E. Bennett (ed.), Principles and practice of infectious diseases, 4th ed., vol. 2. Churchill Livingstone, New York, N.Y.
7. Berenbaum, M. C. 1978. A method for testing synergy with any number of agents. J. Infect. Dis. 137:122-130.
8. Chou, T. C., and M. P. Hayball. 1996. CalcuSyn: a Windows software for dose-effect analysis. User's manual. Biosoft, Ferguson, Mo.
9. Chou, T. C., and P. Talalay. 1984. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 22:27-55.
10. Dentener, M. A., E. J. Von Asmuth, G. J. Francot, M. N. Marra, and W. A. Buurman. 1993. Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide. J. Immunol. 151:4258-4265.
11. Elsbach, P., and J. Weiss. 1995. Prospects for use of recombinant BPI in the treatment of gram-negative bacterial infections. Infect. Agents Dis. 4:102-109.
12. Gazzano-Santoro, H., J. B. Parent, L. Grinna, A. Horwitz, T. Parsons, G. Theofan, P. Elsbach, J. Weiss, and P. J. Conlon. 1992. High-affinity binding of the bactericidal/permeability increasing protein and a recombinant aminoterminal fragment to the lipid A region of lipopolysaccharide. Infect. Immun. 60:4754-4761.
13. Horwitz, A. H., S. D. Leigh, S. Abrahamson, H. Gazzano-Santoro, P.-S. Liu, R. E. Williams, S. F. Carroll, and G. Theofan. 1996. Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein. Protein Expr. Purif. 8:28-40.
14. Liesenfeld, O., S. Y. Wong, and J. S. Remington. 1998. Toxoplasmosis in the setting of AIDS, p. 225-259. In J. G. Bartlett, T. C. Merigan, and D. Bolognesi (ed.), Textbook of AIDS medicine, 2nd. ed. The Williams & Wilkins Co., Baltimore, Md.
15. Lin, Y., W. J. Leach, and W. S. Ammons. 1996. Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit gram-negative sepsis. Antimicrob. Agents Chemother. 40:65-69.
16. Mannion, B. A., J. Weiss, and P. Elsbach. 1990. Separation of sublethal and lethal effects of polymorphonuclear leukocytes on Escherichia coli. J. Clin. Invest. 86:631-641.
17. Marra, M. N., C. G. Wilde, M. S. Collins, J. L. Snable, M. B. Thornton, and R. W. Scott. 1992. The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxin. J. Immunol. 148:532-537.
18. Marra, M. N., C. G. Wilde, J. E. Griffith, J. L. Snable, and R. W. Scott. 1990. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. J. Immunol. 144:662-666.
19. 21) is more related to its anti-bacterial than anti-endotoxin properties in baboon sepsis, abstr 57. In Program and abstracts of the 6th Vienna Shock Forum. The European Shock Society, Vienna, Austria.
20. Von der Mohlen, M. A. M., A. N. Kimmings, N. I. Wedel, M. L. C. M. Mevissen, J. Jansen, N. Friedmann, T. J. Lorenz, B. J. Nelson, M. L. White, R. Bauer, C. E. Hack, A. J. M. Eerenberg, and S. J. H. Van Deventer. 1995. Inhibition of endotoxin-induced cytokine release and neutrophil activation in humans by use of recombinant/permeability-increasing protein. J. Infect. Dis. 172:144-151.
21. Weiss, J., P. Elsbach, I. Olsson, and O. Odeberg. 1978. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J. Biol. Chem. 253: 2664-2672.
22. Weiss, J., M. Victor, and P. Elsbach. 1983. Role of charge and hydrophobic interactions in the action of the bactericidal/permeability-increasing protein of neutrophils on gram-negative bacteria. J. Clin. Invest. 71:540-549.
23. Wiese, A., K. Brandenburg, S. F. Carroll, E. T. Rietschel, and U. Seydel. 1997. Mechanisms of action of bactericidal/permeability-increasing protein BPI on reconstituted outer membranes of gram-negative bacteria. Biochemistry 36:10311-10319.