Prognostic significance of loss of heterozygosity at loci on chromosome 17p13.3-ter in sporadic breast cancer is evidence for a putative tumour suppressor gene

British Journal of Cancer

Volumn 80, Issue 5-6, 1999, Pages 821-826

  Liscia, D S ^a   Morizio, R ^a   Venesio, T ^a   Palenzona, C ^a   Donadio, M ^a   Callahan, R ^b  

^a Dipartimento Oncologico ASL 1   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Breast cancer; Chromosome 17p13.3; LOH; Survival

Indexed keywords

ARTICLE; BREAST CANCER; CHROMOSOME 17P; FEMALE; FOLLOW UP; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; TUMOR SUPPRESSOR GENE;

EID: 0032941268     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690427     Document Type: Article

References (28)

1. Bonadonna G, Valagussa P, Tancini G, Rossi A, Brambilla C, Zambetti M, Bignami P, Di Fronzo G and Silvestrini R (1986) Current status of Milan adjuvant chemotherapy trials for node-positive and node-negative breast cancer. Natl Cancer Inst Monogr 1: 45-49
2. Carrozzo R and Ledbetter DH (1993) Dinucleotide repeat polymorphism mapping to the critical region for lissencephaly (17p 13.3). Hum Mol Genet 2: 615
3. Coles C, Thompson AM, Elder PA, Cohen BB, Mackenzie IM, Cranston G, Chetty U, Mackay J, Macdonald M, Nakamura Y, Hoyheim B and Steel CM (1990) Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis. Lancet 336: 761-763
4. Cox DR (1972) Regression models and life tables. J R Stat Soc 34: 187-220
5. Gudmundsson J, Johannesdottir G, Bergthorsson JT, Arason A, Ingvarsson S, Egilsson V and Barkardottir RB (1995) Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13. Cancer Res 55: 4830-4832
6. Heisterkamp N, Kaartinen V, van Soest S, Bokoch GM and Groffen J (1993) Human ABR encodes a protein with GAP-rac activity and homology to the DBL nucleotide exchange factor domain. J Biol Chem 268: 16903-16906
7. Isomura M, Tanigami A, Saito H, Harada Y, Katagiri T, Inazawa J, Ledbetter DH and Nakamura Y (1994) Detailed analysis of LOH on chromosome band 17p13 in breast carcinoma on the basis of a high-resolution physical map with 29 markers. Genes Chromosomes Cancer 9: 173-179
8. Knudson AG (1985), Hereditary cancer, oncogenes and antioncogenes. Cancer Res 45: 1437-1443
9. Lancaster JM, Wooster R, Mangion J, Phelan CM, Cochran C, Gumbs C, Seal S, Barfoot R, Collins N, Bignell G, Patel S, Hamoudi R, Larsson C, Wiseman RW, Berchuck A, Iglehart JD, Marks JR, Ashworth A, Stratton MR and Futreal PA (1996) BRCA2 mutations in primary breast and ovarian cancers. Nat Genet 13: 238-240
10. Lindblom A, Skoog L, Andersen TI, Rotstein S, Nordenskjold M and Larsson C (1993) Four separate regions on chromosome 17 show loss of heterozygosity in familial breast carcinomas. Hum Genet 91: 6-12
11. Mackay J, Steel CM, Elder PA, Forrest AP and Evans HJ (1988) Allele loss on short arm of chromosome 17 in breast cancers. Lancet ii: 1384-1385
12. Makos M, Biel MA, Deiry WE, Nelkin BD, Issa JP, Cavenee WK, Kuerbitz SJ and Baylin SB (1995) p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nature Med 1: 570-577
13. Merlo GR, Venesio T, Bernardi A, Cropp CS, Diella F, Cappa APM, Callahan R, and Liscia DS (1994) Evidence for a second tumour suppressor gene on chromosome 17p linked to high S-phase index in primary human breast carcinomas. Cancer Genet Cytogenet 76: 106-111
14. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballahio A and Carrozzo R (1997) Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E Box and acts as a transcriptional repressor. EMBO J 16: 2892-2906
15. Milner J and Medcalf EA (1991) Cotranslation of activated mutant p53 with wild type drives the wild type p53 protein into the mutant conformation. Cell 65: 765-774
16. Mittra I and MacRae KD (1991) A meta analysis of reported correlations between prognostic factors in breast cancer: does axillary lymph node metastasis represent biology or chronology? Eur J Cancer 27: 1574-1583
17. Morris C, Benjes S, Haataja L, Ledbetter DH, Heisterkamp N and Groffen J (1995) Spatial organization of ABR and CRK genes on human chromosome band 17p13.3. Oncogene 10: 1009-1011
18. Nagai MA, Pacheco MM, Brentani MM, Marques LA, Brentani RR, Ponder BA and Mulligan LM (1994) Allelic loss on distal chromosomes 17p is associated with poor prognosis in a group of Brazilian breast-cancer patients. Br J Cancer 69: 754-758
19. Nakamura Y, Ballard L, Leppert M, O'Connel P, Lathrop GM, Lalouel JM and White R (1988) Isolation and mapping of a polymorphic DNA sequence (pYNZ22) on chromosome 17p [D17S30]. Nucleic Acids Res 16: 570
20. Neuhausen SL and Marshall CJ (1994) Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res 54: 6069-6072
21. Radford DM, Fair KL, Phillips NJ, Ritter JH, Steinbrueck T, Holt MS and Donis-Keller H (1995) Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q. Cancer Res 55: 3399-3405
22. Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G and Nakamura Y (1990) Allelotype of breast cancer: cumulative allele losses promote tumour progression in primary breast cancer. Cancer Res 50: 7184-7189
23. Schultz DC, Vanderveer L, Berman DB, Hamilton TC, Wong AJ and Godwin AK (1996) Identification of two candidate tumor suppressor genes on chromosome 17p13.3. Cancer Res 56: 1997-2002
24. Sidransky D, Takashi T, Helzlsouer K, Zehnbauer B, Rausch G, Shelton B, Prestigiacomo L, Vogelstein B and Davidson N (1992) Inherited p53 gene mutations in breast cancer. Cancer Res 52: 2984-2986
25. Sjögren S, Inganas M, Norberg T, Lindgren A, Nordgren H, Holmberg L and Bergh J (1996) The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 88: 173-182
26. Stack M, Jones D, White G, Liscia DS, Venesio T, Casey G, Crichton D, Varley J, Mitchell E, Heighway J and Santibanez-Koref M (1995) Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17. Hum Mol Genet 4: 2047-2055
27. Theile M, Hartmann S, Scherthan H, Arnold W, Deppert W, Frege R, Glaab F, Haensch W and Scherneck S (1995) Suppression of tumorigenicity of breast cancer cells by transfer of human chromosome 17 does not require transferred BRCA1 and p53 genes. Oncogene 10: 439-447
28. White GRM, Stack M, Santibanez-Koref M, Liscia DS, Venesio T, Wang JC, Helms C, Donis Keller H, Betticher DC, Altermatt HJ, Hoban PR and Heighway J (1996) High levels of loss at the 17p telomere suggest the close proximity of a tumour suppressor. J Cancer 74: 863-870