Effects of magnesium dobesilate on nitric oxide synthase activity in endothelial cells

International Journal of Angiology

Volumn 8, Issue SUPPL. 1, 1999, Pages

  Suschek, Christoph V ^a   Kolb, Hubert ^a   Kolb Bachofen, Victoria ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDROXYBENZENESULFONIC ACID; MAGNESIUM DOBESILATE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL PROTECTION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

EID: 0032940160     PISSN: 10611711     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf01619845     Document Type: Article

References (23)

1. Suschek C, Rothe H, Fehsel K, Enczmann J, Kolb-Bachofen V (1993) Induction of a macrophage-like nitric oxide synthase in cultuerd rat aortic endothelial cells. J Immunol 151:3283-3291.
2. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012.
3. Kröncke K-D, Fehsel K, Kolb-Bachofen V (1995) Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol Chem 376:327-343.
4. Keen H, Jarret HJ (1979) The WHO multinational study of vascular disease in diabetes. Diabetes care 2:187-195.
5. Bierman EL, Brunzell JD (1978) Interelation of atherosclerosis, abnormal lipid metabolism and diabetes mellitus. In: Advances in Modern Nutrition, Katzen HM, Mahler RJ (eds). Hemisphere Publishing, Washington, London, pp 187-210.
6. Pugliese G, Tilton RG, Williamson JR (1991) Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease. Diabetes Metab Rev 7:35-59.
7. Pugliese G, Tilton TG, Speedy A, et al (1989) Effects of very mild versus overt diabetes on vascular haemodynamics and barrier function in rats. Diabetologia 32:845-857.
8. Arbogast BW, Berry DL, Newell CL (1984) Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats. Atherosclerosis 51:31-45.
9. McVeigh GE, Brennan GM, Johnston GD (1992) Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulitis-dependent) diabetes millitus. Diabetologia 35:771-776.
10. Takahashi K, Ghatei MA, Lam H-C, O'Halloran DJ, Bloom SR (1990) Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia 33:306-310.
11. Bayer J, Meissner KO, Happ J, Cordes U (1980) Calcium dobesilate reduces microvascular permeability to plasma proteins in diabetes mellitus. Dtsch Med Wochenschr 46:1604-1608.
12. Benarroch IS, Brodsky M, Rubinstein A, Viggiano C, Salama EA (1985) Treatment of blood hyperviscosity with calcium dobesilate in patients with diabetic retinopathy. Ophthalmic Res 17:131-138.
13. Heidrich H, Gerke E, Nekarda H (1983) Inhibition of platelet aggregation under calcium dobesilate. Arzneimittelforsch/Drug Res 33:580-582.
14. Michal M, Giessinger N (1985) Effect of calcium dobesilate and its interaction with aspirin on thrombus formation in vivo. Thromb Res 40:215-226.
15. McGuire PG, Orkin RW (1987) Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrates. Lab Invest 57:94-104.
16. Boyde TCR, Rahmatullah M (1980) Optimization of conditions for the colorimetric determination of citrulline, using diacetyl monoxime. Anal Biochem 107:424-431.
17. Suschek C, Fehsel K, Kröncke K-D, Sommer A, Kolb-Bachofen V (1994) Primary cultures of rat capillary endothelial cells: Constitutive and cytokine-inducible macrophage-like nitric oxide synthases are expressed and activities regulated by glucose concentration. Am J Pathol 145:685-695.
18. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142.
19. Langrehr JM, Huffman RA, Lancester JR Jr, Simmons RL (1993) Nitric oxide. A new endogenous immunomodulator. Transplantation 55:1205-1212.
20. Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR (1990) Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochem Biophys Res Commun 167:1037-1043.
21. Baydoun AR, Emery PW, Pearson JD, Mann MG (1990) Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells. Biochem Biphys Res Commun 173:940-948.
22. Hecker M, Sessa WC, Harris HJ, Änggard EE, Vane JR (1990) The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci USA 87:8612-8616.
23. Mitchell JA, Hecker M, Änggard EE, Vane JR (1990) Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF. Eur J Pharmacol 182:573-576.