The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 4, 1999, Pages 856-861

  Bottrel, Renata L A ^a,f   Yang, Yi Li ^b   Levy, David E ^c   Tomai, Mark ^d   Reis, Luiz F L ^a,e  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d 3M COMPANY   (United States)

^e LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

^f ICB   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

IMIQUIMOD; INTERFERON; INTERFERON RECEPTOR; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 6; S 26463; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONDYLOMA; DRUG EFFECT; DRUG MECHANISM; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0032940372     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.4.856     Document Type: Article

References (48)

1. Abreu, S. L., F. C. Bancroft, and W. E. Stewart. 1979. Interferon priming. Effects on interferon messenger RNA. J. Biol. Chem. 254:4114-4118.
2. Baker, G. E., and S. K. Tyring. 1997. Therapeutic approaches to papillomavirus infections. Dermatol. Clin. 15:331-340.
3. Beutner, K. R., and A. Ferenczy. 1997. Therapeutic approaches to genital warts. Am. J. Med. 102:28-37.
4. Bohni, R., S. Hemmi, and M. Aguet. 1994. Signaling steps involving the cytoplasmic domain of the interferon-gamma receptor alpha-subunit are not species-specific. J. Biol. Chem. 269:14541-14545.
5. Briken, V., H. Ruffner, U. Schultz, A. Schwarz, L. F. L. Reis, I. Strehlow, T. Decker, and P. Staeheli. 1995. Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon. Mol. Cell. Biol. 15:975-982.
6. Chiu, C. P., C. Moulds, R. L. Coffman, D. Rennick, and F. Lee. 1988. Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc. Natl. Acad. Sci. USA 85:7099-7103.
7. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
8. Dendorfer, U., P. Oettgen, and T. A. Libermann. 1994. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins. cyclic AMP, and lipopolysaccharide. Mol. Cell. Biol. 14:4443-4454.
9. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443-450.
10. Fort, P., L. Marty, M. Piechaczyk, S. el Sabrouty, C. Dani, P. Jeanteur, and J. M. Blanchard. 1985. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenie family. Nucleic Acids Res. 13:1431-1442.
11. Fujita, T., L. F. L. Reis, N. Watanabe, Y. Kimura, T. Taniguchi, and J. Vilcek. 1989. Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways. Proc. Natl. Acad. Sci. USA 86:9936-9940.
12. Grange, J. M., J. L. Stanford, and G. A. Rook. 1995. Tuberculosis and cancer: parallels in host responses and therapeutic approaches? Lancet 345: 1350-1352.
13. Haque, S. J., and B. R. Williams. 1994. Identification and characterization of an Interferon (IFN)-stimulated response element-IFN-stitnulated gene factor 3-independent signaling pathway for IFN-alpha. J. Biol. Chem. 269: 19523-19529.
14. Harrison, C. J., R. L. Miller, and D. I. Bernstein. 1994. Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Antimicrob. Agents Chemother. 38:2059-2064.
15. Harroch, S., M. Revel, and J. Chebath. 1994. Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response clement pIRE and cell type-dependent control of IRF-1 binding to DNA. EMBO J. 13:1942-1949.
16. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-gamma receptor [see comments]. Science 259:1742-1745.
17. Kamijo, R., H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S. I. Koh, T. Kimura, and S. J. Green. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263:1612-1615.
18. Kamijo, R., D. Shapiro, J. Le, S. Huang, M. Aguet, and J. Vilcek. 1993. Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor. Proc. Natl. Acad. Sci. USA 90:6626-6630.
19. Kessler, D. S., D. E. Levy, and J. E. J. Darnell. 1988. Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulaled genes. Proc. Natl. Acad. Sci. USA 85:8521-8525.
20. Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, and T. W. Mak. 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264:1921-1924.
21. Kishimoto, T., S. Akira, and T. Taga. 1992. IL-6 receptor and mechanism of signal transduction. Int. J. Immunopharmacol. 14:431-438.
22. Kohase, M., D. Henriksen-Destefano, L. T. May, J. Vilcek, and P. B. Sehgal. 1986. Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell 45:659-666.
23. Megyeri, K., W. C. Au, I. Rosztoczy, N. B. Raj, R. L. Miller, M. A. Tomai, and P. M. Pitha. 1995. Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways. Mol. Cell. Biol. 15:2207-2218. (Erratum, 15:2905.)
24. Miyamoto, M., T. Fujita, Y. Kimura, M. Maruyama, H. Harada, Y. Sudo, T. Miyata, and T. Taniguchi. 1988. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 54:903-913.
25. Mueller, U., L. F. L. Reis, and M. Aguet. Unpublished data.
26. Mueller, U., U. Steinhoff, L. F. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
27. Ozmen, L., M. Aguet, G. Trinchieri, and G. Garotta. 1995. The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon. J. Virol. 69:8147-8150.
28. Reis, L. F. L., H. Harada, J. D. Wolchok, T. Taniguchi, and J. Vilcek. 1992. Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. EMBO J. 11:185-193.
29. Reis, L. F. L., T. H. Lee, L. T. Ho, and J. Vilcek. 1989. Tumor necrosis factor acts synergistically with autocrine interferon-beta and increases interferon-beta mRNA levels in human fibroblasts. J. Biol. Chem. 264:16351-16354.
30. Reis, L. F. L., H. Ruffner, G. Stark, M. Aguet, and C. Weissmann. 1994. Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J. 13:4798-4806.
31. Rezende, S. A., V. R. Oliveira, A. M. Silva, J. B. Alves, A. M. Gocs, and L. F. L., Reis. 1997. Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection. Infect. Immun. 65:3457-3461.
32. Rutherford, M. N., A. Kumar, A. Nissim, J. Chebath, and B. R. Williams. 1991. The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res. 19:1917-1924.
33. Sailer, A., K. Nagata, D. Naf, M. Aebi, and C. Weissmann. 1992. Interferon regulatory factor-1 (IRF-1) activates the synthetic IRF-1-responsive sequence (GAAAGT)4 in Saccharomyces cerevisiae. Gene Expr. 2:329-337.
34. Savage, P., V. Horton, J. Moore, M. Owens, P. Witt, and M. E. Gore. 1996. A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily. Br. J. Cancer 74:1482-1486.
35. Schijns, V. E., B. L. Haagmans, and M. C. Horzinek. 1995. IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice. J. Immunol. 155:2525-2532.
36. Schindler, C., K. Shuai, V. R. Prezioso, and J. E. J. Darnell. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor [see comments]. Science 257:809-813.
37. Sen, G. C., and P. Lengyel. 1992. The interferon system. A bird's eye view of its biochemistry. J. Biol. Chem. 267:5017-5020.
38. Shuai, K., G. R. Stark, I. M. Kerr, and J. E. J. Darnell. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma [see comments]. Science 261:1744-1746.
39. Sims, S. H., Y. Cha, M. F. Romine, P. Q. Gao, K. Gottlieb, and A. B. Deisseroth. 1993. A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter. Mol. Cell. Biol. 13:690-702.
40. Stark, G. R., and I. M. Kerr. 1992. Interferon-dependent signaling pathways: DNA elements, transcription factors, mutations, and effects of viral proteins. J. Interferon Res. 12:147-151.
41. Swihart, K., U. Fruth, N. Messmer, K. Hug, R. Behin, S. Huang, G. Del Giudice, M. Aguet, and J. A. Louis. 1995. Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J. Exp. Med. 181:961-971.
42. Tomai, M. Unpublished data.
43. Tsuji, M., Y. Miyabira, R. S. Nussenzweig, M. Aguet, M. Reichel, and F. Zavala. 1995. Development of antimalaria immunity in mice lacking IFN-gamma receptor. J. Immunol. 154:5338-5344.
44. Vilcek, J., M. Aguet, and L. F. L. Reis. 1998. Knockouts of interferons. Interferon receptors and interferon signaling components, p. 207-225. In S. K. Durum and K. Muegge (ed.). Contemporary immunology: cytokine knockouts. Humana Press Inc., Totowa, N.J.
45. Vilcek, J., and G. Sen. 1996. IFNs and other cytokines, p. 375-399. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Virology. Lippincott-Raven, Philadelphia, Pa.
46. Wang, Z. E., S. L. Reiner, S. Zheng, D. K. Dalton, and R. M. Locksley, 1994. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.
47. Yang, Y. L., L. F. L. Reis, J. Pavlovic, A. Aguzzi, R. Schafer, A. Kumar, B. R. Williams, M. Aguet, and C. Weissmann. 1995. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14: 6095-6106.
48. Yang, Y. L., and C. Weissmann. 1997. Induction of type 1 interferon by virus or double-stranded RNA is defective in mice devoid of type 1 IFN receptor. J. Interferon Cytokine Res. 17(Suppl. 2):S52. (Abstract.)