The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release

Immunopharmacology

Volumn 41, Issue 1, 1999, Pages 11-20

  Balog, Tihomir ^a   Marotti, Tanja ^a   Abramić, Marija ^a   Svoboda Beusen, Ivna ^b   Hršak, Ivo ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b INSTITUTE OF IMMUNOLOGY   (Croatia)

Author keywords

APN activity; Met enkephalin; Neutrophils; Respiratory burst

Indexed keywords

BESTATIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; METENKEPHALIN; MICROSOMAL AMINOPEPTIDASE; PROBESTIN; SUPEROXIDE;

ARTICLE; CELL SURFACE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; RESPIRATORY BURST; SWINE;

ADULT; ANALGESICS; ANALGESICS, OPIOID; ANTIGENS, CD13; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALIN, METHIONINE; ENKEPHALINS; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; LEUCINE; MALE; NEUTROPHILS; OLIGOPEPTIDES; PROTEASE INHIBITORS; SUPEROXIDES;

EID: 0032942621     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(98)00050-2     Document Type: Article

References (31)

1. Amoscato A.A., Wesley A.J., Babcock G.F. Surface aminopeptidase activity of human lymphocytes: I. Biochemical and biologic properties of intact cells. J. Immunol. 142:1989;1245-1252.
2. Amoscato A.A., Spiess R.P., Sansoni S.B., Herberman R.B., Chambers W.H. Degradation of enkephalins by rat lymphocyte and purified rat natural killer cell surface aminopeptidases. Brain Behav. Immun. 7:1993;176-187.
3. Ansorage S., Schon E., Kunz D. Membrane bound peptidases of lymphocytes: functional implications. Biomed. Biochim. Acta. 50:1991;799-807.
4. 5)-enkephalin by bestatine-sensitive aminopeptidase, captopril-sensitive peptidil dipeptidase A and thiorphan-sensitive endopeptidase 24.11. in mouse vas deferens. Jap. J. Pharmacol. 40:1986;297-302.
5. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21:1968;77-89.
6. Burgos C., Gerez de Burgos N.M., Coronel C.E., Blanco A. Supstrate specificity of the lactate dehydrogenase isoenzyme C4 from human spermatozoa and a possible selective assay. J. Reprod. Fertil. 55:1979;101-106.
7. Churchill L., Bausback H.H., Gerritsen M.E., Ward P.E. Metabolism of opioid peptides by cerebral microvascular aminopeptidase M. Biochim. Biophys. Acta. 923:1987;35-41.
8. Haberstock H., Marotti T., Banfić H. Neutrophil signal transduction in Met-enkephalin modulated superoxide anion release. Neuropeptides. 30:1996;1-9.
9. Hazato T., Shimamura M., Katayama T., Kasama A., Nishioka S., Kaya K. Enkephalin degrading enzymes in cerebrospinal fluid. Life Sci. 33:1983;443-448.
10. Johnson R.B., Godzik C.A., Cohn Z.A. Increased superoxide anion production by immunologically activated and chemically elicited macrophages. J. Exp. Med. 148:1978;115-127.
11. Johnson, A.M., Downs, M.O., Pontzer, C.H., 1992. Neuroendocrine peptide hormone regulation of immunity. In: Blalock, J.E. (Ed.), Neuroimmunoendocrinology and Chemical Immunology 52. Basel, Karger, pp. 49-83.
12. Keith D.E., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Kang L., Evans C.J., von Zastrow M. Morphine activates opioid receptors without causing their rapid internalization. J. Biol. Chem. 271:1996;19021-19024.
13. Kunz D., Buhling F., Hutter H.J., Aoyagi T., Ansorage S. Aminopeptiase N (CD13, EC 3.4.11.2) occurs on the surface of resting and concanavalin A-stimulated lymphocytes. J. Biol. Chem. 374:1993;291-296.
14. Lolait, S.J., 1991. Production of opioid peptides by immunocompetent cells and potential role of these cytokines in the stress response. In: Plotnikoff, N.P., Murgo, A.J., Faith, R.E., Wybran, J. (Eds.), Stress and Immunity. CRC Press, Boca Raton, FL.
15. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:1951;256-275.
16. Marini M., Roscetti G., Bongiorno L., Urbani A., Roda G.L. Hydrolysis and protection from hydrolysis of enkephalin in human plasma. Neurochem. Res. 15:1990;61-67.
17. Marotti T., Haberštok H. Naloxone is an inappropriate antagonist of Met-enkephalin-modulated superoxide anion release. Brain Behav. Immun. 6:1992;223-233.
18. Marotti T., Šverko V., Hršak I. Modulation of superoxide anion release from human polymorphonuclear cells by Met- and Leu-enkephalin. Brain Behav. Immun. 4:1990;13-22.
19. Marotti T., Gabrilovac J., Haberstock H., Rabatić S., Šmejkal-Jagar L., Ročić B. Met-enkephalin modulates stress-induced alterations of the immune response in mice. Pharmacol. Biochem. Behav. 54:1996;277-284.
20. Matasas R., Stephenson S.L., Hryszko J., Kenny A.J., Turner A.J The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N. Biochem. J. 231:1985;445-449.
21. + spleen T cells. Arch. Biochem. Biophys. 311:1994;174-179.
22. Plotnikoff N.P., Faith R.E., Murgo A.J., Herberman R.B., Good R.A. Methionine enkephalin: a new cytokine-human studies. Clin. Immunol. Immunopathol. 82:1997;93-101.
23. Saito M., Kumagai M., Okazaki T., Nakazawa S., Shapiro L.H., Look A.T., Campana D. Stromal cell-mediated transcriptional regulation of the CD 13/aminopeptidase N gene in leukemic cells. Leukemia. 9:1995;1508-1516.
24. Shibanoki S., Weinberger S.B., Beniston D., Nudelman K.A., Shulteis G., Bennet E.L., Rosenzweig M.R., Ishikawa K., Martinez J.L. Hydrolysis of Met-enkephalin by chick plasma in vitro. J. Pharmacol. Exp. Ther. 256:1991;650-655.
25. Shibanoki S., Weinberger S.B., Ishikawa K., Martinez J.L. Jr. Further characterization of the in vitro hydrolysis of Leu- and Met-enkephalin in rat plasma: HPLC-ECD measurement of substrate and metabolite concentrations. Regulatory Peptides. 32:1991;267-278.
26. Shibanoki S., Weinberger S.B., Schulteis G., Ishikawa K., Martinez J.L. Jr. Enkephalin hydrolysis by mouse plasma in vitro. Life Sci. 50:1992;667-675.
27. Suda H., Aoyagi T., Takeuchi T., Umezawa H. Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer. Arch. Biochem. Biophys. 177:1976;196-200.
28. Turner A.J., Matsas R., Kenny A.J. Are there neuropeptide-specific peptidases? Biochem. Pharmacol. 34:1985;1347-1356.
29. Vukelic V., Svoboda-Beusen I. Flow-cytometric lymphocyte phenotyping using automated simulset software gating procedure. Acta Med. Croatica. 48:1994;67-72.
30. Wex T., Lendeckel U., Kahne T., Ittenson A., Frank K., Ansorage S. The main neutral aminopeptidase activity of human lymphoid tumour cell lines does not originate from the amoinopeptidase N (APN CD13) gene. Biochim. Biophys. Acta-Mol. Cell Res. 1355:1997;147-154.
31. Xu Y., Wellner D., Scheinberg D.A. Substance P and bradykinin are natural inhibitors of CD13/Aminopeptidase N. Biochem. Biophys. Res. Commun. 208:1995;664-674.