Beta-blocker selectivity at cloned human beta1- and beta2-adrenergic receptors

Cardiovascular Drugs and Therapy

Volumn 13, Issue 2, 1999, Pages 123-126

  Smith, Carol ^a   Teitler, Milt ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Beta blocked; Cardioselectivity; Cloned beta receptors; Selectivity

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; BISOPROLOL; CARVEDILOL; METOPROLOL; PROPRANOLOL; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ADRENERGIC BETA-ANTAGONISTS; CELL LINE; CLONING, MOLECULAR; DRUG EVALUATION, PRECLINICAL; HUMANS; LOGISTIC MODELS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0032938071     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007784109255     Document Type: Article

References (22)

1. 1. Cleland JG, Bristow MR, Erdmann E, Remme WJ, Swedberg K, Waagstein F. Beta-blocking agents in heart failure. Should they be used and how? Eur Heart J 1996;17: 1629-1639.
2. 2. Dargie HJ. Angina and left ventricular dysfunction. Eur Heart J 1996;17(Suppl G.):2-7.
3. 3. Doughty RN, Sharpe N. Beta-adrenergic blocking agents in the treatment of congestive heart failure: Mechanisms and clinical results Ann Rev Med 1997;48:103-114.
4. 4. Goldstein S. Beta-blockers in hypertensive and coronary heart disease Arch Intern Med 1996;156:-1276.
5. 5. Goldstein S. Beta-blocking drugs and coronary heart disease Cardiovasc Drugs Ther 1997;11(Suppl. 1)219-225.
6. 6. Hampton JR. Choosing the right beta-blocker. A guide to selection Drugs 1994;48:549-568.
7. 7. Hjalmarson A. Empiric therapy with beta-blockers Pacing Clin Electrophysiol 1994;17:460-466.
8. 8. Caron MG, Lefkowitz RJ. Catecholamine receptors: Structure, function, and regulation. Recent Progr Horm Res 1993;48:277-290.
9. 9. Ostrowski J, Kjelsberg MA, Caron MG, Lefkowitz RJ. Mutagenesis of the beta 2-adrenergic receptor: How structure elucidates function Annu Rev Pharmacol Toxicol 1992;32: 167-183.
10. 10. Roth NS, Lefkowitz RJ, Caron MG. Structure and function of the adrenergic receptor. Adv Expe Med Biol 1991;308: 223-238.
11. 11. Collins S, Lohse MJ, O'Dowd B, Caron MG, Lefkowitz RJ. Structure and regulation of G protein-coupled receptors: The beta 2-adrenergic receptor as a model Vitam Horm 1991;46:1-39.
12. 12. Belvisi M. Beta-blocker induced asthma: A role for sensory nerve hyperresponsiveness Clin Exp Allergy 1996;26: 1343-1346.
13. 13. Wellstein A, Palm D, Belz GG. Affinity and selectivity of beta-adrenoceptor antagonists in vitro. J Cardiovasc Pharmacol 1986;8(Suppl, 11):S36-S40.
14. 14. Hjalmarson A, Waagstein F. The role of beta-blockers in the treatment of cardiomyopathy and ischaemie heart failure Drugs 1994;47(Suppl. 4):31-39.
15. 15. Brodde OE. Bisoprolol (EMD 33512), a highly selective beta 1-adrenoceptor antagonist: In vitro and in vivo studies. J Cardiovas Pharmacol 1986;8(Suppl. 11):S29-S35
16. 16. Wellstein A, Palm D, Belz GG. Affinity and selectivity of beta-adrenoceptor antagonists in vitro. J Cardiovasc Pharmacol 1986;8(Suppl. 11):S36-S40.
17. 17. Minneman KP, Pittman RN, Molinoff PB. Beta-adrenergic receptor subtypes: Properties, distribution, and regulation. Annu Revi Neurosci 1981;4:419-461.
18. 18. Frielle T, Caron MG, Lefkowitz RJ. Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning Clini Chem 1989;35:721-725.
19. 19. Caron MG, Kobilka BK, Frielle T, et al. Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. J Receptor Res 1988;8:7-21.
20. 20. Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci USA 1987;84: 7920-7924.
21. 21. Leonhardt S, Gorospe E, Hoffman BJ, Teitler M. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine 1 C and 5-hydroxytryptamine 2 receptors. Mol Pharmacol 1992;42:328-335.
22. 22. Minnear FL, DeMichele MA, Leonhardt S, Andersen TT, Teitler M. Isoproterenol antagonizes endothelial permeability induced by thrombin and thrombin receptor peptide. J Appl Physiol 1993;75:1171-1179.