Induction of antibodies to methadone during methadone maintenance treatment of heroin addicts and its possible clinical implications

European Journal of Pharmacology

Volumn 369, Issue 3, 1999, Pages 357-364

  Gamaleya, Natalia ^a   Dmitrieva, Irina ^a   Borg, Stefan ^b   Ericcson, Nadja ^b  

^a Research Inst for Addiction   (Russian Federation)

^b St Goran Clin of Dependence Disord   (Sweden)

Author keywords

Antibody; Blood plasma; Human; Immunodeficiency virus infection; Methadone

Indexed keywords

DRUG ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; METHADONE; MORPHINE;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEROIN DEPENDENCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; METHADONE TREATMENT; PRIORITY JOURNAL; TECHNIQUE;

EID: 0032943656     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00066-7     Document Type: Article

References (37)

1. Beck O., Boreus L.O., Borg S., Jacobsson G., Lafolie P., Stensio M. Monitoring of plasma methadone: intercorrelation between immunoassay and gas chromatography-mass spectrometry. Ther. Drug Monit. 12:1990;473-477.
2. Bell J., Seres B., Bowron P., Lewis J., Batey R. Serum levels of methadone in maintenance clients who persist in illicit drug use. Br. J. Addict. 85:1990;1599-1602.
3. Beranek, J.T., De Cato, L., Adler, F.L., 1976. Binding of morphine by serum immunoglobulins from morphine treated rabbits. Int. Arch. Allergy Appl. Immunol. 51, 298-310 and 402-415.
4. 3. Life Sci. 15:1974;1017-1028.
5. 131 metabolism in 190 human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects. J. Clin. Invest. 35:1956;170-190.
6. Biagini R.E., Klincewicz S.L., Henningsen G.M., MacKenzie B.A., Gallagher J.S., Bernstein D.I., Bernstein I.L. Antibodies to morphine in workers exposed to opiates at a narcotic manufacturing facility and evidence for similar antibodies in heroin abusers. Life Sci. 47:1990;897-908.
7. De Cato L. Jr., Adler F.L. Neutralisation of morphine activity by antibody. Res. Commun. Chem. Pathol. Pharmacol. 5:1973;775-788.
8. Friguet B., Chaffotte A.F., Djavadi-Ohaniance L., Goldberg M.E. Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay. J. Immunol. Methods. 77:1985;305-319.
9. Gamaleya N.B. Antibodies to drugs as indicators of chronic drug use. An alternative to toxicological hair analysis. Forensic Sci. Int. 63:1993;285-293.
10. Gamaleya N.B., Yelagina E.I., Levi M.I., Parshin A.N. Detection of morphine antibodies in the sera of opiate addicts by ELISA with beta-lactamase. Voprosy Narkologii. 3:1991;10-13. (in Russian).
11. Gamaleya N.B., Mondrus K.A., Tronnikov S.I., Gorshkova E.P., Eremina R.V. Towards the mechanisms of participation of immune system in the pathogenesis of opiate dependence. Voprosy Narkologii. 34:1992;113-115. (in Russian).
12. Gamaleya N.B., Parshin A.N., Tronnikov S.I., Yusupov D.V. Induction of antibodies to morphine during chronic morphine treatment in rodents and opiate addicts. Drug Alcohol Depend. 32:1993;59-64.
13. Gamaleya N., Tagliaro F., Parshin A., Vrublevskii A., Bugari G., Dorizzi R., Ghielmi S., Marigo M. Immune response to opiates: new findings in heroin addicts investigated by means of an original enzyme immunoassay and morphine determination in hair. Life Sci. 53:1993;99-105.
14. Gamaleya N., Tronnikov S., Ulyanova L., Klimova S., Dmitrieva I. Antibodies to morphine as indicators of chronic morphine intoxication and impaired immune reactivity. Addict. Biol. 1:1996;437-445.
15. Herndon B.L., Baeder D.H., Ringle D.A. Specific serum binding of morphine, levorphanol and heroin. Clin. Exp. Immunol. 23:1976;367-372.
16. 14C -morphine with sera from immunised rabbits and from patients addicted to heroin Clin. Exp. Immunol. 15:1973;213-224.
17. Hill J.H., Wainer B.H., Fitch F.W., Rothberg R.M. Delayed clearance of morphine from the circulation of rabbits immunised with morphine-6-hemisuccinate bovine serum albumin. J. Immunol. 114:1975;1363-1368.
18. Husby G., Pierce P.E., Williams R.C. Smooth muscle antibody in heroin addicts. Ann. Int. Med. 83:1975;801-805.
19. Judis J. Binding of codeine, morphine and methadone to human serum proteins. J. Pharm. Sci. 66:1977;802-806.
20. Kreek M.J. Plasma and urine levels of methadone. Ann. New York Acad. Sci. 73:1973;2773-2777.
21. Liu C.-T., Adler F.L. Immunologic studies on drug addiction: I. Antibodies reactive with methadone and their use for detection of the drug. J. Immunol. 111:1973;472-477.
22. Loimer N., Schmid R. The use of plasma levels to optimise methadone maintenance treatment. Drug Alcohol Depend. 30:1992;241-246.
23. Martinez F., Watson R.R. Effects of cocaine and morphine on IgG production by human peripheral blood lymphocytes in vitro. Life Sci. 47:1990;59-64.
24. Myagkova M.A., Lushnikova M.V., Polevaya O.Y. Immunochemical properties of human natural and induced antibodies against morphine. Voprosi Narcologii. 4:1989;7-11. (in Russian).
25. Ringle D.A., Herndon B.L. Immunologic effects of morphine administration in rabbits. J. Immunol. 115:1975;876-883.
26. Rothschield M.A., Kreek M.J., Oratz M., Schreiber S.S., Mongelli J.G. The stimulation of albumin synthesis by methadone. Gastroenterology. 71:1976;214-220.
27. Ryan J.J., Parker C.W., Williams R.C. γ-Globulin binding of morphine in heroin addicts. J. Lab. Clin. Med. 80:1972;155-164.
28. Schmidt D.H., Kaufman B.M., Butler V.P. Persistence of hapten-antibody complexes in the circulation of immunised animals after a single intravenous injection of hapten. J. Exp. Med. 139:1974;278-294.
29. Spector S., Berkowitz B., Flynn E.J., Peskar B. Antibodies to morphine, barbiturates and serotonin. Pharmacol. Rev. 25:1973;281-291.
30. Spiera H., Oreskes I., Stimmel B. Rheumatoid factor activity in heroin addicts on methadone maintenance. Ann. Rheum. Dis. 33:1974;153-156.
31. Tennant F.S. Inadequate plasma concentrations in some high-dose methadone maintenance patients. Am. J. Psychiatry. 144:1987;1349-1350.
32. Tocque B., Pontikis R., Nam N.-H., Hoellinger H., Leroux Y. Morphine and methadone binding to human serum proteins. J. Pharm. Pharmacol. 32:1980;729-731.
33. Tronnikov S.I., Gamaleya N.B., Veretinskaya A.G., Borisova E.V., Sudakov S.K., Anokhina I.P. Induction of antibodies to morphine and neurotransmitters in morphine-treated rats. Bull. Exp. Biol. Med. 114:1992;624-626.
34. Wainer B.H., Fitch F.W., Rothberg R.M., Schuster C.R. In vitro morphine antagonism by antibodies. Nature, London. 241:1973;537-538.
35. Waldhaus W.K., Bratusch-Marrain P., Kruse V., Jensen I., Nowotny P., Vierhapper H. Effect of insulin antibodies on insulin pharmacokinetics and glucose utilisation in insulin-dependent diabetic patients. Diabetes. 34:1985;166-173.
36. Weksler M.E., Cherubin C., Kilcoyne M., Koppel G., Yoel M. Absence of morphine-binding activity in serum from heroin addicts. Clin. Exp. Immunol. 13:1973;613-617.
37. Woodhouse N.J., Mohamedally S.M., Saed-Nejad F., Martin T.J. Development and significance of antibodies to salmon calcitonin in patients with Paget's disease on long-term treatment. Br. Med. J. 2:1977;927-929.