Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia

Journal of Ethnopharmacology

Volumn 65, Issue 1, 1999, Pages 29-51

  Pomilio, Alicia B ^a   Vitale, Arturo A ^a   Ciprian Ollivier, Jorge ^a   Cetkovich Bakmas, Marcelo ^a   Gómez, Raquel ^a   Vazquez G ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Ayahoasca; Gas chromatography mass spectrometry; MAO; Methylated indolalkylamines; Psychodisleptic; Schizophrenia; Transmethylation hypothesis

Indexed keywords

AYAHOASCA EXTRACT; AYURVEDIC DRUG; HYDROCORTISONE; PROLACTIN; PSYCHEDELIC AGENT; SEROTONIN; UNCLASSIFIED DRUG;

ARTICLE; BOTANY; CONTROLLED STUDY; DRINKING; DRUG ACCUMULATION; DRUG POTENCY; ENZYME ACTIVITY; ETHNOPHARMACOLOGY; EXTRACTION; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; MASS SPECTROMETRY; METHYLATION; NORMAL HUMAN; PHYTOCHEMISTRY; PHYTOTOXICITY; PROLACTIN BLOOD LEVEL; PSYCHOMETRY; PSYCHOSIS; SCHIZOPHRENIA; SEROTONIN BLOOD LEVEL; SOUTH AMERICA; TEA;

GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALLUCINOGENS; HUMANS; HYDROCORTISONE; N,N-DIMETHYLTRYPTAMINE; PLANT EXTRACTS; PROLACTIN; SCHIZOPHRENIA; SEROTONIN; SOUTH AMERICA;

EID: 0032931248     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(98)00163-9     Document Type: Article

References (126)

1. Aghajanian, G.K., Marek, G.J. 1994. Serotonin-activated cortical interneurons: physiology and pharmacology. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin. 30 July-3 August, Chicago, IL, p. 47.
2. Agurell, S., Holmstedt, B., Lindgren, J.-E., Schultes, R.E., 1968 a. Identification of two new β-carboline alkaloids in South American hallucinogenic Plants. Biochemical Pharmacology 17, 2487-2488.
3. Agurell, S., Holmstedt, B., Lindgren, J.-E., 1968b. Alkaloid content of Banisteriopsis Rusbyana. American Journal of Pharmacy 140, 148-151.
4. Agurell, S., Holmstedt, B., Lindgren, J.-E., Schultes, R.E., 1969. Alkaloids in certain species of Virola and other South American plants of ethnopharmacologic interest. Acta Chemica Scandinavica 23, 903-916.
5. Aranha, C., Travaini, G., Correa, M.A., 1991. Aspectos botánicos e taxonómicos das plantas Banisteriopsis sp. e Psychotria sp. 1st Congresso em Saude, Centro de Estudos Medicos, União do Vegetal, São Paulo, Brasil, 30 May-2 June.
6. Arnason, T., Uck, F., Lambert, J., Hebda, R., 1980. Maya medicinal plants of San José Succotz, Belize. Journal of Ethnopharmacology 2, 345-364.
7. Biocca, E., Galeffi, C., Montalvo, E.G., Marini-Bettolo, G.B., 1964. Sulle sostanze allucinogene impiegate in Amazonia. Nota I. Osservazioni sul Paricá dei Tukano e Tariana del bacino del Rio Vaupés. Annales di Chimica (Roma) 54, 1175-1178.
8. Buckholtz, N.S., Boggan, W.O., 1977. Monoamine oxidase inhibition in brain and liver produced by β-carbolines: structure-activity relationships and substrate specificity. Biochemical Pharmacology 26, 1991-1996.
9. Buscaíno, G.A., Spadetta, V., Carella, A., 1966. Possible applicazione del test di metilazione in vitro della nicotinamide alia diagnosi biochimica della schizophrenia. Acta Neurologica 21, 1-5.
10. Buscaíno, G.A., Spadetta, V., Carella, A., 1969. Il test de la metilazione nella schizophrenia. Considerazione su una casuística de 500 sperimentazioni. Acta Neurologica 24, 113-118.
11. Checkley, S.A., Murray, R.M., Oon, M.C., Rodnight, R., Birley, J.L., 1980. A longitudinal study of urinary excretion of N,N-dimethyltryptamine in psychotic patients. British Journal of Psychiatry 137, 236-239.
12. Chen, A.L., Chen, K.K., 1939. Harmine, the alkaloid of caapi. Quarterly Journal of Pharmacy and Pharmacology 12, 30-38.
13. Ciccocioppo, R., Polidori, C., Massi, M., Panocka, I., 1994. GR113808A, a highly selective antagonist at 5-HT4 receptors, reduces alcohol intake in Sardinian alcohol-preferring rats. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 117.
14. Ciprian-Ollivier, J., 1991. Delusional status and abnormally methylated compounds. In: Racagni, G., Brunello, N., Fukuda, T., (Eds.), Biological Psychiatry, Proceedings of the 5th World Congress of Biological Psychiatry. Florence, 9-14 June. Excerpta Medica, Amsterdam, pp. 627-629.
15. Ciprian-Ollivier, J., Cetkovich-Bakmas, M.G., Boullosa, O., 1986. Abnormally methylated compounds in mental illness. In: Shagass C. et al., (Eds.), Biological Psychiatry 1985. Elsevier, New York, pp. 243-245.
16. Ciprian-Ollivier, J., Cetkovich-Bakmas, M.G., Boullosa, O., López-Mato, A., 1988. Psicosis esquizofrénicas. Teoría de la transmetilación patológica. In: Ciprian-Ollivier, J., (Ed.), Psiquiatría Biológica. Fundamentos y Aplicación Clínica. Ed. Científica Interamericana, Buenos Aires, pp. 75-87.
17. Clinquart, E., 1926. Contribution a l'étude de la liane Yagé et de son alcaloide. Journal of Pharmacology (Belgium) 36, 671-674.
18. Costall, B., Naylor, R.J., 1994. Atypical neuroleptic agents interact at the 5-HT2A/2C receptors to reduce anxiety-like responding. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, Chicago, IL, 30 July-3 August, p. 65.
19. Davis, B.A., Yu, P.A., Carlsson, H., 1982. Plasma levels of phenyl acetic acid and p-hydroxyphenylacetic acid and platelet monoaminooxidase activity in schizophrenic and other patients. Psychiatry Research 6, 97-105.
20. Davis, K.L., Kahn, R.S., Ko, G., Davidson, M., 1991. Dopamine in schizophrenia: a review and reconceptualization. American Journal of Psychiatry 148, 1474-1486.
21. Dawson, G., 1965. Malpighiaceae. In: Cabrera, A.L. (Ed.), Flora de Buenos Aires, Colección Científica del INTA, 4, pp. 48-57.
22. Del Castillo, G., 1962. Observaciones sobre la intoxicación aguda provocada en el hombre por la ingestión del Ayahuasca. Thesis. Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú.
23. Delgado, M.C., Urzúa, A., Cassels, B.K., 1972. Tribal and urban healing with hallucinogenic beverages in Amazonian Perú. American Journal of Pharmacy 144, 187-190.
24. Der Marderosian, A.H., Kensinger, K., Chao, I., Goldstein, F., 1970. The use and hallucinatory principles of a psychoactive beverage of the Cashinahua tribe (Amazon Basin). Drug Dependence 5, 7-14.
25. Der Marderosian, A.H., Pinkley, H.V., Dobbins, M.F., 1968. Native use and occurrence of N,N-dimethyltryptamine in the leaves of Banisteriopsis Rusbyana. American Journal of Pharmacy 140, 137-147.
26. Deulofeu, V., 1967a. Plantas alucinógenas americanas. Ciencia e Investigación 23, 195-206.
27. Deulofeu, V., 1967b. Chemical compounds isolated from Banisteriopsis and related species. In: Efron, D.H., Holmstedt, B., Kline, N.S. (Eds.), Ethnopharmacologic Search for Psychoactive Drugs. US Department of Health, Education, and Welfare, Public Health Service Publication No. 1645, Washington DC, pp. 393-402.
28. Diagnostic Products Corporation (1985). Cortisol Double Antibody, Protocol D563, 30 December, pp. 1-13.
29. Dobkin de Ríos, M., 1970. Banisteriopsis in witchcraft and healing activities in Iquitos, Perú. Economic Botany 24, 296-300.
30. Dobkin de Ríos, M., 1972. Visionary vine: psychedelic healing in the Peruvian Amazon. International Journal of Social Psychiatry 17, 256-269.
31. 3H]GR 113808 to 5-HT4 receptors in human frontal cortex. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 84.
32. Ducke, A., 1958. Capi, Caapi, Gabi, Ayahuasca e Yagé. Anais Academia Brasileira do Ciencias 30, 207.
33. Efron, D. H., Holmstedt, B., Kline, N.S. (Eds.), 1967. Ethnopharmacologic Search for Psychoactive Drugs. US Department of Health, Education, and Welfare, Public Health Service Publication No. 1645, Washington DC (Proceedings of a Symposium held in San Francisco, 28-30 January, California).
34. Eison, A.S., 1994. Regulation of central 5-HT2 receptors: in vivo studies. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 38.
35. Fischer, E., Spatz, H., Fledel, T., 1971. Bufotenin like substances in form of glucuronide in schizophrenic and normal urines. Psychosomatics 12, 278-280.
36. Flores, F.A., Lewis, W.H., 1978. Drinking the South American hallucinogenic Ayahuasca. Economic Botany 32, 154-156.
37. Friedhoff, A.J., Van Winkle, E., 1964. Biological O-methylation and schizophrenia. Psychiatric Research Report 19. American Psychiatric Association, December, 149-153.
38. Fuller, R.W., Warren, B.J., Molloy, B.B., 1970. Selective inhibition of monoamine oxidase in rat brain mitochondria. Biochemical Pharmacology 19, 2934-2936.
39. Fuller, R.W., Perry, K.W., Snoddy, H.D., 1994. Tissue distribution and metabolism of bufotenine administered to rats. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 115.
40. Gates, B., 1979. New names in Banisteriopsis and Diplopterys (Malpighiaceae) of the Guayana Highland. Brittonia 31, 108-109.
41. Gates, B., 1982. Banisteriopsis, Diplopterys. In: Flora Neotropica, Monograph No. 30, pp. 1-237.
42. Guéritte-Voegelein, F., Sévenet, T., Pusset, J., et al., 1992. Alkaloids from Psychotria oleoides with activity on growth hormone release. Journal of Natural Products 55, 923-930.
43. Hashimoto, Y., Kawanishi, K., 1975. New organic bases from Amazonian Banisteriopsis caapi. Phytochemistry 14, 1633-1635.
44. Hashimoto, Y., Kawanishi, K., 1976. New alkaloids from Banisteriopsis caapi. Phytochemistry 15, 1559-1560.
45. Hegnauer, R. (1990) Chemotaxonomie der Pflanzen, vol. 9, Malpighiaceae; Rubiaceae. Birkhäuser, Basel, pp. 13-16 and 405-436.
46. Heym, J., Jacobs, B.L., 1987. Serotonergic mechanisms of hallucinogenic drug effects. Monography on Neural Science 13, 55-81.
47. Hochstein, F.A., Paradies, A.M., 1957. Alkaloids from Banisteriopsis caapi and Prestonia amazonicum. Journal of the American Chemical Society 79, 5735-5736.
48. Holmstedt, B., Lindgren, J.-E., 1967. Chemical constituents and pharmacology of South American snuffs. In: Efron, D. H., Holmstedt, B., Kline, N.S. (Eds.), Ethnopharmacologic Search for Psychoactive Drugs. US Department of Health, Education, and Welfare, Public Health Service Publication No. 1645, Washington DC, pp. 339-373.
49. Hryhorczuk, L.M., Rainey, J.M., Frohman, C.E., Novak, E.A., 1986. A new metabolic pathway for N,N-dimethyltryptamine. Biological Psychiatry 21, 84-93.
50. Iacobucci, G.A., Rúveda, E.A., 1964. Bases derived from tryptamine in Argentina Piptadenia species. Phytochemistry 3, 465-467.
51. Iqbal, N., Asnis, G.M., Wetzler, S., Kahn, R.S., Van Praag, H.M., 1991. The MCPP challenge test in schizophrenia: hormonal and behavioral responses. Biological Psychiatry 30, 770-778.
52. Johnson, E.A., Fox, J.L., Azzaro, A.J., 1994. Anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 96.
53. Kawanishi, K., Uhara, Y., Hashimoto, Y., 1982. Shihunine and dihydroshihunine from Banisteriopsis caapi. Journal of Natural Products 45, 637-639.
54. Kuccharewicz, S., Zgombick, J.M., Adham, N., Weinshank, R.L., Branchek, R.A., 1994. Binding profile assessment of hallucinogenic compounds at cloned humans 5-HT1 receptors. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July- 3 August, Chicago, IL, p. 116.
55. Lersten, N.R., 1975. Colleter types in Rubiaceae, especially in relation to the bacterial leaf nodule symbiosis. Botanic Journal of Linnean Society 71, 311-319.
56. Lewis, W.H., Elvin-Lewis, M.P.F., 1977. Hallucinogens. In: Medical Botany: Plants Affecting Man's Health, chap. 18. Wiley, New York, pp. 413-415.
57. Libot, F., Miet, C., Kunesch, N., Poisson, J.E., Pusset, J., Sévenet, T., 1987. Rubiacées d'Océanie: Alcaloïdes de Psychotria oleoides de Nouvelle-Calédonie et de Calycodendron milnei du Vanuatu (Nouvelles-Hébrides). Journal of Natural Products 50, 468-473.
58. Lindenmayer, J.P., 1992. Behavioral response to MCPP challenge in chronic schizophrenia. Proceedings of the 18th Collegium Internationale Neuropsychopharmacologicum Congress Clinical Neuropharmacology, 15, Suppl. 1-B 23, Raven Press, New York.
59. Luna, L.E., 1984. Healing practices of a Peruvian shaman. Journal of Ethnopharmacology 11, 123-133.
60. Magnin, J., 1740. Breve descripción de la Provincia de Quito, y de sus Misiones de sucumbíos de Religiosos de S. Franco, y de Maynes de Pp. de la Compa. de Jhs. a las orillas del gran Río Marañón (hecha para el mapa que se elaboró en 1740), Revista de las Indias 1, No.1, pp. 151-185.
61. Marini-Bettolo, G.B., Delle Monache, F., Biocca, E., 1964. Sulle sostanze allucinogene impiegate in Amazonia. Nota II. Osservazioni sull'Epená degli Yanoáma del bacino del Rio Negro e dall'alto Orinoco. Annales di Chimica (Roma) 54, 1179-1186.
62. Mc Geer, P.L., Eccles, J.C., Mc Geer, E.G., 1978. Molecular Neurobiology of the Mammalian Brain. Plenum, New York.
63. McIsaac, W.M., Estevez, V., 1966. Structure-action relationships of β-carbolines as monoamine oxidase inhibitors. Biochemical Pharmacology 26, 1625-1627.
64. McKenna, D.J., Towers, G.H.N., 1985. On the comparative ethnopharmacology of the malpighiaceous and myristicaceous hallucinogens. Journal of Psychoactive Drugs 17, 35-39.
65. McKenna, D. J., Towers, G.H.N., Abbott, F., 1984. Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and β-carboline constituents of Ayahuasca. Journal of Ethnopharmacology 10, 195-223.
66. McKenna, D.J., Luna, L.E., Towers, G.H.N., 1986. Ingredientes biodinámicos en las plantas que se mezclan al Ayahuasca. Una farmacopea tradicional no investigada. América Indígena 46, 73-101.
67. Müller-Spahn, F., 1992. Risperidone in the treatment of chronic schizophrenic patients: an international double blind parallel group study versus haloperidol. In: Proceedings of the 18th Collegium Internationale Neuropsychopharmacologicum Congress. Clinical Neuropharmacology, 15 Suppl. 1A pp. 90-91.
68. Murray, R.M., Oon, M.C., Rodnight, R., Birley, J.L., Smith, A., 1979. Increased excretion of dimethyltryptamine and certain features of psychosis: a possible association. Archives of General Psychiatry 36, 644-649.
69. Naranjo, C., 1967. Psychotropic properties of the harmala alkaloids. In: Ethnopharmacologic Search for Psychoactive Drugs. US Department of Health, Education, and Welfare, Public Health Service Publication No. 1645, Washington DC, pp. 385-391.
70. Naranjo, P., 1979. Hallucinogenic plant use and related indigenous belief systems in the Ecuadorian Amazon. Journal of Ethnopharmacology 1, 121-145.
71. Naranjo, P., 1986. El Ayahuasca en la arqueología ecuatoriana. América Indígena 46, 117-128.
72. Nelson, D.L., Glennon, R.A., Wainscott, D.B., 1994. Comparison of the affinities of hallucinogenic phenylalkylamines at the cloned human 5-HT2A, 2B and 2C receptors. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 116.
73. O'Donell, C., Lourteig, A., 1943. Malpighiaceae Argentinae. Lilloa 9, 221-316.
74. Palacios, J.M., Mengod, G., Pompeiano, M., Waeber, C., 1994. Binding sites for hallucinogenic drugs in the brain: relationship to serotonin receptors. Abstract S-182-774, XIX C.I.N.P. Congress, 27 June-1 July 1994, Washington, DC, USA.
75. Pennes, H.H., Hoch, P.H., 1957. Psychotomimetics, clinical and theoretical considerations: harmine, WIN-2299 and naline. American Journal of Psychiatry 113, 885-892.
76. Pinkley, H.V., 1969. Plant admixtures to Ayahuasca, the South American hallucinogenic drink. Lloydia 32, 305-314.
77. Pomilio, A.B., 1995. Separación de aminas biogénicas mediante cromatografia liquida de alta resolución. Acta Bioquímica Clínica Latinoamericana 29, 3-36.
78. Prance, G.T., 1970. Notes on the use of plant hallucinogens in Amazonian Brazil. Economic Botany 24, 62-68.
79. Prance, G.T., Prance, A.E., 1970. Hallucinations in Amazonia. Garden Journal 20, 102-107.
80. Prescott, R., Kendall-Taylor, P., Weightman, D., Watson, M., Ratcliffe, W., 1984. The effect of ketanserin, a specific serotonin antagonist, on the PRL, GH, ACTH, and cortisol responses to hypoglycemia in normal subjects. Clinical Endocrinology 20, 137-142.
81. Räisänen, M., Kärkkäinen, J., 1978. Quantitative assay of the N-methylated metabolites of tryptamine and serotonin by gas chromatography-mass spectrometry as applied to the determination of lung indole-ethylamine N-methyltransferase activity. Biomedical Mass Spectrometry 5, 596-600.
82. Räisänen, M., Kärkkäinen, J., 1979. Mass fragmentographic quantification of urinary N,N-dimethyltryptamine and bufotenine. Journal of Chromatography 162, 579-584.
83. Rattle, S.J., Purnell, D.R., Williams, P., Siddle, K., Forrest, G.C., 1984. New separation method for monoclonal immunoradiometric assays and its application to assays for thyrotropin and human choriogonadotropin. Clinical Chemistry 30, 1457-1462.
84. Reichel-Dolmatoff, G., 1970. Notes on cultural extent of the use of yajé (Banisteriopsis caapi) among the indians of the Vaupés, Colombia. Economic Botany 24, 32-33.
85. Ríos, O., 1962. Aspectos preliminares del estudio fármacopsiquiátrico del Ayahuasca y su principio active. Anales de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú, 45, 22-66; Chemical Abstracts 59, 3215 (1963).
86. Ríos, O., 1962. Aspectos preliminares del estudio fármacopsiquiátrico del Ayahuasca y su principio active. Anales de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú, 45, 22-66; Chemical Abstracts 59, 3215 (1963).
87. Rivier, L., Lindgren, J.-E., 1972. Ayahuasca, the South American hallucinogenic drink: an ethnobotanical and chemical investigation. Economic Botany 29, 101-129.
88. Rocha, J., 1905. Memorandum de viaje (regiones amazónicas). El Mercurio, Bogotá, p. 43.
89. Rodnight, R., Murray, R.M., Oon, M.C., Brockington, I.F., Nichols, P., Birley, J.L., 1978. Urinary dimethyltryptamine and psychiatric symptomatology and classification. Psychological Medicine 6, 649-657.
90. Rodríguez, E., Cavin, J.C., West, J.E., 1982. The possible role of Amazonian psychoactive plants in the chemotherapy of parasitic worms - a hypothesis. Journal of Ethnopharmacology 6, 303-309.
91. Rossow, R.A., 1988. Malpighiaceae. In: Correa, M.N. (Ed.), Flora Patagónica, Colección Científica del INTA 8, pp. 57-58.
92. Rouhier, A., 1926. Documents pour servir a l'étude du Yagé. Bulletin des Sciences Pharmacologique 252-261.
93. Rüf, I., 1972. Le 'dutsee tui' chez les indiens Culina de Pérou. Bulletin de la Societé Suisse Americaniste 36, 73-80.
94. Saavedra, J.M., Axelrod, J., 1972. Psychotomimetic N-methylated tryptamines: formation in brain in vivo and in vitro. Science 172, 1365-1366.
95. Schulgin, A.T., 1976. Psychotomimetic agents. In: Gordon, M. (Ed.), Psychopharmacological Agents, vol. IV, chap. 4. Academic Press, New York.
96. Schultes, R.E., 1954. Plantae Austro-Americanae IX. Plantarum novarum vel notabilium notae diversae. Botanical Museum Leaflets, Harvard University 16, 202-205.
97. Schultes, R.E., 1957. The identity of the malpighiaceous narcotics of South America. Botanical Museum Leaflets, Harvard University 18, 1-56.
98. Schultes, R.E., 1967a. The botanical origins of South American snuffs. In: Ethnopharmacologic Search for Psychoactive Drugs. US Department of Health, Education, and Welfare, Public Health Service Publication No. 1645, Washington DC, pp. 291-306.
99. Schultes, R.E., 1967b. The place of ethnobotany in the ethnopharmacologic search for psychotomimetic drugs. In: Ethnopharmacologic Search for Psychoactive Drugs. US Department of Health, Education, and Welfare, Public Health Service Publication No. 1645, Washington DC, pp. 33-57.
100. Schultes, R.E., 1968. Some impacts of Spruce's Amazon explo-rations on modern phytochemical research. Rhodora 70, 313-339.
101. Schultes, R.E., 1969a. Hallucinogens of plant origin. Science 163, 245-254.
102. Schultes, R.E., 1969b. De plantis toxicariis e mundo novo tropicale commentationes IV. Botanical Museum Leaflets, Harvard University 22, 133-164.
103. Schultes, R.E., 1972. De plantis toxicariis e mundo novo tropicale commentationes XI. The ethnotoxicological significance of additives to New World hallucinogens. Plant Science Bulletin 18, 34-40.
104. Schultes, R.E., 1977. The botanical and chemical distribution of hallucinogens. Journal of Psychedelic Drugs 9, 247-263.
105. Schultes, R.E., 1985. Biodynamic rubiaceous plants of the Northwest Amazon. Journal of Ethnopharmacology 14, 105-124.
106. Schultes, R.E., Hofmann, A., 1980. The Botany and Chemistry of Hallucinogens, 2nd ed., Charles C. Thomas, Springfield, IL.
107. Schultes, R.E., Holmstedt, B., Lindgren, J.-E., 1969. De plantis toxicaris e mundo novo tropicale commentationes III. Phytochemical examination of Spruce's original collection of Banisteriopsis caapi. Botanical Museum Leaflets, Harvard University 22, 121-132.
108. Sitaram, B.R., McLeod, W.R., 1990. Observations on the metabolism of the psychomimetic indolealkylamines: Implications for future clinical studies. Biological Psychiatry 28, 841-848.
109. Smythies, J.R., 1983. The transmethylation and one-carbon cycle hypothesis of schizophrenia. Psychological Medicine 13, 711-714 (Editorial).
110. Stam, F.C., Heslinga, F.J.M., Van Tilburg, W., 1969. Schizophrenia and pink spot. Psychiatria, Neurologia, Neurochirurgia 72, 513-524.
111. Steward, L.J, Brown, D.C., Stokes, P.R.A., Barnes, N.M., 1994. Antagonism of the (S)-zacopride-induced increase in dopamine release from rat striatal lices by the 5-HT4 receptor antagonist SDZ 205-557. Abstracts of the 3rd UPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 84.
112. Strahilevitz, M., Narasimhachari, N., Fischer, G.W., Meltzer, H.Y., Himwich, H.E., 1975. Indolethylamine-N-methyltransferase activity in psychiatric patients and controls. Biological Psychiatry 10, 287-302.
113. Strassman, R.J., 1994. Human psychopharmacology of N,N-dimethyltryptamine. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 23.
114. Strassman, R.J., Qualls, C.R., 1994. Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic and cardiovascular effects. Archives of General Psychiatry 51, 85-97.
115. Strassman, R.J., Qualls, C.R., Uhlenhuth, E., Kellner, R., 1994. Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale. Archives of General Psychiatry 51, 98-108.
116. Szára, S., 1956. Dimethyltryptamine: its metabolism in man; the relation of its psychotic effect to the serotonin metabolism. Experientia 12, 411-441.
117. Tanimukai, H., Ginther, R., Spaide, J., Bueno, J.R., Himwich, H.E., 1970. Detection of psychotomimetic N,N-dimethylated indoleamines in the urine of four schizophrenic patients. British Journal of Psychiatry 117, 421-430.
118. Tuomisto, J., Mannisto, P., 1985. Neurotransmitter regulation of anterior pituitary hormones. Pharmacological Reviews 37, 249-332.
119. Udenfriend, S., Witkop, B., Redfield, B.G., Weissbach, H., 1958. Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds. Biochemical Pharmacology 1, 160-165.
120. Van der Karr, L., Lorens, S., Urban, J., Bethea, C., 1989. Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonists on prolactin secretion. Neuropharmacology 28, 299-305.
121. Villavicencio, M., 1858. Geografía de la República del Ecuador. Robert Craighead, New York, pp. 373-374.
122. Vitale, A.A., Calviño, M.A., Ferrari, C., Pomilio, A.B., Ciprian-Ollivier, J., Cetkovich-Bakmas, M., 1995. Método rápido y sensible para detectar aminas primarias y secundarias no fenólicas en orina humana. Acta Bioquímica Clínica Latinoamericana 29, 37-46.
123. Wagner, H., Bladt, S., Zgainski, E.M., 1984. Plant Drug Analysis. Springer, Berlin, p. 51.
124. 3H]GR 113808 Binding to 5-HT4 Receptors in postmortem human brain. Abstracts of the 3rd IUPHAR Satellite Meeting on Serotonin, 30 July-3 August, Chicago, IL, p. 85.
125. Wyatt, R.J., Gillin, J.J., 1976. The transmethylation hypothesis: a quarter of a century later. Psychiatric Annals 6, 35-49.
126. Yasuhara, H., Sho, S., Kamijo, K., 1972. Differences in the actions of harmine on the oxidations of serotonin and tyramine by beef brain mitochondrial MAO. Japanese Journal of Pharmacology 22, 439-441.