Molecular modeling and preclinical evaluation of the humanized NR-LU-13 antibody

Clinical Cancer Research

Volumn 5, Issue 4, 1999, Pages 899-908

  Graves, Scott S ^a   Goshorn, Stephen C ^a   Stone, Diane M ^a   Axworthy, Don B ^a   Reno, John M ^a   Bottino, Becky ^a   Searle, Stephen ^b   Henry, Andrew ^b,c   Pedersen, Jan ^b,d   Rees, Anthony R ^b   Libby, Randell T ^a,e  

^a Poniard Pharmaceuticals Inc   (United States)

^b University of Bath   (United Kingdom)

^c Medawar Centre   (United Kingdom)

^d Receptor Technologies A/S   (Denmark)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; IMMUNOGLOBULIN G2B; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NR LU 10; MONOCLONAL ANTIBODY NR LU 13; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELL STRAIN MCF 7; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; CHO CELLS; CRICETINAE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASMS, EXPERIMENTAL; POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

EID: 0032937699     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Britton, K., and Granowska, M. Radioimmunoscintigraphy in tumor identification. Cancer Surv., 6: 247-267, 1987.
2. Morell, A., Terry, W. D., and Waldman, T. A. Metabolic properties of IgG subclasses in man. J. Clin. Investig., 49: 673-680, 1970.
3. Chatenoud, L., Baudrihaye, M. F., Chkoff, N., Kreis, H., Goldstein, G., and Bach, J-F. Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3. J. Immunol., 137: 830-838, 1986.
4. Khazaeli, M. B., Saleh, M. N., Wheeler, R. H., Huster, W. J., Holden, H., Carranto, R., and LoBuglio, A. F. Phase I trial of multiple large doses of murine monoclonal antibody CO17-1A. II. Pharmacokinetics and immune response. J. Natl. Cancer Inst., 80: 937-942, 1988.
5. Seccamani, E., Tattanelli, M., Mariani, M., Spranzi, E., Scassellati, G. A., and Siccardi, A. G. A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples. Int. J. Radiat. Appl. Instrum., 16: 167-170, 1989.
6. Sahagan, B. G., Dorai, H., Saltzgaber-Muller, J., Toneguzzo, F., Guindon, C. A., Lilly, S. P., McDonald, K. W., Morrissey, D., Stone, B. A., Davis, G. L., McIntosh, P. K., and Moore, G. P. A genetically engineered murine/human chimeric antibody retains specificity for human tumor-associated antigen. J. Immunol., 137: 1066-1074, 1986.
7. Sun, L. K., Curtis, P., Radowicz-Szulczynska, E., Ghrayeb, J., Chang, N., Morrison, S. L., and Kaprowski, H. Chimeric antibody with human constant regions and mouse variable regions directed against carcinoma-associated antigen 17-1A. Proc. Natl. Acad. Sci. USA, 84: 214-218, 1987.
8. Nishimura, Y., Yokoyama, M., Araki, K., Ueda, R., Kudo, A., and Watanabe, T. Recombinant human-mouse chimeric monoclonal-antibody specific for common acute lymphocytic leukemia antigen. Cancer Res., 47: 999-1005, 1987.
9. Liu, A. Y., Robinson, R. R., Hellstrom, K. E., Murray. E. D., Chang, C. P., and Hellstrom, I. Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells. Proc. Natl. Acad. Sci. USA, 84: 3439-3443, 1987.
10. Beidler, C. B., Ludwig, J. R., Cardenas, J., Phelps, J., Papworth, C. G., Melcher, E., Sierzega, M., Myers, L. J., Unger, B. W., Fisher, M., David, G. S., and Johnson, M. J. Cloning and high level expression of a chimeric antibody with specificity for human carcinoembryonic antigen. J. Immunol., 141: 4053-4060, 1988.
11. Varki, N. M., Reisfield, R. A., and Walker, L. E. Antigens associated with a human lung adenocarcinoma defined by monoclonal antibodies. Cancer Res., 11: 638-687, 1984.
12. Helfrich, W., Koning, P. W., The, T. H., and DeLeij, L. Epitope mapping of SCLC-Cluster-2 Mabs and generation of antibodies directed against new EGP-2 epitopes. Int. J. Cancer Suppl., 8: 64-69, 1994.
13. deLeij, L., Helrich, W., Stein, R., and Mattes, M. J. SCLC-Cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2. Int. J. Cancer Suppl., 8: 60-63, 1994.
14. Szala, S., Froehlich, M., Scollon, M., Kasai, Y., Steplewski. Z., Koprowski, H., and Linnenbach, A. Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. Proc. Natl. Acad. Sci. USA, 87: 3542-3546, 1990.
15. Strand, J., Hamilton, A. E., Beavers, L. S., Gamboa, G. C., Apelgren, L. D., Taber, L. D., Sportsman, J. R., Bumol, T. F., Sharp, J. D., and Gadski, R. A. Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA. Cancer Res., 49: 314-317, 1989.
16. Herlyn, M., Steplewski, Z., Herlyn, D., and Koprowski, H. CO 17-1A and related monoclonal antibodies: their production and characterization. Hybridoma, 5: S3-S10, 1986.
17. Spearman, M. E., Goodwin, R. M., Apelgren, L. D., and Bumol, T. F. Disposition of the monoclonal antibody-Vinca alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-desacetylvinblastine in tumor-bearing nude mice. J. Pharmacol. Exp. Ther., 241: 695-703, 1987.
18. Bumol, T. F. Workshop summary: monoclonal antibodies conjugates with drugs or toxins. In: R. A. Reisfield and S. Sell (eds.), Monoclonal Antibodies and Cancer Therapy, pp. 257-259. New York: Alan R. Liss, Inc., 1985.
19. Bumol, T. F., Parrish, J., De Herdt, S. V., Spearman. M. E., Pohland, R., Borowitz, M. J., Briggs, S. L., Baker, A. L., Marder, P., and Apelgren, L. D. Studies on a epithelial/epithelial malignancy associated antigen associated with human adenocarcinomas. In: R. L. Ceriani (ed.). Immunological Approaches to the Diagnosis and Therapy of Breast Cancer, pp. 205-215. New York: Plenum Publishing Corp., 1987.
20. Balaban, E. P., Walker, B. S., Cox, J. V., Bordlee, R. P., Salk, D., Abrams, P. G., Sheehan, R. G., and Frenkel, E. P. Detection and staging of small lung cell carcinoma with a technetium-labeled monoclonal antibody: a comparison with standard staging methods. Clin. Nucl. Med., 17: 439-445, 1992.
21. Breitz, H. B., Weiden, P. L., Vanderheyden, J-L., Appelbaum, J. W., Bjorn, M. J., Fer, M. F., Wolf, S. B., Ratliff, B. A., Seller, C. A., Foisie, D. C., Fisher, D. R., Schroff, R. W., Fritzberg, A. R., and Abrams, P. G. Clinical experience with rhenium-186-labeled monoclonal antibodies for radioimmunotherapy: results of Phase I trials. J. Nucl. Med., 33: 1099-1109, 1992.
22. Schroff, R. W., and Stevenson, H. C. Human immune responses to murine monoclonal antibodies. In: K. A. Foon and A. C. Morgan (eds.), Monoclonal Antibody Therapy of Human Cancer, pp. 121-138. The Hague: Nijhoff, 1985.
23. Saleh, M. N., LoBuglio, A. F., Wheeler, R. H., Rogers, K. J., Haynes, A., Lee, J. Y., and Khazael, M. B. A Phase II trial of murine monoclonal antibody 17-1A and interferon-γ: clinical and immunological data. Cancer Immunol. Immunother., 32: 185-190, 1990.
24. Weiden, P. L., Breitz, H. B., Seiler, C. A., Bjorn, M. J., Ratliff, B. A., Mallett, R., Beaumier, P. L., Appelbaum, J. W., Fritzberg, A. R., and Salk, D. Rhenium-186-labeled chimeric antibody NR-LU-13: pharmacokinetics, biodistribution and immunogenicity relative to murine analog NR-LU-10. J. Nucl. Med., 34: 2111-2119, 1993.
25. Maniatis, T. Fritsch, E. F., and Sambrook, J. Molecular Cloning: A Laboratory Manual, pp. 1.25, 1.74-1.76, 6.30-6.34, 7.12-7.15, 7.26-7.29. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1982.
26. Sanger, F., Nicklen, S., and Coulson, A. R. DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. USA, 74: 5463-5467, 1977.
27. Kabat, E. A., Wu, T. T., Reid-Miller, M., Perry, H. M., and Gottesman, K. S. Sequence of Proteins of Immunological Interest, Ed. 5. Washington, DC: U. S. Department of Health and Human Services, 1991.
28. Pedersen, J. T., Henry, A. H., Searle, S. J., Guild, B. C., Roguska, M., and Rees, A. R. Comparison of surface accessible residues in human and murine immunoglobulin Fv domains: implication for humanization of murine antibodies. J. Mol. Biol., 235: 959-973, 1994.
29. Manheimer-Lory, A., Katz, J. B., Pillinger, M., Ghossein, C., Smith, A., and Diamond, B. Molecular characteristics of antibody bearing an anti-DNA-associated idiotype. J. Exp. Med., 174: 1639-1652, 1991.
30. Martin, R. C., Cheetham, J. C., and Rees, A. R. Modeling antibody hypervariable loops: a combined algorithm. Proc. Natl. Acad. Sci. USA, 86: 9268-9272, 1989.
31. Pedersen, J., Searle, S., Henry, A., and Rees, A. R. Antibody modeling: beyond homology. Immunomethods, 1: 126-136, 1992.
32. Chothia, C., Lesk, A. M., Tramontano, A., Levitt, M., Smith-Gill, S. J., Air, G., Sheriff, S., Padlan, E. A., Davies, D., Tulip, W. R., Colman, P. M., Spinelli, S., Alizari, P. M., and Poljak, R. J. Conformations of immunoglobulin hypervariable regions. Nature (Lond.), 342: 877-883, 1989.
33. Bruccoleri, R. E., and Karplus, M. Prediction of the folding of short polypeptide segments by uniform conformational sampling. Biopolymers. 26: 137-168, 1987.
34. Prodromou, C., and Pearl, L. H. Recursive PCR: a novel technique for total gene synthesis. Protein Eng., 5: 827-829, 1992.
35. Jackson, P. Polyacrylamide gel electrophoresis of reducing saccharides labeled with the fluorophore 2-aminoacridone: subpicomolar detection using an imaging system based on a cooled charged-coupled device. Anal. Biochem., 196: 238-244, 1991.
36. Jackson, P., and Williams, G. R. Polyacrylamide gel electrophoresis of reducing saccharides labeled with the fluorophore 8-aminonaphthalene-1,3,6-trisulphonic acid: applications to the enzymological structural analysis of oligosaccharides. Electrophoresis, 12: 94-96, 1991.
37. Reynolds, J. C., Del Vecchio, S., Sakahara, H., Lora, M. E., Carrasquillo, J. A., Neumann, R. D., and Larson, S. M. Anti-murine antibody response to mouse monoclonal antibodies: clinical findings and implications. Nucl. Med. Biol., 16: 121-128, 1989.
38. Tom, B. H., Rutzky, L. P., Jakstys, M. M., Oyasu, R., Kaye, C. I., and Kahan, B. Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro (Rockville), 12: 180-191, 1976.
39. Wilbur, D. S., Hadley, S. W., Hylarides, M. D., Abrams, P. G., Beaumier, P. A., Morgan, A. C., Reno, J. M., and Fritzberg, A. R. Development of a stable radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer. J. Nucl. Med., 30: 216-226, 1989.
40. Deisenhofer, J. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. Biochemistry, 20: 2361-2370, 1981.
41. Morgan, A. C., Sullivan, W., Graves, S., and Woodhouse, C. S. Murine monoclonal antibody IgG3 to human colorectal tumor associated antigens: augmentation of antibody dependent cell mediated cytotoxicity (ADCC) by IL-2. Cancer Res., 49: 2773-2776, 1989.
42. Bernstein, F. C., Koetzle, T. F., Williams, G. J. B., Meyer, E. F., Brice, M. D., Rodgers, J. R., Kennard, O., Shimanouchi, T., and Tasumi, M. The Protein Databank: a computer based archival file for macromolecular structures. J. Mol. Biol., 112: 535-542, 1977.
43. Kaufman, R. J., Wasley, L. C., Spilotes, S. D., Gossels, S. D., Latt, S. A., Larsen, G. R., and Kay, R. M. Coamplification and coexpression of human tissue type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells. Mol. Cell. Biol., 5: 1750-1759, 1985.
44. Zettlmeissl, G., Ragg, H., and Karges, H. E. Expression of biologically active antithrombin III in Chinese hamster ovary cells. BioTechnology, 5: 720-725, 1987.
45. Page, M. J., and Sydenham, M. A. High level expression of the humanized monoclonal antibody campath-1H in Chinese hamster ovary cells. BioTechnology, 9: 64-68, 1991.
46. Hand, P. H., Calvo, B., Milenic, D., Yokota, T., Finch, M., Snoy, P., Garmestani, K., Gansow, O., Schlom, J., and Kashmiri, S. V. S. Comparative biological properties of a recombinant chimeric anti-carcinoma MAb and a recombinant aglycosylated variant. Cancer Immunol. Immunother., 35: 165-174, 1992.
47. 1 domain of humanized LL2. Glycobiology, 7: 803-809, 1997.