Distribution and binding kinetics of ciprofloxacin and ofloxacin in the hindlimb of the rat

Pharmaceutical Research

Volumn 16, Issue 4, 1999, Pages 587-591

  Sanchez Navarro, A ^a   Casquero Dorado, A C ^a   Weiss, M ^b  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Hindlimb; Permeability; Pharmacokinetics; Quinolones; Tissue binding

Indexed keywords

CIPROFLOXACIN; OFLOXACIN;

ADOLESCENT; ARTICLE; BINDING KINETICS; DRUG BINDING; DRUG DISTRIBUTION; DRUG PENETRATION; FEMALE; HINDLIMB; INTRAARTERIAL DRUG ADMINISTRATION; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; BINDING SITES; CIPROFLOXACIN; FEMALE; HINDLIMB; MATHEMATICAL COMPUTING; MODELS, CHEMICAL; OFLOXACIN; PERFUSION; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 0032935066     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011939616948     Document Type: Article

References (15)

1. 1. S. Allard, M. Kinzig, G. Boivin, F. Sörgel, and M. LeBel. Intravenous ciprofloxacin disposition in obesity. Clin. Pharmacol. Ther. 54:368-373 (1993).
2. 2. J. H. Yuk, C. H. Nightingale, R. Quintiliani, and K. R. Sweeney. Bioavailability and pharmacokinetics of ofloxacin in healthy volunteers. Antimicrob. Agents Chemother. 35:384-386 (1991).
3. 3. P. Tega-Isavadharm, D. Keeratithakul, G. Watt, W. H. Kyle, and M. D. Edstein. Measurement of ciprofloxacin in human plasma, whole blood and erythrocites by high-performance liquid chromatography. Ther. Drug Monit. 13:263-267 (1991).
4. 4. B. Rippe and B. Haraldsson. Capillary permeability in rat hind-quarters as determined by estimation of capillary reflection coefficients. Acta Physiol. Scand. 127:289-303 (1986).
5. 5. B. Haraldsson and B. Rippe. Trancapillary clearance of albumin in rat skeletal muscle monitored by external detection. Effects of alteration in capillary surface area. Acta Physiol. Scand. 132: 495-504 (1988).
6. 6. N. H. Ruderman, C. R. S. Houghton, and R. Hems. Evaluation of the isolated perfused rat hindquarters for the study of muscle metabolism. Biochem. J. 124:639-651 (1971).
7. 7. J. Gorski, D. A. Hood, and R. L. Terjung. Blood flow distribution in tissues of perfused rat hindlimb preparations. Am. J. Physiol. 250:E441-E448 (1986).
8. 8. Z. Wu, L. P. Rivory, and M. S. Roberts. Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content and temperature using statistical moment analysis. J. Pharmacokin. Biopharm. 21:653-688 (1993).
9. 9. A. C. Heatherington and M. Rowland. Estimation of reference spaces in the perfused rat hindlimb. Eur. J. Pharm. Sci. 2:261-270 (1994).
10. 10. A. Sanchez-Navarro. A theoretical approach to the estimation of tissue flows using tritiated water as indicator. J. Pharm. Sci. 84:643-646 (1995).
11. 11. A. C. Casquero-Dorado and A. Sanchez-Navarro. The isolated hindlimb preparation as a drug distribution model. Meth. Find. Exp. Clin. Pharmacol. 18:453-458 (1996).
12. 12. M. Weiss and M. S. Roberts. Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: Application of a stochastic model to the rat hindlimb. J. Pharmacokin. Biopharm. 24:173-196 (1996).
13. 13. M. Weiss, A. Koester, Z. Wu, and M. S. Roberts. Distribution kinetics of diazepam, lidocaine and antipyrine in the isolated perfused rat hindlimb. Pharm. Res. 14:1640-1643 (1997)
14. 14. M. Weiss. Distribution kinetics in the body and single organs: moment analysis. In D. Z. D'Argenio (ed.), Advanced methods of pharmacokinetic and pharmacodynamic systems analysis, Vol. 2, Plenum Press, New York, 1995, pp. 89-100.
15. 15. P. O. Iversen, M. Standa, and G. Nicolaysen. Marked regional heterogeneity an blood flow within a single skeletal muscle at rest and during exercise. Acta. Physiol. Scand. 136:17-28 (1989).