Effect of codeine on oro-cecal transit time in Chinese healthy volunteers in comparison with Caucasian subjects

European Journal of Clinical Pharmacology

Volumn 54, Issue 11, 1999, Pages 839-842

  Yue, Q Y ^a   Hasselstrom J ^b   Svensson, J O ^a   Sawe J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Codeine; Lactulose hydrogen breath test; Oro cecal transit time

Indexed keywords

CODEINE;

ADULT; ARTICLE; CAUCASIAN; CHINESE; DRUG ABSORPTION; DRUG ELIMINATION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROGEN BREATH TEST; INTESTINE TRANSIT TIME; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RACE DIFFERENCE;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BREATH TESTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CODEINE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN; LACTULOSE; MALE; PLACEBOS;

EID: 0032942276     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050563     Document Type: Article

References (22)

1. 2) breath test as compared with a radiologic control method. Scand J Gastroenterol 21: 669-677
2. Borody TJ, Quigley EMM, Phillips SF, Wienbeck M, Tucker RL, Haddad A, Zinsmeister AR (1985) Effects of morphine and atropine on motility and transit in the human ileum. Gastroenterology 89: 562-570
3. Burks TF, Galligan JJ, Himing LD, Porreca F (1987) Brain, spinal cord and peripheral sites of action of enkephalins and other endogenous opioids on gastrointestinal motilily. Gastroenterol Clin Biol 11: 44B-51B
4. Clarkston WK, Pantano MM, Morley JE, Horowitz M. Littlefield JM, Burton FR (1997) Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Physiol 272: R243-248
5. Hasselström J, Yue QY, Säwe J (1997) The effect of codeine on gastrointestinal transit in extensive and poor hydroxylators of debrisoquine. Eur J Clin Pharmacol 53: 145-148
6. Johansson I, Yue QY, Dahl ML, Heim M, Säwe J, Bertilsson L, Meyer UA, Sjöqvist F, Ingeiman-Sundberg M (1991) Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine. Eur J Clin Pharmacol 40: 553-556
7. Kalow W, Bertilsson L (1994) Interethnic factors affecting drug response. In advances in drug research eds Testa B, Meyer UA, vol 25. Academic Press, London pp 1-53
8. Knox VJ, Shum K, McLaughlin DM (1977) Response to cold pressor pain and to accupuncture analgesia in oriental and occidental subjects. Pain 4: 49-57
9. Manara L, Bianchetti A (1985) The central and peripheral influences of opioids on gastrointestinal propulsion. Ann Rev Pharmacol Toxicol 25: 249-273
10. O'Brien JD, Thompson DG, McIntyre A, Burnham WR, Walker E (1988) Effect of codeine and loperamide on upper intestinal transit and absorption in normal subjects and patients with postvagotomy diarrhoea. Gut 29: 312-318
11. Patel VP, Jain NK, Pitchumoni CS (1986) Factors affecting fasting breath hydrogen levels in healthy adults: a study in two continents. Am J Gastroenterol 81: 771-773
12. 2) production. Dig Dis Sci 33: 308-313
13. Sawynok J (1995) Pharmacological rationale for the clinical use of caffeine. Drugs 49: 37-50
14. Schiller LR, Davis GR, Santa Ana CA, Morawski SG, Fordtran JS (1982) Studies of the mechanism of the antidiarrheal effect of codeine. J Clin Invest 70: 999-1008
15. Svensson JO, Yue QY, Säwe J (1995) Determination of codeine and metabolites in plasma and urine using ion-pair HPLC. J Chromatogr Biomed Sci Appl 674: 49-55
16. Wald A, van Thiel DH, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R (1981) Gastrointestinal transit: the effect of the menstrual cycle. Gastroenterology 80: 1497-1500
17. Yue QY, Svensson JO, Alm C, Sjöqvist F, Säwe J (1989a) Inter-individual and interethnic differences in the demethylation and glucuronidation of codeine. Br J Clin Pharmacol 28: 629-637
18. Yue QY, Svensson JO, Alm C, Sjöqvist F, Säwe J (1989b) Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation. Br J Clin Pharmacol 28: 638-645
19. Yue QY, Hasselström J, Svensson JO, Säwe J (1991a) Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers. Comparisons between extensive and poor hydroxylators of debrisoquine. Br J Clin Pharmacol 31: 635-642
20. Yue QY, Svensson JO. Sjöqvist F, Sawe J (1991b) A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine. Br J Clin Pharmacol 31: 643-647
21. Yue QY, Tomson T, Säwe J (1994) Inductive effects of carbamazepine and cigarette smoking on codeine metabolism in man. Pharmacogenetics 4: 193-198
22. Zhou HH, Sheller JR, Wood M, Wood AJJ (1993) Ethnic differences in response to morphine. Clin Pharmacol Ther 54: 507-513