The concentrations of clinafloxacin in alveolar macrophages, epithelial lining fluid, bronchial mucosa and serum after administration of single 200 mg oral doses to patients undergoing fibre-optic bronchoscopy

Journal of Antimicrobial Chemotherapy

Volumn 43, Issue 1, 1999, Pages 153-155

  Honeybourne, D ^a   Andrews, J M ^a   Cunningham, B ^a   Jevons, G ^a   Wise, R ^a  

^a CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CLINAFLOXACIN;

ARTICLE; BRONCHUS MUCOSA; CELL LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG TISSUE LEVEL; EPITHELIUM; FEMALE; FIBEROPTIC BRONCHOSCOPY; HUMAN; LUNG ALVEOLUS MACROPHAGE; MALE; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; ORAL DRUG ADMINISTRATION; RESPIRATORY TRACT INFECTION;

ADMINISTRATION, ORAL; ADULT; ANTI-INFECTIVE AGENTS; ANTIBIOTIC PROPHYLAXIS; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBER OPTICS; FLUOROQUINOLONES; HUMANS; MACROPHAGES, ALVEOLAR; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MUCOUS MEMBRANE; TIME FACTORS;

EID: 0032933804     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/43.1.153     Document Type: Article

References (8)

1. Wise, R., Ashby, J. P. & Andrews, J. M. (1988). In vitro activity of PD 127391, an enchanced spectrum quinolone. Antimicrobial Agents and Chemotherapy 32, 1251-6.
2. Norrby, S. R. & Jonsson, M. (1988). Comparative in vitro activity of PD 127391, a new fluorinated 4-quinolone derivative. Antimicrobial Agents and Chemotherapy 32, 1278-81.
3. Bron, N. J., Dorr, M. B., Mant, T. G., Webb, C. L. & Vassos, A. B. (1996). The tolerance and pharmacokinetics of clinafloxacin (Cl-960) in healthy subjects. Journal of Antimicrobial Chemotherapy 38, 1023-9.
4. Andrews, J. M., Honeybourne, D., Brenwald, N. P., Bannerjee, D., Iredale, M., Cunningham, B. et al. (1997). Concentrations of trovafloxacin in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum after administration of single or multiple oral doses to patients undergoing fibre-optic bronchoscopy. Journal of Antimicrobial Chemotherapy 39, 797-802.
5. Bennett, J. V., Brodie, J. L., Benner, E. J. & Kirby, W. M. M. (1966). Simplified, accurate method for antibiotic assay of clinical specimens. Applied Microbiology 14, 170-7.
6. Gooding, B. B., Erwin, M. E., Barrett, M. S., Johnson, D. M. & Jones, R. N. (1992). Antimicrobial activities of two investigational fluoroquinolones (Cl-960 and E 4695) against over 100 Legionella sp. isolates. Antimicrobial Agents and Chemotherapy 36, 2049-50.
7. Honeybourne, D., Andrews, J. M., Ashby, J. P., Lodwick, R. & Wise, R. (1988). Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa. Thorax 43, 715-9.
8. Wise, R. & Honeybourne, D. (1996). A review of the penetration of sparfloxacin into lower respiratory tract and sinuses. Journal of Antimicrobial Chemotherapy 37, Suppl. A, 57-63.