Effects of topical carteolol and timolol on tissue circulation in the iris and choroid

Current Eye Research

Volumn 18, Issue 5, 1999, Pages 381-390

  Tomidokoro, Atsuo ^a   Araie, Makoto ^b   Tamaki, Yasuhiro ^c   Muta, Kenji ^b  

^a SAITAMA RED CROSS HOSPITAL   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Carteolol; Choroid; Iris; Laser speckle method; Pigmented rabbit; Timolol; Uveal circulation

Indexed keywords

CARTEOLOL; SODIUM CHLORIDE; TIMOLOL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CHOROID; CONTROLLED STUDY; INTRAOCULAR PRESSURE; IRIS; NONHUMAN; ORGAN CIRCULATION; PRIORITY JOURNAL; PULSE RATE; RABBIT; TOPICAL DRUG ADMINISTRATION; VASCULAR RESISTANCE;

ADMINISTRATION, TOPICAL; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BLOOD CIRCULATION; BLOOD FLOW VELOCITY; CARTEOLOL; CHOROID; INTRAOCULAR PRESSURE; IRIS; RABBITS; TIME FACTORS; TIMOLOL; VASCULAR RESISTANCE;

EID: 0032941941     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.18.5.381.5352     Document Type: Article

References (33)

1. Caprioli J. The ciliary epithelia and aqueous humor. In: Hart W, ed. Adler's Physiology of The Eye 9th edition. CV Mosby, St. Louis. 1992;228-247.
2. Nies A, Evans G. and Shand D. Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primate. Am Heart J. 1973;85:97-102.
3. Cruickshank J. The clinical importance of cardioselectivity and lipophilicity in beta blockers. Am Heart J. 1980;100:160-178.
4. Araie M, Takase M, Sakai Y, Ishii Y, Yokoyama Y, Kitagawa M. Beta-adrenergic blockers: ocular penetration and binding to the uveal pigment. Jpn J Ophthalmol. 1982;26:248-263.
5. Fujio N, Kusumoto N, Odomi M. Ocular distribution of carteolol after single and repeated ocular instillation in pigmented rabbits. Acta Ophthalmol (Copenh). 1994;72:688-693.
6. Fujio N, Kitazawa T. Intraocular penetration of 14C-Carteolol hydrochloride (beta-blocker) in the albino rabbits. Nippon Ganka Gakkai Zasshi. 1984;88:236-241.
7. Elena PP, Kosina-Boix M, Moulin G, Lapalus P. Autoradiographic localization of beta-adrenergic receptors in rabbit eye. Invest Ophthalmol Vis Sci. 1987;28:1436-1441.
8. Kahle G, Kaulen P, Wollensak J. Quantitative autoradiography of beta-adrenergic receptors in rabbit eyes. Exp Eye Res. 1990;51:503-507.
9. Hoste A, Sys S. The relaxant action of betaxolol on isolated bovine retinal microarteries. Curr Eye Res. 1994;13:483-487.
10. Yabuuchi Y, Kinoshita D. Cardiovascular studies of 5-3-tert-butylamino-2-hydroxy, propoxy-3, 4-dyhydorocarbostyril hydrochloride OPC-1085, a new potent b-adrenergic blocking agent. Jpn J Pharmacol. 1974;24:853-861.
11. Chiba S. The inotropic and chronotropic responses of isolated canine atrium to 5-(3-tert, butylamino-lhydroxy) propoxy-3,4-dehydrocarbostyril hydrochloride (carteolol). Drug Res. 1979;29:895-897.
12. Man In' Veld A, Schalekamp M. How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta-adrenoreceptor antagonists, A clue to the nature of their antihypertensive mechanism. Br J Clin Pharmacol. 1982;13:245S-257S.
13. Janczewski P, Boulanger C, Iqbal A, Vanhoutte P. Endothelium-dependent effects of carteolol. J Pharmacol Exp. 1988;247:590-595.
14. Grunwald J, Delehanty J. Effect of topical carteolol on the normal human retinal circulation. Invest Ophthalmol Vis Sci. 1992;33:1853-1856.
15. Yamazaki S, Baba H. Acute effect of topical carteolol on ocular pulsatile volume change. Acta Ophthalmol (Copenh). 1993;71:760-764.
16. Tomidokoro A, Tamaki Y, Araie M, Tomita K, Muta K. Effect of topical carteolol on iridial circulation in pigmented rabbit eyes. Jpn J Ophthalmol. 1998;42:180-185.
17. Tamaki Y, Araie M, Kawamoto E, Eguchi S, Fujii H. Non-contact, two-dimensional measurement of microcirculation in choroid and optic nerve head using laser speckle phenomenon. Exp Eye Res. 1995;60:373-384.
18. Tomidokoro A, Araie M, Tamaki Y, Tomita K. In vivo measurement of iridial circulation using laser speckle phenomenon. Invest Ophthalmol Vis Sci. 1998;39:364-371.
19. Jay WM, Aziz MZ, Green K. Effect of topical epinephrine and timolol on ocular and optic nerve blood flow in phakic and aphakic rabbit eyes. Curr Eye Res. 1984;3:1199-1202.
20. Chiou GC, Watanabe K, McLaughlin MA, Liu HK. Are beta-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs? Ophthalmic Res. 1985;17:49-53.
21. Green K, Hatchett TL. Regional ocular blood flow after chronic topical glaucoma drug treatment. Acta Ophthalmol (Copenh). 1987;65:503-506.
22. Watanabe K, Chiou G. Action mechanism of timolol to lower the intraocular pressure in rabbits. Ophthalmic Res. 1983;15:160-167.
23. Van Buskirk E, Bacon D, Fahrenbach W. Ciliary vaso-constriction after topical adrenergic drugs. Am J Ophthalmol. 1990;109:511-517.
24. Fujii H, Nohira K, Yamamoto Y, Ikawa H, Ohura T. Evaluation of blood flow by laser speckle image sensing. Part 1. Appl Opt. 1987;26:5321-5325.
25. Kozuma C, Macklin W, Cumminus L, Mauer R. Anatomy, physiology, and biochemistry of the rabbit. In: Weisbroth S, Flatt R, Kraus A, ed. The Biology of the Laboratory Rabbit. Academic Press, New York. 1974;50-72.
26. Neutze J, Wyler F, Rudolph A. Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Am J Physiol. 1968;215:486-495.
27. Alm A. Ocular circulation. In: Hart W, ed. Adler's Physiology of The Eye 9th ed. C.V. Mosby, St. Louis. 1992;198-227.
28. Tamaki Y, Kawamoto E, Araie M, Eguchi S, Fujii H. Non-contact, two-dimensional measurement of retinal microcirculation using laser speckle phenomenon. Invest Ophthalmol Vis Sci. 1994;35:3825-3834.
29. Nagahara M, Tamaki Y, Araie M, Fujii H. Measurements of blood flow velocity in human retinal veins using laser speckle flowgraphy system. Nippon Ganka Gakkai Zasshi. 1997;101:173-179.
30. Altura B, Altura B, Carella A, Turlapaty P, Weinberg J. Vascular smooth muscle and general anesthetics. Fed Proc. 1980;39:1584-1591.
31. Schmidt C, Lotti V, LeDouarec J. Penetration of timolol into the rabbit eye, Measurements after ocular instillation and intravenous injection. Arch Ophthalmol. 1980;98:547-551.
32. Phillips CI, Bartholomew RS, Kazi G, Schmitt CJ, Vogel R. Penetration of timolol eye drops into human aqueous humour. Br J Ophthalmol. 1981;65:593-595.
33. Lee YH, Kompella UB, Lee VH. Systemic absorption pathways of topically applied beta adrenergic antagonists in the pigmented rabbit. Exp Eye Res. 1993;57:341-349.