Total synthesis of (±)-acetomycin and design of esterase-resistant analogs

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 4, 1999, Pages 517-523

  Uenishi, Jun'ichi ^a   Kobayashi, Naoko ^a   Komine, Shiho ^a   Okadai, Takeshi ^a   Yonemitsu, Osamu ^a   Sasaki, Takuma ^b   Yamada, Yuji ^c  

^a OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Acetomycin; Antibiotic; Cytotoxicity; Esterase; Stereoselective synthesis

Indexed keywords

ACETOMYCIN; ACETOMYCIN DERIVATIVE; ESTERASE; NATURAL PRODUCT; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; FURAN DERIVATIVE; GROWTH INHIBITOR;

ARTICLE; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; NONHUMAN; STRUCTURE ANALYSIS; ANIMAL; CELL STRAIN KB; DRUG STABILITY; HUMAN; IC 50; LEUKEMIA L 1210; METABOLISM; MOUSE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SWINE; SYNTHESIS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DRUG STABILITY; ESTERASES; FURANS; GROWTH INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KB CELLS; LEUKEMIA L1210; MICE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0032944486     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.517     Document Type: Article

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