A controlled clinical study comparing doxapram and theophylline in the treatment of apneas of prematurity;Vergleichende untersuchung zur wirkung von theophyllin und doxapram bei apnoen

Klinische Padiatrie

Volumn 211, Issue 2, 1999, Pages 86-91

  Moller J C ^a   Austing, A ^a   Pust B ^a   Kohl, M ^a   Reiss, I ^a   Iven, H ^a   Gortner, L ^a  

^a NONE

Author keywords

Apneas; Bradycardias; Doxapram; Preterm infants; Theophylline

Indexed keywords

AMINOPHYLLINE; DOXAPRAM; THEOPHYLLINE;

APNEA; ARTICLE; BRADYCARDIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; FEMALE; GESTATIONAL AGE; HUMAN; MALE; NEWBORN; PREMATURITY;

EID: 0032942451     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1043772     Document Type: Article

References (34)

1. 1 Albani, M., K. H. P. Bentele, C. Budde, F. J. Schulte: Infant sleep apnea profile: preterm vs. term infants. Eur. J. Pediatr. 143 (1985) 261-268
2. 2 Alpan, G., F. Eyal, E. Sagi, C. Springer, D. Patz, K. Goder: Doxapram in the treatment of idiopathic apnea of prematurity unresponsive to aminophylline. J. Pediatr. 104 (1984) 634-637
3. 3 Anderson-Beck, R., L. Wilson, S. Brazier, I. E. Hughes, C. Peers: Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neuroscience letters 187 (1995) 25-28
4. 4 Aranda, J. V., A. Mandelberg, K. Beharry, J. Rex, O. Peleg, F. Eyal: Metabolism of doxapram in premature newborns. Pediatr. Res. 21 (1987) 232A
5. 5 Aranda, J. V., D. S. Sitar, W. D. Parsons, P. M. Loughnan, A. H. Neims: Pharmacokinetic aspects of theophylline in premature newborns. N. Engl. J. Med. 295 (1976) 413-416
6. 6 Bairam, A., K. Beharry, N. Laudignon, J. Rex, C. Branchaud, A. Papageorgiou, J. V. Aranda: Metabolism of doxapram in human fetal liver organ culture. Pediatr. Res. 25 (1989a) 64A
7. 7 Bairam, A., P. W. Blanchard, N. Laudignon, K. Mullahoo, K. Beharry, J. Rex, J. V. Aranda Interaction of doxapram and coffeine on ventilation in the newborn. 25 (1986b) 207A
8. 8 Bairam, A., P. W. Blanchard, K. Mullahoo, K. Beharry, N. Laudignon, J. V. Aranda: Pharmacodynamic effects and pharmacokinelic profiles of ketodoxapram and doxapram in newborn lambs. Pediatr. Res. 28 (1990) 142-146
9. 9 Bairam, A., M. Faulton, P. Monin, P. Vert: Doxapram for the initial treatment of idiopathic apnea of prematurity. Biol. Neonate 61 (1992) 209-213
10. 10 Bairam, A., F. Marchal, J. P. Crance, P. Vert, S. Lahiri: Effects of doxapram on carotid chemoreceptor activity in newborn kittens. Biol. Neonate 64 (1993) 26-35
11. 11 Bairam, A., P. Vert: Low-dose doxapram for apnea of prematurity. Lancet 5 (1986) 793-794
12. 12 Barrington, K. J., N. N. Finer, K. L. Peters, J. Barton: Physiologic effects of doxapram in idiopathic apnea of prematurity. J. Pediatr. 108 (1986a) 125-129
13. 13 Barrington, K. J., N. N. Finer, G. Torok-Both, F. Jamali, R. T. Coutts: Dose-response relationship of doxapram in the therapy for refractory idiopathic apnea of prematurity. Pediatrics 80 (1987) 22-27
14. 14 Barrington, K. J., G. Torok-Both, F. Jamali, N. Finer: Kinetics of doxapram in the premature neonate. Pediatr. Res. 20 (1986b) 201A
15. 15 Beaudry, M. A., J. M. Bradley, L. M. Gramilch, D. Lyaff: Pharmacokinetics of doxapram in idiopathic apnea of prematurity. Dev. Pharmacol. Ther. 11 (1988) 65-72
16. 16 Cote, A, P. W. Blanhard, B. Meehan: Metabolic and cardiorespiratory effects of doxapram and theophylline in sleeping newborn piglets. J. Appl. Physiol. 72 (1992) 410-415
17. 17 Eyal, F., G. Alpan, E. Sagi, B. Glick, O. Peleg, Y. Dgani, I. Arad: Aminophylline versus doxapram in idiopathic apnea of prematurity: A double-blind controlled study. Pediatrics 75 (1985) 709-713
18. 18 Hayakawa, F.: Doxapram for apnea of prematurity. J. Pediatr. 111 (1987) 154
19. 19 Hayakawa, F., S. Hakamada, K. Kuno, T. Nakashima, Y. Miyachi: Doxapram in the treatment of idiopathic apnea of prematurity: Desirable dosage and serum concentration. J. Pediatr. 109 (1986) 138-140
20. 20 Henderson-Smart, D. J., A. G. Peffigrew, D. J. Campbell: Clinical apnea and brain-stem neural function in preterm infants. N. Engl. J. Med. 308 (1983) 353-357
21. 21 Jamali, F., K. J. Barrington, N. N. Finer, R. T. Couffs, G. A. Torok-Both: Doxapram dosage regimen in apnea of prematurity based on pharmacokinetic data. Dev. Pharmacol. Ther. 11 (1988) 253-257
22. 22 Kohl, M., M. Burbaum, I. Reiss, L. Gortner, A. Pollak, J. C. Möller: Apneas and bradycardias in small for gestational (SG-a) compared with appropriate for gestational age (AGA) very-low-birth-weight (VLBW) infants. Eur. Respir. J. 10 (Suppl 25) (1997) 306s
23. 23 Kohl, M., H. Iven, Th. Schaible, J. Möller: Enteral Doxapram in the treatment of apnea of prematurity. Annual Meeting of the ESPIC, Lyon, August 1996
24. 24 Lagercrantz, H.: What does the preterm infant breathe for? Controversies on apnea of prematurity. Acta Paediatr. 82 (1992) 733-736
25. 25 Möller, J. C., M. Burbaum, M. Kohl, I. Reiss, L. Gortner, A. Pollak: Cardiorespiratory instability (apneas, bradycardias and desaturation) in very low birth weight infants before and under therapy with nasal CPAP in relation to cerebral pathology (IVH; PVL, and normal infants compared) Eur. Respir. J. 10 (Suppl 25) (1997) 343s
26. 26 Möller, J. C., T. H. Rose: Linksventrikuläre Funktionsparameter in der M-Mode-Echocardiographie bei unterschiedlicher Applikations-geschwindigkeit einer Theophyllinsättigungsdosis bei Frühgeborenen. Monatsschr. Kinderheilkd. 137 (1989) 33-36
27. 27 Möller, J. C., B. Püst, A. gr. Austing, I. Reiss, M. Kohl, L. Gortner: Management der kardiorespiratorischen Instabilität (Apnoen, Bradykardien, Entsättigungen) bei sehr kleinen Frühgeborenen. Perinatal-Medizin 10 (1998) 24-32
28. 28 Möller, J. C., S. Schuff, M. Herkenhoff, T. F. Schaible, L. Gortner: Qualitätskontrolle in der Versorgung sehr kleiner Frühgeborener - Effekte der Einrichtung eines Perinatalzentrums auf Letalität, Morbidität und Therapieeffizienz. In: Abstrakte des 22. Symposiums der Deutsch-Österreichischen Gesellschaft für Neonatologie und Intensivmedizin, Dresden, 19.-21. September 1996, Acron-Verlag GmbH, Berlin (1997) 177
29. 29 Nolte, R.: Spontane Verhaltensweisen und bioelektrische Aktivität als Indikatoren der Hirnentwicklung Frühgeborener. Eine polygraphische Untersuchung. Fortschr. Med. 102 (1984) 272-276
30. 30 Perlman, J. M., J. J. Volpe: Episodes of apnea and bradycardia in the preterm newborn: Impact on cerebral circulation. Pediatrics 76 (1985) 333-338
31. 31 Poets, C. F.: Apnoen bei Frühgeborenen; Epidemiologie, Pathophysiologic und Präventionsmöglichkeiten. Monatsschr. Kinderheilkd. 141 (1993a) 558-566
32. 32 Prechtl, H. F. R.: The behavioural states of the newborn infant (a review). Brain Res. 76 (1974) 185-212
33. 33 Sagi, E., F. Eyal, G. Alpan, D. Patz, I. Arad: Idiopathic apnea of prematurity treated with doxapram and aminophylline. Arch. Dis. Child. 59 (1984) 281-283
34. 34 Ylppö, A.: Zur Physiologie, Klinik und zum Schicksal der Frühgeborenen. Zeitschrift für Kinderheilkunde 24 (1919) 1-105