Combinations of chlorocatechols and heavy metals cause DNA degradation in vitro but must not result in increased mutation rates in vivo

Environmental and Molecular Mutagenesis

Volumn 33, Issue 3, 1999, Pages 202-210

  Schweigert, Nina ^a   Belkin, Shimshon ^b   Leong Morgenthaler, Phaik ^b   Zehnder, Alexander J B ^a   Eggen, Rik I L ^a  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^b NONE

Author keywords

Chlorocatechol; Copper; DNA damage; Marker gene; Mutation; Reactive oxygen species; Structure activity

Indexed keywords

CATECHOL; LEAD;

AMES TEST; ARTICLE; DNA DEGRADATION; ESCHERICHIA COLI; LIPID PEROXIDATION; MUTAGEN TESTING; NONHUMAN; SALMONELLA TYPHIMURIUM; STRUCTURE ACTIVITY RELATION;

CATALASE; CATECHOLS; CHLORINE; COPPER; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HYDROGEN PEROXIDE; IRON; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MUTAGENESIS; MUTAGENICITY TESTS; MUTATION; OXIDATIVE STRESS; PLASMIDS; REACTIVE OXYGEN SPECIES; SALMONELLA; SUPEROXIDE DISMUTASE;

ESCHERICHIA COLI; LETHRINIDAE; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032931488     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1999)33:3<202::AID-EM4>3.0.CO;2-C     Document Type: Article

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