Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 5, 1999, Pages 1152-1155

  Garey, Kevin W ^a   Peloquin, Charles A ^b   Godo, Paul G ^b   Nafziger, Anne N ^a,c   Amsden, Guy W ^a,c  

^a BASSETT HEALTHCARE   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c BASSETT RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

14 HYDROXYCLARITHROMYCIN; AZITHROMYCIN; CLARITHROMYCIN; ZAFIRLUKAST;

ADULT; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE;

EID: 0032931676     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.5.1152     Document Type: Article

References (12)

1. Amsden, G. W. 1996. Erythromycin, clarithromycin, and azithromycin: are the differences real? Clin. Ther. 18:56-72.
2. Amsden, G. W. 1995. Macrolides versus azalides: a drug interaction update. Ann. Pharmacother, 29:906-917.
3. Cheng, K. L., A. N. Nafziger, C. A. Peloquin, and G. W. Amsden. 1998. Effect of grapefruit juice on clarithromycin pharmacokinetics. Antimicrob. Agents Chemother. 42:927-929.
4. Gibaldi, M., and D. Perrier. 1975. Pharmacokinetics. Marcel Dekker, Inc., New York, N.Y.
5. Kelloway, J. S. 1997. Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma. Ann. Pharmacother. 31:1012-1021.
6. Langtry, H. D., and R. N. Brogden. 1997. Clarithromycin. A review of its efficacy in the treatment of respiratory tract infections in immunocompetent patients. Drugs 53:973-1004.
7. Morkunas, A., and K. Graeme. 1997. Zafirlukast-warfarin drug interaction with gastrointestinal bleeding. J. Toxicol. Clin. Toxicol. 35:501. (Abstract.)
8. Pharmacia-Upjohn. 1997. Product information, Rescriptor. Pharmacia-Upjohn, Bridgewater, N.J.
9. Tanswell, P., and J. Koup. 1993. TopFit: a PC based pharmacokinetic/ pharmacodynamic data analysis program. Int. J. Clin. Pharmacol. Ther. Toxicol. 31:514-520.
10. Teichtahl, H., N. Buckmaster, and E. Pertnikovs. 1997. The incidence of respiratory tract infection in adults requiring hospitalization for asthma. Chest 112:591-596.
11. Wallace, R. J., Jr., B. A. Brown, D. E. Griffith, W. Girard, and K. Tanaka. 1995. Reduced serum levels of clarithromycin in patients treated with multidrug regimens including rifampin or rifabutin for Mycobacterium avium-M. intracellulare infection. J. Infect. Dis. 171:747-750.
12. Zeneca Pharmaceuticals. 1998. Prod information, Accolate. Zeneca Pharmaceuticals, Wilmington, Del.