Acquired inhibitor against factor IX in a child: Successful treatment with high-dose immunoglobulin and dexamethasone

Haemophilia

Volumn 5, Issue 2, 1999, Pages 132-134

  Mazzucconi, M G ^a,c   Peraino, M ^a   Bizzoni, L ^a   Bernasconi, S ^a   Luciani, M ^b   De Rossi, G ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c Hematology   (Italy)

Author keywords

Acquired coagulation inhibitors; Dexamethasone; High dose Ig; Immunosuppressive therapy; Inhibitors to factor IX:C

Indexed keywords

BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING INHIBITOR; DEXAMETHASONE; IMMUNOGLOBULIN;

ARTICLE; CASE REPORT; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HEMATOMA; HEMOPHILIA B; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PARTIAL THROMBOPLASTIN TIME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTHROMBIN TIME;

CHILD, PRESCHOOL; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FACTOR IX; FEMALE; HEMATOMA; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOSUPPRESSIVE AGENTS; PLASMA EXCHANGE; PREDNISONE; TREATMENT OUTCOME;

EID: 0032938726     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.1999.00297.x     Document Type: Article

References (6)

1. Biggs R. Jaundice and antibodies directed against Factor VIII and IX in patients treated for haemophilia or Christmas disease in the United Kingdom. Br J Haematol 1974; 26: 313-29.
2. Brettler DB. Inhibitor of factor VIII and IX. Haemophilia 1995; 1 (Suppl.1): 35-9.
3. Ozsoylu S, Ozer FL. Acquired factor IX deficiency. A report of two cases. Acta Haematol 1973; 50: 305- 14.
4. Largo R, Sigg P, von Felten A, Straub PW. Acquired Factor IX inhibitor in a non-haemophilic patient with autoimmune disease. Br J Haematol 1974; 26: 129- 40.
5. Siemens HJ, Bruckner S, Katus HA. Acquired inhibitors against factor VIII or IX in non-hemophiliacs undergoing major surgery. Two case reports. XXIIIth International Congress of the World Federation of Hemophilia, The Hague, The Netherlands, 17-21 May 1998, (Abstract no. 388, p. 253).
6. Miller K, Neely JE, Krivi W, Edson JR. Spontaneous acquired factor IX inhibitor in a non-hemophilic child. J Pediatr 1978; 93: 232-4.