7-Ethoxycoumarin deethylation activity in perfused isolated rat brain

Journal of Biochemistry

Volumn 125, Issue 3, 1999, Pages 634-640

  Chikaoka, Yoko ^a,b   Tamura, Mamoru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

Cerebral tissue; Cytochrome P 450; Drug metabolizing activity; Microsome; Perfused brain

Indexed keywords

7 ETHOXYCOUMARIN; 7 ETHOXYCOUMARIN DEETHYLASE; BETA NAPHTHOFLAVONE; CYTOCHROME P450; DRUG METABOLIZING ENZYME; PHENOBARBITAL; UMBELLIFERONE;

ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN MICROSOME; DRUG METABOLISM; ENZYME ACTIVITY; INTERNAL CAROTID ARTERY; LIVER PERFUSION; MALE; NONHUMAN; RAT; SUPERIOR CAVA VEIN;

ANIMALIA;

EID: 0032938765     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022330     Document Type: Article

References (34)

1. Guengerich, F.P. (1990) Enzymatic oxidation of xenobiotic chemicals. Biochem. Mol. Biol. 25, 97-153
2. Strobel, H.W., Geng, J., Kawashima, H., and Wang, H. (1997) Cytochrome P450-dependent biotransformation of drugs and other xenobiotic substrates in neural tissue. Drug Metab. Rev. 29, 1079-1105
3. Ravindranath, V., Bhamre, S., Bhagwat, S.V., Anandatheerthavarada, H.K., Shankar S.K., and Tirumalai, P.S. (1995) Xenobiotic metabolism in brain. Toxicol. Lett. 82/83, 633-638
4. Ravindranath, V. and Boyd, M.R. (1995) Xenobiotic metabolism in brain. Drug Metab. Rev. 27, 419-448
5. Minn, A., Ghersi-Egea, J.F., Perrin, R., Leininger B., and Siest, G. (1991) Drug metabolizing enzymes in the brain and cerebral microvessels. Brain Res. Rev. 16, 65-82
6. Lineweber, F.J. (1991) Drug disposition in the mammalian eye and brain: a comparison of mechanisms. Drug Metab. Rev. 23, 133-246
7. Mesnil, M., Testa, B., and Jenner, P. (1984) Xenobiotic metabolism by brain mono-oxygenases and other cerebral enzymes in Advances in Drug Research Vol. 3, pp. 95-207, Academic Press, London
8. Mailman, R.B. (1980) Biochemical toxicology of the central nervous system in Introduction to Biochemical Toxicology (Hodgson, E. and Guthrie, F.E., eds.) pp. 224-244, Blackwell Science Publishers, Oxford
9. Bhagwat, S.V., Boyd, M.R., and Ravindranath, V. (1995) Rat brain cytochrome P450. Reassessment of monooxygenase activities and cytochrome P450 levels. Drug Metab. Dispos. 23, 651-654
10. Anandatheerthavarada, H.K., Shankar, S.K., and Ravindranath, V. (1990) Rat brain cytochromes P-450: catalytic, immunochemical properties and inducibility of multiple forms. Brain Bes. 536, 339-343
11. Warner, M., Köhler, C., Hansson, T., and Gustafsson, J.Å. (1988) Regional distribution of cytochrome P-450 in the rat brain: spectral quantitation and contribution of P-450 b, e and P-450 c, d. J. Neurochem. 50, 1057-1065
12. Näslund, B.M.A., Glaumann, H., Warner, M., Gustafsson, J.-Å., and Hanson, T. (1987) Cytochrome P-450 b and c in the rat brain and pituitary gland. Mol. Phramacol. 33, 31-37
13. Srivastava, S.P., Seth, P.K., and Mukhtar, H. (1983) 7-Ethoxycoumarin O-deethylase activity in rat brain microsomes. Biochem. Pharmacol. 32, 3657-3660
14. Guengerich, F.P. and Mason, P.S. (1978) Immunological comparison of hepatic and extrahepatic cytochromes P-450. Mol. Pharmacol. 15, 154-164
15. Bonate, P.L. (1995) Animal models for studying transport across the blood-brain barrier. J. Neurosci. Methods 56, 1-15
16. Rapoport, S.I., Ohno, K., and Pettigrew, K.D. (1979) Drug entry into the brain. Brain Res. 172, 354-359
17. Benzi, G., Berté, F., Crema, A., and Frigo, G.M. (1967) Cerebral drug metabolism investigated by isolated perfused brain in situ. J. Pharmac, Sci. 56, 1349-1351
18. Inagaki, M. and Tamura, M. (1993) Preparation and optical characteristics of hemoglobin-free isolated perfused rat head in situ. J. Biochem. 113, 650-657
19. Sugano, T., Suda, K., Shimada, M., and Oshino, N. (1978) Biochemical and ultrastructural evaluation of isolated rat liver systems perfused with a hemoglobin-free medium. J. Biochem. 83, 995-1007
20. Ji, S., Lemasters, J.J., and Thurman, R.G. (1981) A fluorometric method to measure sublobular rates of mixed-function oxidation in the hemoglobin-free perfused rat liver. Mol. Pharmacol. 19, 513-516
21. Das, M., Seth, P.K., and Mukhtar, H. (1981) Characterization of microsomal aryl hydrocarbon hydroxylase of rat brain. J. Pharmacol. Exp. Ther. 216, 156-161
22. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
23. Aitio, A. (1978) A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal. Biochem. 85, 488-491
24. Rapoport, S.I., Fredericks, W.R., Ohno, K., and Pettigrew, K.D. (1980) Quantitiative aspects of reversible osmotic opening of the blood-brain barrier. Am. J. Physiol. 238, R421-R431
25. Nomura, Y., Mastunaga, A., and Tamura, M. (1998) Optical characterization of heme a+a3 and copper of cytochrome oxidase in blood-free perfused rat brain. J. Neurosci. Methods 82, 135-144
26. Tamura, M. and Nomura, Y. (1996) Organ perfusion in Method for Biochemical Experiment (Shimonisi, Y., Nagai, K., Hase, S., and Honda, T., eds.) pp. 41-57, Kagakudojin, Kyoto
27. Walther, B., Ghersi-Egea, J.F., Jayyosi, Z., Minn, A., and Siest, G. (1987) Ethoxyresorufin O-deethylase activity in rat brain subcellular fractions. Neurosci. Lett. 76, 58-62
28. Roberts, M.S. and Rowland, M.J. (1986) Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model. J. Pharm. Pharmacol. 38, 177-181
29. Britto, M.R. and Wedlund, P.J. (1992) Cytochrome P-450 in the brain: Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes. Drug. Metab. Dispos. 20, 446-450
30. Häussinger, D. (1983) Hepatocyte heterogeneity in glutamate and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur. J. Biochem. 133, 269-275
31. Conway, J.G., Kauffman, F.C., Tsukuda, T., and Thurman, R.G. (1987) Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the lobule in livers from untreated and 3-methylcholanthrene-treated rats. Mol. Pharmacol. 33, 111-119
32. Turman, R.G. and Kauffman, F.C. (1980) Factors regulating drug metabolism in intact hepatocytes. Pharmacol. Rev. 31, 229-251
33. Iyanagi, T., Suzuki, T., and Kobayashi, S. (1981) Oxidation-reduction states of pyridine nucleotide and cytochrome P-450 during mixed-function oxidation in perfused rat liver. J. Biol. Chem. 256, 12933-12939
34. Kawaji, A., Isobe, M., Tochino, Y., Takabatake, E., Chikaoka, Y., Nomura, Y., and Tamura, M. (1998) Flavin containing monooxygenase mediated metabolism of benzydamine in perfused brain and liver. Biochem. Biophys. Acta 24663, 1-6