Becaplermin

BioDrugs

Volumn 11, Issue 5, 1999, Pages 359-364

  Barman Balfour, Julia A ^a   Noble, Stuart ^a  

^a ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BECAPLERMIN; DERMATOLOGICAL AGENT; DIMER; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; UNCLASSIFIED DRUG;

CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE CALCULATION; DRUG ABSORPTION; DRUG APPROVAL; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TOLERABILITY; EXTRACELLULAR MATRIX; FOOT ULCER; GRANULATION TISSUE; HUMAN; PRIORITY JOURNAL; RASH; REVIEW; STRESS ULCER; TOPICAL DRUG ADMINISTRATION; ULCER HEALING;

EID: 0032931646     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-199911050-00007     Document Type: Review

References (38)

1. Heldin C-H, Östman A, Westermark B. Structure of platelet-derived growth factor: implications for functional properties. Growth Factors 1993; 8: 245-52
2. Rothe MJ, Pesce K, Falanga V. Clinical application of growth factors in cutaneous wound healing: current status. Clin Immunother 1994 Apr; 1: 282-92
3. Kiritsy CP, Lynch SE. Role of growth factors in cutaneous wound healing: a review. Crit Rev Oral Biol Med 1993; 4: 729-60
4. Pierce GF, Mustoe TA, Lingelbach J, et al. Platelet-derived growth factor and transforming growth factor-β enhance tissue repair activities by unique mechanisms. J Cell Biol 1989; 109: 429-40
5. Mustoe TA, Pierce GF, Morishima C, et al. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J Clin Invest 1991; 87: 694-703
6. Heldin C-H, Bäckström G, Östman A, et al. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J 1988; 7: 1387-94
7. Hart CE, Forstrom JD, Kelly RA, et al. Two classes of PDGF receptors recognize different isoforms of PDGF. Science 1988; 240: 1529-31
8. Seifert RA, Hart CE, Phillips PE, et al. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem 1989; 264: 8771-8
9. Peus D, Jungtäuhl H, Knaub S, et al. Localization of platelet-derived growth factor receptor subunit expression in chronic venous leg ulcers. Wound Rep Reg 1995; 3: 265-72
10. Pierce GF, Mustoe TA, Altrock BW, et al. Role of platelet-derived growth factor in wound healing. J Cell Biochem 1991; 45: 319-26
11. Deuel TF. Polypeptide growth factors: roles in normal and abnormal growth. Annu Rev Cell Biol 1987; 3: 443-92
12. Kohler N, Lipton A. Platelets as a source of fibroblast growth-promoting activity. Exp Cell Res 1974; 87: 297-301
13. Pierce GF, Mustoe TA, Senior RM, et al. In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant C-sis gene homodimeric proteins. J Exp Med 1988; 167: 974-87
14. Pierce GF, Tarpley JE, Allman RM, et al. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB. Am J Pathol 1994 Dec; 145: 1399-410
15. Siegbahn A, Hammacher A, Westermark B, et al. Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. J Clin Invest 1990 Mar; 85: 916-20
16. Greenhalgh DG, Sprugel KH, Murray MJ, et al. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 1990 Jun; 136: 1235-46
17. Deuel TF, Senior RM, San Huang J, et al. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J Clin Invest 1982; 69: 1046-9
18. Senior RM, Griffin GL, San Huang J, et al. Chemotactic activity of platelet alpha granule proteins for fibroblasts. J Cell Biol 1983; 96: 382-5
19. Jawien A, Bowen-Pope DF, Lindner V, et al. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest 1992; 89: 507-11
20. Grotendorst GR, Chang T, Seppa HE, et al. Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J Cell Physiol 1982; 113: 261
21. Lepistö J, Laato M, Niinikoski J, et al. Effects of homodimeric isoforms of platelet-derived growth factor (PDGF-AA and PDGF-BB) on wound healing in rat. J Surg Res 1992; 53: 596-601
22. Grotendorst GR, Martin GR, Pencev D, et al. Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. J Clin Invest 1985; 76: 2323-9
23. Pierce GF, Vande Berg J, Rudolph R, et al. Platelet-derived growth factor-BB and transforming growth factor betal selectively modulate glycosaminoglycans, collagen, and myofibroblasts in excisional wounds. Am J Pathol 1991; 138: 629-46
24. Pierce GF, Tarpley JE, Yanagihara D, et al. Platelet-derived growth factor (BB homodimer), transforming growth factor-β1, and basic fibroblast growth factor in dermal wound healing. Am J Pathol 1992; 140: 1375-88
25. Mustoe TA, Purdy J, Gramates P, et al. Reversal of wound healing in irradiated rats by platelet-derived growth factor-BB. Am J Surg 1989; 158: 345-50
26. Brown RL, Breeden MP, Greenhalgh DG. PDGF and TGF-α act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res 1994; 56: 562-70
27. LeGrand EK, Niciporciukas MC, Donetz AP, et al. Comparison of pig and guinea pig full and partial thickness skin excision wound models for evaluating the effects of rhPDGF-BB. Wounds 1995 May-Jun; 7: 78-89
28. Albertson S, Hummel III RP, Breeden M, et al. PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice. Surgery 1993; 114: 368-73
29. Kiritsy CP, Antoniades HN, Carlson MR, et al. Combination of platelet derived growth factor-BB and insulin-like growth factor-1 is more effective than platelet-derived growth factor-BB alone in stimulating complete healing of full-thickness wounds in "older" diabetic mice. Wound Rep Reg 1995; 3: 340-50
30. LeGrand EK, Burke JF, Costa DE, et al. Dose responsive effects of PDGF-BB, PDGF-AA, EGF, and bFGF on granulation tissue in a guinea pig partial thickness skin excision model. Growth Factors 1993; 8 (4): 307-14
31. Engrav LH, Richey KJ, Chi Kao C, et al. Topical growth factors and wound contraction in the rat: Part II. Platelet-derived growth factor and wound contraction in normal and steroid-impaired rats. Ann Plast Surg 1989; 23: 245-8
32. Lynch SE, Colvin RB, Antoniades HN. Growth factors in wound healing. Single and synergislic effects on partial thickness porcine skin wounds. J Clin Invest 1989; 84: 640-6
33. Ortho-McNeil Pharmaceutical. Regranex Gel-U.S full prescribing information. 1998
34. Steed DL, Diabetic Ulcer Study Group. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. J Vasc Surg 1995 Jan; 21: 71-81
35. Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: a phase III randomized placebo-controlled double-blind study. Diabetes Care 1998 May; 21: 822-7
36. d'Hemecourt PA, Smiell JM, Hugill JV, et al. The effect of sodium carboxymethylcellulose gel in patients with nonhealing lower extremity diabetic ulcers. Poster presented at the American College of Surgeons, 83rd Annual Clinical Congress, 1997; Oct 13-16 Chicago
37. Rees RS, Robson MC, Smiell JM, et al. A randomized, double-blind, placebo-controlled study of becaplermin (recombinant human platelet-derived growth factor-BB) gel in the treatment of pressure ulcers. The Wound Healing Society Eighth Annual Meeting, 1998; June 17-20, Salt Lake City
38. Anonymous. Clinical review of BLA-96-1408. OMJ Pharmaceuticals