Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 2, 1999, Pages 177-181

  Kawasaki, Nobuhide ^a   Miyataka, Hideki ^a   Nishiki, Mayumi ^a   Matsumoto, Hitoshi ^a   Inagaki, Naoki ^b   Nagai, Hiroichi ^b   Satoh, Toshio ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

4 4 4 (diphenylmethyl)1 piperazinyl butoxy 2,3,6 trimethylphenol; 5 lipoxygenase; Anti allergic agent; Anti oxidative action; Passive cutaneous anaphylaxis

Indexed keywords

4 [4 [4 (DIPHENYLMETHYL) 1 PIPERAZINYL]BUTOXY] 2,3,6 TRIMETHYLPHENOL; ADENOSINE DIPHOSPHATE; ANTIALLERGIC AGENT; ANTIOXIDANT; FERRIC ION; LIPOXYGENASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHYLHYDROQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; LEUKEMIA CELL; LIPID PEROXIDATION; LIVER MICROSOME; MAST CELL LEUKEMIA; NONHUMAN; ORAL DRUG ADMINISTRATION; PASSIVE SKIN ANAPHYLAXIS; RAT;

EID: 0032941001     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.177     Document Type: Article

References (17)

1. a) Obata T., Okada Y., Motoishi M., Nakagawa N., Terawaki T., Aishita H., Jpn. J. Pharmacol., 60, 227-237 (1992);
2. b) Nakagawa N., Obata T., Kobayashi T., Okada Y., Nambu F., Terawaki T., Aishita H., ibid., 60, 217-225 (1992).
3. Palmblad J., Malmsten C. L., Uden A. M., Radmark O., Engstedt L., Samuelsson B., Blood, 58, 658-661 (1981).
4. a) Naito Y., Sugiura M., Yamaura Y., Fukaya C., Yokoyama K., Nakagawa Y., Ikeda T., Senda M., Fujita T., Chem. Pharm. Bull., 39, 1736-1745 (1991);
5. b) Kiuchi F., Iwakami S., Shibuya M., Hanaoka F., Sankawa U., Chem. Pharm. Bull., 40, 387-391 (1992);
6. c) Satoh Y., Taketomo T., Yokota I., Yoshama Y., Japan Kokai Tokkyo Koho JP06116207 (1994) [Chem. Abstr., 121, 170545 (1994)];
7. d) Tokuda M., Kawabe N., Togami Y., Ishizuka C., Yu A., Ko T., Japan Kokai Tokkyo Koho JP09157206 (1997) [Chem. Abstr., 127, 33971 (1997)].
8. Lundström K., Tenhunen J., Tilgmann C., Karhunen T., Panula P., Ulmanen I., Biochim. Biophys. Acta, 1251, 1-10 (1995).
9. Gubert S., Braso M. A., Sacristan A., Ortiz J. A., Arzneim.-Forsch., 37, 1103-1107 (1987).
10. Taniguchi K., Japan Kokai Tokkyo Koho JP60215643 (1985) [Chem. Abstr., 104, 109228 (1986)].
11. Burn A. J., Cadogan J. I. G., J. Chem. Soc., 1963, 5788-5796.
12. a) Miyachi Y., Pharma Medica, 11, 193-197 (1991);
13. b) Yoshikuni H., Jpn. J. Clin. Immun., 14, 166-173 (1991).
14. Nihro Y., Furukawa H., Sogawa S., Wang T. C., Miyataka H., Matsumoto H., Miki T., Satoh T., Chem. Pharm. Bull., 42, 576-579 (1994).
15. Ohmori K., Ishii H., Nito M., Shuto K., Nakamizo N., Folia Pharmacol. Japon., 81, 399-409 (1983).
16. Sogawa S., Nihro Y., Ueda H., Izumi A., Miki T., Matsumoto H., Satoh T., J. Med. Chem., 36, 3904-3909 (1993).
17. Koda A., Miura T., Inagaki N., Sakamoto O., Arimura A., Nagai H., Mori H., Int. Arch. Allergy Appl. Immunol., 92, 209-216 (1990).