Chlorambucil in severe juvenile chronic arthritis: Longterm followup with special reference to amyloidosis

Journal of Rheumatology

Volumn 26, Issue 4, 1999, Pages 898-903

  Savolainen, H Anneli ^a  

^a RHEUMATISM FOUNDATION HOSPITAL   (Finland)

Author keywords

Amyloidosis; Chlorambucil; Cytotoxic Drugs; Iridocyclitis; Juvenile Chronic Arthritis; Juvenile Rheumatoid Arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; AZATHIOPRINE; CHLORAMBUCIL; CYCLOSPORIN; GAMMA INTERFERON; GLUCOCORTICOID; GOLD; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; LEVAMISOLE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLAMINE; PHENYLBUTAZONE; PODOPHYLLOTOXIN; SALAZOSULFAPYRIDINE; TIABENDAZOLE; TRANSFER FACTOR;

ADOLESCENT; AMYLOIDOSIS; ARTICLE; CHILD; CHRONIC DISEASE; DRUG INDUCED DISEASE; FEMALE; FOLLOW UP; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; IRIDOCYCLITIS; JUVENILE RHEUMATOID ARTHRITIS; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RASH; RELAPSE; REMISSION; RHEUMATOID ARTHRITIS; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADOLESCENT; AMYLOIDOSIS; ANTINEOPLASTIC AGENTS, ALKYLATING; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; CHILD, PRESCHOOL; CHLORAMBUCIL; FEMALE; FERTILITY; FOLLOW-UP STUDIES; HUMANS; IRIDOCYCLITIS; MALE; REMISSION INDUCTION; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0032943483     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Schnitzer RG, Ansell BM. Amyloidosis in juvenile chronic polyarthritis. Arthritis Rheum 1977;20:245-52.
2. Prieur AM, Balafrej M, Griscelli C, Mozziconacci P. Traitement par les immunosuppresseurs des rhumatismes inflammatoires chroniques de l'enfant [Immunosuppressive agents in treatment of chronic childhood inflammatory arthritis]. Arch Franc Pediatr 1977;34:783-7.
3. Dolgopolova AV, Melikhova NI. Late observations of children receiving leukeran in rheumatoid arthritis (Russian). Pediatrija 1981;3:46-8.
4. Jakovleva AA, Krasnova KN, Tsentsikova EP, Vjalutskina MD. Chlorbutin in the treatment of progressing rheumatoid arthritis in children (Russian with English summary). Voprosy Revmatizma 1981;2:22-5.
5. David J, Vouyiouka O, Ansell BM, Hall A, Woo P. Amyloidosis in juvenile chronic arthritis: a morbidity and mortality study. Clin Exp Rheumatol 1993;11:85-90.
6. Prieur AM, Balafrej M, Griscelli C, Mozziconacci P. Resultats et risques a long terme des traitements immunosuppresseurs dans l'arthrite chronique juvenile [Outcome and longterm risk in immunosuppressive treatment of juvenile chronic arthritis]. A propos de 40 observations. Rev Rhum 1979;46:85-90.
7. Wood PH. Nomenclature and classification of arthritis in children. In: Munthe E, editor. The care of rheumatic children. Basel: EULAR, 1978:47-50.
8. Prader A, Largo RH, Molinari RL, Isler C. Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development. Helv Paediatr Acta 1988;44 Suppl 52:1-125.
9. Kauppi MJ, Savolainen HA, Anttila VJ, Isomaki HA. Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil. Acta Paediatr 1996;85:248-50.
10. Chiappelli F, Myers LW, Ellison GW, Liao D, Fahey JL. Preferential reductions in lymphocyte subpopulations induced by monthly pulses of chlorambucil. J Immunopharmacol 1991;13:455-61.
11. Bontoux D, Kahan A, Brouilhet H, et al. Effect and mode of action of chlorambucil in rheumatoid disease. Value of the lymphoblast transformation test. Rev Rhum Mal Osteoartic 1971;38:759-64.
12. Savolainen HA, Kautiainen H, Isomäki HA, Aho K. Azathioprine in patients with juvenile chronic arthritis: a longterm followup study. J Rheumatol 1997;24:2444-50.
13. Mehra R, Moore RL, Catalano JD, Neucks SH, Zuckner J. Chlorambucil in the treatment of iridocyclitis in juvenile rheumatoid arthritis. J Rheumatol 1981;8:141-4.
14. Wegelius O, Wafin F, Falck H, Törnroth T. Follow-up study of amyloidosis secondary to rheumatic disease. In: Glenner GG, Costa PP, Freitas F, editors. Amyloid and amyloidosis. Amsterdam: Excerpta Medica; 1980:183-90.
15. Gertz MA, Kyle RA. Amyloidosis: prognosis and treatment. Semin Arthritis Rheum 1994;24:124-38.
16. Ahlmen M, Ahlmen J, Svalander C, Bucht H. Cytotoxic drug treatment of reactive amyloidosis in rheumatoid arthritis with special reference to renal insufficiency. Clin Rheumatol 1987;6:27-38.
17. Savolainen HA, lsomäki HA. Decrease in the number of deaths from secondary amyloidosis in patients with juvenile rheumatoid arthritis. J Rheumatol 1993;20:1201-3.
18. Wallace CA, Levinson JE. Juvenile rheumatoid arthritis: outcome and treatment for the 1990s. Rheum Clin North Am 1991;17:871-89.
19. Laaksonen AL. A prognostic study of juvenile rheumatoid arthritis. Acta Paediatr Scand 1966;55 Suppl 166:1-91.
20. Michels H, Häfner R, Morhart R, Schuchman L, Truckenbrodt H. Five year follow-up of a prospective cohort of juvenile chronic arthritis with recent onset. Clin Rheumatol 1987;6 Suppl 12:87-92.
21. Ansell BM, Wood PHN. Prognosis in juvenile chronic polyarthritis. Clin Rheum Dis 1976;2:397-412.
22. Palmer RG, Kanski JJ, Ansell BM. Chlorambucil in the treatment of intractable uveitis associated with juvenile chronic arthritis. J Rheumatol 1985;12:967-71.
23. Pascalis L, Pia G, Aresu G, Frongia T, Barca L. Combined cyclosporin-A-steroid-MTX treatment in endogenous non-infectious uveitis. J Autoimmunity 1993;6:467-80.
24. Ansell BM, Bywaters EGL. Growth in Still's disease. Ann Rheum Dis 1956;15:295-314.
25. Palmer RG, Doré CJ, Denman AM. Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative. Lancet 1984;4:246-9.
26. Hawkins PN. Diagnosis and treatment of amyloidosis. Ann Rheum Dis 1997;56:631-3.
27. Woo P. Amyloidosis in children. Baillieres Clin Rheumatol 1994;8:691-7.