Cardiovascular pharmacology of the adenosine A1/A2-receptor agonist AMP 579: Coronary hemodynamic and cardioprotective effects in the canine myocardium

Journal of Cardiovascular Pharmacology

Volumn 33, Issue 5, 1999, Pages 703-710

  McVey, Matthew J ^a   Smits, Glenn J ^a   Cox, Bryan F ^a   Kitzen, Jan M ^a   Clark, Kenneth L ^a   Perrone, Mark H ^a  

^a SANOFI   (France)

Author keywords

Adenosine; AMP 579; Canine; Cardioprotection; Coronary steal; Myocardial infarction

Indexed keywords

4 [7 [[2 (3 CHLORO 2 THIENYL) 1 METHYLPROPYL]AMINO] 3H IMIDAZO[4,5 B] PYRIDYL 3 YL]CYCLOPENTANE CARBOXAMIDE; ADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; CORONARY HEMODYNAMICS; DOG; HEART INFARCTION SIZE; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; CORONARY CIRCULATION; CORONARY DISEASE; DOGS; HEART; IMIDAZOLES; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PYRIDINES; RECEPTORS, PURINERGIC P1; REGIONAL BLOOD FLOW;

EID: 0032941838     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199905000-00005     Document Type: Article

References (29)

1. Pelleg A, Porter S. The pharmacology of adenosine. Pharmacotherapy 1990;10:157-74.
2. Stone T. Receptors for adenosine and adenine nucleotides. Gen Pharmacol 1991;22:25-31.
3. Zhou QY, Li C, Olah M, Johnson RA, Stiles GL, Civelli O. Molecular cloning and characterization of an adenosine receptor: the adenosine A3 receptor. Proc Natl Acad Sci USA 1992;89:7432-6.
4. ATP channels, and ischemic preconditioning in dogs. Am J Physiol 1993; 264:H1327-36.
5. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-36.
6. Downey JM. Ischemic preconditioning: Nature's own cardioprotective intervention. Trends Cardiovasc Med 1992;2:170-6.
7. 1 receptor mediated protection of the ischemic rat heart. J Mol Cell Cardiol 1993;25:815-23.
8. Ely SW, Mentzer R, Lasley R, Lee B, Berne R. Functional and metabolic evidence of enhanced myocardial tolerance to ischemia and reperfusion with adenosine. J Thorac Cardiovasc Surg 1985; 90:549-56.
9. 1-selective adenosine analogs protects the heart against infarction. Circulation 1992;85:659-65.
10. 2-receptor agonists on myocardial reperfusion injury. Am Heart J 1992;123:332-8.
11. 1 receptor system. Cardiovasc Res 1993; 27:28-35.
12. Li G, Vasquez J, Gallagher KP, Lucchesi BR. Myocardial protection with preconditioning. Circulation 1990;82:609-19.
13. 2-receptor activation at reperfusion reduces infarct size and improves myocardial wall function in dog heart. J Cardiovasc Pharmacol 1993;22:89-96.
14. 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence. J Pharmacol Exp Ther 1997;280:301-9.
15. 2 adenosine receptor agonist and cardioprotective. FASEB J 1998;12:A78.
16. 2 receptor agonist, AMP 579, in a porcine model of myocardial infarction. J Pharmacol Exp Ther 1998;286:611-8.
17. Patterson RE, Kirk ES. Coronary steal mechanisms in dogs with one-vessel occlusion and other arteries normal. Circulation 1983; 67:1009-15.
18. 1 adenosine receptors in rabbit heart. Circulation 1991; 84:350-6.
19. Schott R, Rohmann S, Braun E, Schaper W. Ischemic preconditioning reduces infarct size in swine myocardium. Circ Res 1990; 66:1133-42.
20. 1-receptors. Circulation 1992;86:1310-6.
21. Liu G, Downey J. Ischemic preconditioning protects against infarction in rat heart. Am J Physiol 1992;263:H1107-12.
22. Li Y, Kloner R. The cardioprotective effects of ischemic preconditioning are not mediated by adenosine receptors in rat hearts. Circulation 1993;87:1642-8.
23. Gross GJ, Auchampach J. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992;70:223-33.
24. Kitakaze M, Hori M, Morioka, et al. Ischemic preconditioning increases adenosine release and 5′-nucleotidase activity during myocardial ischemia and reperfusion in dogs. Circulation 1994; 89:1237-46.
25. 1 receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischemia. Cardiovasc Res 1994;28:270-9.
26. ATP channel. Am J Physiol 1994;266:H829-39.
27. Gross GJ, Warltier DC. Coronary steal in four models of single or multiple vessel obstruction in dogs. Am J Cardiol 1981;48:84-92.
28. Warltier D, Gross G, Brooks H. Coronary steal induced increase in myocardial infarct size after pharmacologic coronary dilation. Am J Cardiol 1980;46:83-90.
29. Gallagher KP, Folts JD, Shebuski RJ, Rankin JH, Rowe GG. Subepicardial vasodilator reserve in the presence of critical coronary stenosis in dogs. Am J Cardiol 1980;46:67-73.