The effect of nitroglycerin on pacing-induced changes in myocardial oxygen consumption and metabolic coronary vasodilation in patients with coronary artery disease

Anesthesia and Analgesia

Volumn 88, Issue 2, 1999, Pages 271-278

  Kal, Jasper E ^a   Vergroesen, Isabelle ^a   Van Wezel, Harry B ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERYL TRINITRATE;

ADULT; AGED; ARTERIAL PRESSURE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DILATATION; CORONARY ARTERY DISEASE; CORONARY HEMODYNAMICS; CORONARY SINUS BLOOD FLOW; HEART ATRIUM PACING; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG CAPILLARY PRESSURE; OXYGEN SATURATION; PRIORITY JOURNAL; SINUS RHYTHM;

BLOOD PRESSURE; CARDIAC OUTPUT; CARDIAC PACING, ARTIFICIAL; CORONARY CIRCULATION; CORONARY DISEASE; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HEMOGLOBINS; HUMANS; INFUSIONS, INTRAVENOUS; MIDDLE AGED; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGLYCERIN; OXYGEN; OXYGEN CONSUMPTION; PULMONARY WEDGE PRESSURE; THERMODILUTION; VASODILATION; VASODILATOR AGENTS;

EID: 0032932653     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199902000-00009     Document Type: Article

References (39)

1. Feigl EO. Coronary physiology. Physiol Rev 1983;63:1-205.
2. Broten TP, Feigl EO. Role of myocardial oxygen and carbon dioxide in coronary autoregulation. Am J Physiol 1992;262: H1231-7.
3. Vergroesen I, Kal JE, Spaan JAE, Van Wezel HB. Myocardial oxygen supply:demand ratio as reference for coronary vasodilatory drug effects in humans. Heart 1997;78:117-26.
4. 2 consumption and arterial pressure as independent determinants of coronary flow. Am J Physiol 1987;252:H545-53.
5. Quyyumi AA, Dakak N, Andrews NP, et al. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 1995;92:320-6.
6. Gilligan DM, Panza JA, Kilcoyne CM, et al. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 1994;90:2853-8.
7. Jones CJ, Kuo L, Davis MJ, et al. Role of nitric oxide in the coronary microvascular responses to adenosine and increased metabolic demand. Circulation 1995;91:1807-13.
8. Abrams J. Hemodynamic effects of nitroglycerin and long-acting nitrates. Am Heart J 1985;110:216-24.
9. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81:491-7.
10. Zeiher AM, Krause T, Schächinger V, et al. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 1995;91:2345-52.
11. Egashira K, Inou T, Hirooka Y, et al. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. N Engl J Med 1993;328:1659-64.
12. Oemar BS, Tschudi MR, Godoy N, et al. Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis. Circulation 1998;97:2494-8.
13. Mathey DG, Chatterjee K, Tyberg JV, et al. Coronary sinus reflux: a source of error in the measurement of thermodilution coronary sinus flow. Circulation 1978;57:778-86.
14. Ganz W, Tamura K, Marcus HS, et al. Measurement of coronary sinus blood flow by contious thermodilution in man. Circulation 1971;44:181-95.
15. Hoffman JIE, Spaan JAE. Pressure-flow relations in coronary circulation. Physiol Rev 1990;70:331-89.
16. Lamprecht W, Stein P, Heinz F. Lactate. In: Methoden der Enzymatischen Analyse. Weinheim. Verlag Chemie, 1974: 1729-37.
17. Vergroesen I, Kal JE, Van Wezel HB. Coronary vasodilating drug effects or normal coronary blood flow regulation? J Cardiothorac Vasc Anesth 1998;12:450-6.
18. Noble MIM. Myocardial supply and demand. Heart 1997;78: 105-6.
19. Harrison DG, Bates JN. The nitrovasodilators: new ideas about old drugs. Circulation 1993;87:1461-7.
20. Ihlen H, Myhre E, Smith HJ. Potential deleterious haemodynamic effects of glyceryl trinitrate on myocardial ischaemia in man. Br Heart J 1984;52:510-5.
21. Choong CY, Freedman SB, Roubin GS, et al. Comparison of the effects of nifedipine and nitroglycerin on hemodynamic determinants of myocardial oxygen consumption and supply during exertional angina. J Cardiovasc Pharmacol 1989;13:361-9.
22. 2 consumption by nitroglycerin during ischemia. Eur J Pharmacol 1985;112:47-55.
23. Fuchs RM, Brinker JA, Guzman PA, et al. Regional coronary blood flow during relief of pacing-induced angina by nitroglycerin: implications for mechanism of action. Am J Cardiol 1983;51:19-23.
24. Van Wezel HB, Kal JE, Vergroesen I, et al. Rate of coronary flow adaptation in response to changes in heart rate before and during anesthesia for coronary artery surgery. Anesthesiology 1996;84:1107-18.
25. Kern MJ, Eilen SD, Park RC, O'Rourke RA. Alterations in regional myocardial blood flow after nitroprusside and nitroglycerin in patients with and without significant coronary artery disease. Am J Cardiol 1986;58:443-8.
26. Davis ME, Jones CJH, Feneck RO, Walesby RK. The effects of intravenous nitroglycerin and isosorbide dinitrate on hemodynamics and myocardial metabolism. J Cardiothorac Anesth 1989;3:712-9.
27. Zhang J, Somers M, Cobb FR. Heterogeneous effects of nitroglycerin on the conductance and resistance coronary arterial vasculature. Am J Physiol 1993;264:H1960-8.
28. Gage JE, Hess OM, Murakami T, et al. Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin. Circulation 1986;73:865-76.
29. Brown BG, Bolson E, Petersen RB, et al. The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. Circulation 1981;64:1089-97.
30. Kanatsuka H, Lamping KG, Eastham CL, Marcus ML. Heterogeneous changes in epimyocardial microvascular size during graded coronary stenosis: evidence of the microvascular site for autoregulation. Circ Res 1990;66:389-96.
31. Parker JD, Parker JO. Nitrate therapy for stable angina pectoris. N Engl J Med 1998;338:520-31.
32. Moffitt EA, Sethna DH, Gray RJ, et al. Rate-pressure product correlates poorly with myocardial oxygen consumption during anaesthesia in coronary patients. Can Anaesth Soc J 1984;31: 5-12.
33. Braunwald E, Sobel BE. Coronary blood flow and myocardial ischemia. In: Braunwald E, ed. Heart disease: a textbook of cardiovascular medicine. London: WB Saunders, 1992:1162-3.
34. Paulus WJ, Vantrimpont PJ, Shah AM. Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans: assessment by bicoronary sodium nitroprusside infusion. Circulation 1994;89:2070-8.
35. Joselevitz-Goldman J, Acad BA, Weiss HR. Effects of nitroglycerin on regional O2 supply and O2 consumption in reperfused dog myocardium. Eur J Pharmacol 1989;166:283-93.
36. Kedem J, Grover GJ, Weiss HR. Nitroglycerin improves the distribution of regional oxygenation in partially ischemic canine myocardium. J Cardiovasc Pharmacol 1985;7:760-6.
37. Sambuceti G, Marzilli M, Marraccini P, et al. Coronary vasoconstriction during myocardial ischemia induced by rises in metabolic demand in patients with coronary artery disease. Circulation 1997;95:2652-9.
38. Nabel EG, Selwyn AP, Ganz P. Paradoxical narrowing of atherosclerotic coronary arteries induced by increases in heart rate. Circulation 1990;81:850-9.
39. Quyyumi AA, Cannon RO, Panza JA, et al. Endothelial dysfunction in patients with chest pain and normal coronary arteries. Circulation 1992;86:1864-71.