Inhibition by baclofen of NMDA-activated current in rat dorsal root ganglion neurons

Acta Pharmacologica Sinica

Volumn 20, Issue 4, 1999, Pages 324-328

  Si, Jun Qiang ^a,b   Li, Zhi Wang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shihezi Medical College   (China)

Author keywords

Baclofen; N methyl D aspartate receptors; Patch clamp techniques; Saclofen; Spinal ganglia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SACLOFEN;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL ISOLATION; DRUG INHIBITION; FEMALE; MALE; MEMBRANE CURRENT; NONHUMAN; PATCH CLAMP; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ANIMALS; BACLOFEN; CELL SEPARATION; ELECTROPHYSIOLOGY; FEMALE; GABA AGONISTS; GANGLIA, SPINAL; MALE; N-METHYLASPARTATE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032939290     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. B receptors on A and C primary afferents. Br J Pharmacol 1981; 81: 327-33.
2. B receptors on the somatic membrane of toad dorsal root ganglion neurons. Acta Physiol Sin 1993; 45: 117-23.
3. B receptors in DRG neurons. Acta Physiol Sin 1994; 46: 441-50.
4. Lovinger DM, Weight FF. Glutamate induces a depolarization of adultrat dosal root ganglion neurons that is mediated predominantly by NMDA receptors. Neurosci Lett 1988; 94: 314-20.
5. Sato K, Kiyama H, Park HT, Tohyama M. AMPA, KA, and NMDA receptors are expressed in the rat DRG neurones. Neuroreport 1993; 4: 1263-5.
6. Liu H, Wang H, Sheng M, Jan YN, Basbaum AI. Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc Natl Acad Sci USA 1994; 91: 8383-7.
7. Si JQ, Hu HZ, Wu XP, Fan YZ, Liu CI, Li ZW. A new method combining electrophysiological identification of membrane receptors with immunohistochemical detection of intracellular neurotransmitters in the same isolated rat DRG neuron. Chin J Appl Physiol 1996; 12: 77-81.
8. Si JQ, Li ZW, Fan YZ. Modulatory effect of SP on GABA- and NMDA-activated currents in neurons freshly isolated from rat DRG. Chin J Neurosci 1996; 3: 114-9.
9. Si JQ, Li ZW, Hu HZ, Zhou XP, Guan BC. Inhibitory effect of baclofen on GABA-induced depolarization and GABA-activated current in primary sensory neurons. Neuroscience 1997; 81: 821-7.
10. Morrisett RA, Mott DD, Lewis DV, Swartzwelder HS, Wilson WA. GABA-receptor-mediated inhibition of N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. J Neurosci 1991; 11: 203-9.
11. Barber RP, Vaughn JF, Saito K, Melaughlin BJ. GABAergic terminals are pre-synaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord. Brain Res 1978; 141: 35-55.
12. Dolphin AC, Scott RH. Calcium channel currents and their inhibition by (-)-baclofen rat sensory neurones: modulation by guanine nucleotides. J Physiol (Lond) 1987; 386: 1-17.
13. o: antisenseoligonucleotide studies. J Physiol (Lond) 1993; 470: 1-11.
14. Mayer ML, Westbrook GL. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol 1987; 28: 197-276.