Topical budesonide treatment reduces endothelial expression of intercellular adhesion molecules (vascular cell adhesion molecule-1 and p- selectin) and eosinophil infiltration in nasal polyps

Acta Oto-Laryngologica

Volumn 119, Issue 3, 1999, Pages 362-368

  Tingsgaard, P K ^a,b   Bock, T ^b   Larsen, P L ^c   Tos, M ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b Kommunehospitalet ^*  (Denmark)

^c HILLERØD HOSPITAL   (Denmark)

Author keywords

Budesonide; Endothelial cells; Eosinophil granulocytes; Immunohistochemistry; Nasal polyposis; P selectin; Stereological microscopy; VCAM 1

Indexed keywords

BUDESONIDE; GLUCOCORTICOID RECEPTOR; PADGEM PROTEIN; STEROID; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOTHELIUM CELL; EOSINOPHIL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; INHALATIONAL DRUG ADMINISTRATION; MALE; MICROSCOPY; NOSE POLYP; PRIORITY JOURNAL; STEREOMETRY; STEROID THERAPY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; AGED; ANTI-INFLAMMATORY AGENTS; BIOPSY; BUDESONIDE; ENDOTHELIUM; EOSINOPHILIA; EOSINOPHILS; FEMALE; GLUCOCORTICOIDS; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; NASAL POLYPS; P-SELECTIN; TURBINATES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0032941963     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016489950181404     Document Type: Article

References (25)

1. Larsen PL, Tos M. Origin and structure of nasal polyps. In: Mygind N, Lildholt T, eds. Nasal polyposis - an inflammatory disease and its treatment. Copenhagen: Munksgaard, 1997: 17-30.
2. Hellquist HB. Nasal polyps update. Histopathology. Allergy and Asthma Proc 1996; 17: 237-42.
3. Kakoi H, Hiraide F. A histological study of formation and growth of nasal olyps. Acta Otolaryngol (Stockh) 1987; 103: 137-44.
4. Settipane GA. Epidemiology of nasal polyps. Allergy and Asthma Proc 1996; 17: 231-6.
5. Larsen PL, Tingsgaard PK, Harcourt J, Sofsrud G, Tos M. Nasal polyps and their relation to polyps hypertrophic polypoid mucosa in the paranasal sinuses: a macro-, endo-, and microscopic study of autopsy materials. Am J Rhinol 1998; 12: 45-51.
6. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-14.
7. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994; 8: 504-12.
8. 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol 1997; 159: 3929-39.
9. Tingsgaard PK, Larsen PL, Bock T, Lange Vejlsgaard G, Tos M. Expression of intercellular adhesion molecule-1 on the vascular endothelium in nasal polyps before, during and after topical glucocorticoid treatment. Acta Otolaryngol (Stockh) 1998; 118: 404-8.
10. Jahnsen FL, Haraldsen G, Aanesen JP, Haye R, Brashler JR. Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps. Am J Respir Cell Mol Biol 1995; 12: 624-32.
11. Beck LA, Stellato C, Dawson Beall L, et al. Detection of the chemochine RANTES and endothelial adhesion molecules in nasal polyps. J. Allergy Clin Immunol 1996; 98: 766-80.
12. Fokkens WJ, Holm AF, Rijntjes E, Mulder PGH, Vroom TM. Characterization and quantification of cellular infiltrates in nasal mucosa of patients with grass pollen allergy, non-allergic patients with nasal polyps and controls. Int Arch Allergy Appl Immunol 1990; 93: 66-72.
13. Kanai N, Denburg J, Jordana M, Dolovich J. Nasal polyp inflammation. Effect of topical nasal steroid. Am Respir Crit Care Med 1994; 150: 1094-100.
14. Wardlaw AJ, Walsh GM, Symon FA. Adhesion interactions involved in eosinophil migration through vascular endothelium. Ann N Y Acad Sci 1996; 796: 124-37.
15. Sriramarao P, von Adrian UH, Butcher EC, Bourdon MA, Broide DH. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J Immunol 1994; 153: 4238-46.
16. Henriques GMO, Miotla JM, Corderio RSB, Wolitzky BA, Woolley ST, Hellewell PG. Selectins mediate eosinophil recruitment in vivo. A comparison with their role in neutrophil influx. Blood 1994; 87: 5297-304.
17. Hamilos DL, Leung DYM, Wood R, et al. Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-χ. Am J Respir Cell Mol Biol 1996; 15: 443-50.
18. Symon FA, Walsh GM, Watson SR, Wardlaw AJ. Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent. J Exp Med 1994; 180: 371-6.
19. Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann GA. Mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89: 9991-5.
20. Kaiser J, Bickl CA, Bochner BS, Schleimer RP. The effects of the potent glucocorticoid budesonide on adhesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules. J Pharmacol Exp Ther 1992; 267: 245-9.
21. Tessier PA, Cattaruzzi P, McColl SR. Inhibition of lymphocyte adhesion to cytochine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression. Arthritis Rheum 1996; 39: 226-34.
22. Perretti M, Wheller SK, Harris JG, Flower RJ. Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1β and dexamethasone. Biochem Biophys Res Com 1996; 223: 112-7.
23. Auphan NDJA, Rosette C, Helmberg A, Karin M. Immunosupression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 1995; 270: 286-90.
24. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of IκBχ in mediation of immunosuppression by glucocorticoids. Science 1995; 270: 283-6.
25. Manning AM, Bell FPRCL, Chosay JG, et al. NF-κB is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. J Inflammation 1995; 45: 283-96.