An approach to area sampling and analysis for total isocyanates in workplace air

American Industrial Hygiene Association Journal

Volumn 60, Issue 2, 1999, Pages 200-207

  Key Schwartz, Rosa J ^a   Tucker, Samuel P ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Isocyanates; Sampling and analysis

Indexed keywords

1 (2 METHOXYPHENYL)PIPERAZINE; ACETONITRILE; DIMETHYL SULFOXIDE; HEXAMETHYLENE DIISOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; MONOMER; OLIGOMER; TOLUENE; TOLUENE DIISOCYANATE; TRYPTAMINE; UREA DERIVATIVE;

AEROSOL; AIR ANALYSIS; AIR SAMPLING; ANALYTIC METHOD; ARTICLE; CALIBRATION; ELECTROCHEMICAL DETECTION; ENVIRONMENTAL TEMPERATURE; FLUORESCENCE ANALYSIS; HUMIDITY; OCCUPATIONAL HEALTH SERVICE; POLYMERIZATION; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTRAL SENSITIVITY; TITRIMETRY; WORKPLACE; WORKROOM AIR;

EID: 0032939101     PISSN: 00028894     EISSN: None     Source Type: Journal    
DOI: 10.1080/00028899908984436     Document Type: Article

References (48)

1. Hardy, H.L., and J.M. Devine: Use of organic isocyanates in industry - some industrial hygiene aspects. Ann. Occup. Hyg. 22:421-427 (1979).
2. Silk, S.J., and H.L. Hardy: Control limits for isocyanates. Ann. Occup. Hyg. 27:333-379 (1983).
3. Cockcroft, D.W., and J.T. Mink: Isocyanate-induced asthma in an automobile spray painter. Can. Med. Assoc. J. 121:602-604 (1979).
4. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Refort: Trans World Airlines Main Overhaul Facility, Kansas City International Airfort, Kansas City, MO (Report No. HHE 72-96-0237, NTIS No. PB249417). Cincinnati, OH: NIOSH, 1975.
5. Tornling, G., R. Alexandersson, G. Hedenstierna, and N. Plato: Decreased lung function and exposure to diisocyanates (HDI and HDI-BT) in car repair painters: observations on re-examination 6 years after initial study. Am. J. Ind. Med. 17:299-310 (1990).
6. Belin, L., U. Hjortsberg, and U. Wass: Life threatening pulmonary reaction to car paint containing prepolymerized isocyanate. Scand. J. Work Environ. Health 7:310-311 (1981).
7. Nielsen, J., C. Sango, G. Winroth, T. Hallberg, and S. Skerfving: Systemic reactions associated with polyisocyanate exposure. Scand. J. Work Environ. Health 11:51-54 (1985).
8. Rando, R.J., H. Abdel-Kader, J. Hughes, and Y.Y. Hammad: Toluene diisocyanates exposures in the flexible polyurethane foam industry. Am. Ind. Hyg. Assoc. J. 45:580-585 (1987).
9. Lesage, J., N. Goyer, F. Desjardins, J. Vincent, and G. Perrault: Workers' exposure to isocyanates. Am. Ind. Hyg. Assoc. J. 53:146-153 (1992).
10. Vandenplas, O., A. Cartier, J. Lesage, G. Perrault, L.C. Grammer, and J. Malo: Occupational asthma caused by a prepolymer but not the monomer of toluene diisocyanate (TDI). J. Allergy Clin. Immunol. 89:1183-1188 (1992).
11. Janko, M., K. McCarthy, M. Fajer, and J. van Raalte: Occupational exposure to 1,6-hexamethylene diioscyanate-based polyisocyanates in the state of Oregon, 1980-1990. Am. Ind. Hyg. Assoc. J. 53:331-338 (1992).
12. Purnell, C.J., and R.F. Walker: Methods for the determination of atmospheric isocyanates. Anal. Proc. 18:472-478 (1981).
13. Levine S.P., K.J.D. Hillig, V. Dharmarajan, M.W. Spence, and M.D. Baker: Critical review of methods of sampling, analysis, and monitoring for TDI and MDI. Am. Ind. Hyg. Assoc. J. 56:581-589 (1995).
14. Bayer: Methods for Sampling and Analysis of Airborne Isocyanates. Pittsburgh, PA: Bayer, 1992.
15. ICI Polyurethanes Group, Industrial Hygiene Laboratory: Method I1024-G. Rev. 1.9. Method for the Collection, Storage and Determination of Airborne 4,4′-Methylenediphenylisocyanate (MDI) and Phenylisocyannte (PI) Vapor and Participates. West Deptford, NJ: ICI Polyurethanes Group, 1996.
16. Rando, R.J., and H.G. Poovey: Dichotomous sampling of vapor and aerosol of methylene-bis-(phenylisocyanate) [MDI] with an annular diffusional denuder. Am. Ind. Hyg. Assoc. J. 55:716-721 (1994).
17. National Institute for Occupational Safety and Health (NIOSH): Isocyanates: Method 5521. In NIOSH Manual of Analytical Methods (Pub. no. 84-100), 3rd rev. ed., P.M. Eller (ed.). Cincinnati, OH: NIOSH1 1984. (Supplement issued 5/15/89.)
18. Health & Safety Executive: MDHS 25, Methods for the Determination of Hazardous Substances: Organic Isocyanates in Air. London: Health & Safety Executive, 1987.
19. Key-Schwartz, R.J.: Analytical problems in the determination of 1,6-hexamethylene diisocyanate using NIOSH Method 5521. Appl. Occup. Environ. Hyg. 7:643-644 (1992).
20. Key-Schwartz, R.J.: Analytical problems encountered with NIOSH Method 5521 for total isocyanates. Am. Ind. Hyg. Assoc. J. 56:474-479 (1995).
21. Streicher, R.P., J.E. Arnold, C.V. Cooper, and T.J. Fischbach: Investigation of the ability of MDHS Method 25 to determine urethane-bound isocyanate groups. Am. Ind. Hyg. Assoc. J. 56:437-442 (1995).
22. National Institute for Occupational Safety and Health (NIOSH): Isocyanates, monomeric: Method 5521. In NIOSH Manual of Analytical Methods (Pub. no. 94-113), 4th rev. ed., P.M. Eller (ed.). Cincinnati, OH: NIOSH, 1994.
23. Wu, W.S., R.E. Stoyanoff, R.S. Szklar, V.S. Gaind, and M. Rakanovic: Application of tryptamine as a derivatizing agent for airborne isocyanate determination. Part 3. Evaluation of total isocyanates analysis by high-performance liquid chromatography with fluorescence and amperometric detection. Analyst 115:801-807 (1990).
24. American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Values and Biological Exposure Indices for 1997. Cincinnati, OH: ACGIH, 1997.
25. Purnell, C.J., and R.F. Walker: Methods for the determination of atmospheric organic isocyanates a review. Analyst 110:893-905 (1985).
26. Wu, W.S., and V.S. Gaind: Application of tryptamine as a derivatizing agent for the determination of airborne isocyanates. Part 5. Investigation of tryptamine-coated XAD-2 personal sampler for airborne isocyanates in workplaces. Analyst 117:9-12 (1992).
27. National Institute for Occupational Safety and Health (NIOSH): Isocyanates: Method 5522. In NIOSH Manual of Analytical Methods (Pub. no. 96-135; 1st suppl.), 4th rev. ed., P.M. Eller (ed.). Cincinnati, OH: NIOSH, 1996. (Supplement issued 5/15/96).
28. Bayer: Material Safety Sheet: Desmodur N-3300 (Product code D-429). Pittsburgh, PA: Bayer, 1991.
29. Dow Chemical: Material Safety Sheet: PAPI 27 (Product code no. 10-027-61). La Porte, TX: Dow Chemical Co., 1990.
30. Siggia, S., and J.G. Hanna: Determination of organic isocyanates and isothiocyanates. Ind. Eng. Chem., Anal. Ed. 20:1084 (1948).
31. National Institute for Occupational Safety and Health (NIOSH): NIOSH Technical Report: Guidelines for Air Sampling and Analytical Method Development and Evaluation, Appendix 3 - Limits of Detection and Quantitation (Pub. no. 95-117). Cincinnati, OH: NIOSH, 1995.
32. J.T. Baker Chemical Co.: Material Safety Data Sheet: Dimethyl Sulfoxide (Product codes 9194, 9224, 9285; NIOSH/RTECS no. PV6210000). Phillipsburg, NJ: J.T. Baker Chemical Co., 1997.
33. Brayton C.F.: Dimethyl sulfoxide (DMSO): A review. Cornell Vet. 76:61-90 (1986).
34. Knudsen L.E.: Dimethylsulfoxide. Copenhagen: Danish Institute of Occupational Health, 1991.
35. Schwope, A.D., M.A. Randel, and M.G. Broome: Dimethyl sulfoxide permeation through glove materials. Am. Ind. Hyg. Assoc. J. 42: 722-725 (1981).
36. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Virginia Pocobontus Mine Complex, Pittsburgh, PA (Report no. HETA 93-0560). Cincinnati, OH: NIOSH, 1993.
37. Wu, W.S., R.S. Szklar, and V.S. Gaind: Application of tryptamine as a derivatizing agent for airborne isocyanate determination. Part 2. Dual function of tryptamine for calibration and derivatization of poly[methylene(polyphenyl isocyanate)] for quantification by high-performance liquid chromatography. Analyst 113:1209-1212 (1988).
38. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Circular Technologies, Boulder, CO (Report no. HETA 91-094). Cincinnati, OH: NIOSH, 1994.
39. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Martin's Carstar, Inc., Lakewood, CO (Report no. HETA 95-0311-2593, NTIS no. PB97147219.). Cincinnati, OH: NIOSH, 1996.
40. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Spence's Carstar, Inc., Denver, CO (Report no. HETA 95-0405-2600.). Cincinnati, OH: NIOSH, 1996.
41. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Matrix Autobody, Denver, CO (Report no. HETA 95-0406-2609). Cincinnati, OH: NIOSH, 1996.
42. Rudzinski, W.E., L. Pin, T. Thomas, A. Richardson, R. Sutcliffe, and B. Dahlquist: "Evaluation of Diisocyanate Sampling and Analysis in Spray-painting Operations." Poster presented at the American Industrial Hygiene Conference and Exposition, Anaheim, CA, May 1994.
43. Rudzinski, W.E., R. Sutcliffe, B. Dahlquist, and R. Key-Schwartz: Evaluation of tryptamine in an impinger and on XAD-2 for the analysis of hexamethylene-based isocyanates in spray-painting operations. Analyst 122:605-609 (1997).
44. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Whirlpool, Corp., Evansville, IN (Report no. HETA 94-0124-2470, NTIS no. PB95189694.). Cincinnati, OH: NIOSH, 1996.
45. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Unidentified Hot Tub Manufacturer, Denver, CO (Report No. HETA 93-0885). Cincinnati, OH: NIOSH, 1994.
46. National Institute for Occupational Safety and Health (NIOSH): Hazard Evaluation and Technical Assistance Report: Trus Joist Mac-Millan, Deerwood, MN(Report no. HETA 93-0436-2569, NTIS no. B96197405.). Cincinnati, OH: NIOSH, 1996.
47. Key-Schwartz, R.J., S. Shulman, J. Snyder, and R.P. Streicher: Comparison of methods for MDI in spray-foaming operations in a test mine. [Manuscript in preparation.]
48. Mine Safety and Health Administration (MSHA): Investigative Report: Jim Walters Resources, Inc., No. 4 Mine, Brookwood, AL (Report no. MSHA 95-001, PP-008-95C). Pittsburgh, PA: MSHA, 1994.