Effect of variation in the apo A-IV gene on body mass index and fasting and postprandial lipids in the European atherosclerosis research study II

Journal of Lipid Research

Volumn 40, Issue 2, 1999, Pages 287-294

  Fisher, Rachel M ^a   Burke, Heidi ^a   Nicaud, Viviane ^b   Ehnhohm, Christian ^c   Humphries, Steve E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HÔPITAL BROUSSAIS   (France)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

HDL; Satiety; Triacylglycerol

Indexed keywords

APOLIPOPROTEIN A4; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; DNA; GLUTAMINE; HISTAMINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SERINE; THREONINE; TRIACYLGLYCEROL; APOLIPOPROTEIN A; APOLIPOPROTEIN A-IV; RESTRICTION ENDONUCLEASE;

ADULT; AREA UNDER THE CURVE; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POSTPRANDIAL STATE; PRIORITY JOURNAL; ADOLESCENT; ALLELE; ARTERIOSCLEROSIS; BLOOD; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; METABOLISM; OBESITY; PHYSIOLOGY;

ADOLESCENT; ADULT; ALLELES; APOLIPOPROTEINS A; ARTERIOSCLEROSIS; BODY MASS INDEX; DNA RESTRICTION ENZYMES; FASTING; FEMALE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; LIPIDS; MALE; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POSTPRANDIAL PERIOD; VARIATION (GENETICS);

EID: 0032930675     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0022-2275(20)33368-x     Document Type: Article

References (61)

1. Green, P. H. R., R. M. Glickman, J. W. Riley, and K. Quinet. 1980. Human apolipoprotein A-IV: intestinal origin and distribution in plasma. J. Clin. Invest. 65: 911-919.
2. Utermann, G., and U. Beisiegel. 1979. Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Eur. J. Biochem. 99: 333-343.
3. Steinmetz, A., and G. Utermann. 1985. Activation of lecitin:cholesterol acyltransferase by human apolipoprotein A-IV. J. Biol. Chem. 260: 2258-2264.
4. Chen, C. H., and J. J. Albers. 1985. Activation of lecithin:cholesterol acyltransferase by human apolipoproteins E-2, E-3, and A-IV. Biochim. Biophys. Acta. 836: 279-285.
5. Main, L. A., T. Ohnishi, and S. Yokovama. 1996. Activation of human plasma cholesteryl ester transfer protein by human apolipoprotein A-IV. Biochim. Biophys. Acta. 1300: 17-24.
6. Steinmetz, A., R. Barbaras, N. Ghalim, V. Clavey, J-C. Fruchart, and G. Ailhaud. 1990. Human apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells. J. Biol. Chem. 265: 7859-7863.
7. Stein, O., Y. Stein, M. Lefevre, and P. S. Roheim. 1986. The role of apolipoprotein A-IV in reverse cholesterol transport studied with cultured cells and liposomes derived from an ether analog of phosphatidylcholine. Biochim. Biophys. Acta. 878: 7-14.
8. Dvorin, E., N. L. Gorder, D. M. Benson, and A. M. Gotto. 1986. Apolipoprotein A-IV: a determinant for binding and uptake of high density lipoproteins by rat hepatocytes. J. Biol. Chem. 261: 15714-15720.
9. Savion, N. and A. Gamliel. 1988. Binding of apolipoprotein A-1 and apolipoprotein A-IV to cultured bovine aortic endothelial cells. Arteriosclerosis. 8: 178-184.
10. Weinberg, R. B., and C. S. Patton. 1990. Binding of human apolipoprotein A-IV to human hepatocellular plasma membranes. Biochim. Biophys. Acta. 1044: 255-261.
11. Barter, P. J., O. V. Rajaram, I., B. F. Chang, K. K. Rye, P. Gambert, I.. Lagrost, G. Enholm, and N. H. Fidge. 1988. Isolation of a high density lipoprotein conversion factor from human plasma: a possible role of apolipoprotein A-IV as its activator. Biochem. J. 254: 179-184.
12. Goldberg, I. J., C. A. Scheraldi, L. K. Yacoub, U. Saxena, and C. L. Bisgaier. 1990. Lipoprotein apoC-II activation of lipoprotein lipase. Modulation hy apolipoprotein A-IV. J. Biol. Chem. 265: 4266-4272.
13. Duverger, N., G. Tremp, J. M. Caillaud, F. Emmannel, G. Castro, J. G. Fruchart, A. Steinmetz, and P. Denelle. 1996. Protection against atherogenesis in mice mediated by human apolipoprotein A-IV. Science. 273: 966-968.
14. Cohen, R. D., L. VV. Castellani, J. H. Qiao, B. J. Van Lenten, A. J. Lusis, and K. Reue. 1997. Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV. J. Clin. Invest. 99: 1906-1916.
15. Weinstock, P. H., C. L. Bisgaier, I. Hayek, K. Aalto-Setälä, E. Sehayek, L. Wu, P. Sheiffele, M. Merkel, A. D. Essenburg, and J. L. Breslow. 1997. Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apoliprotein A-IV knockout mice. J. Lipid Res. 38: 1782-1794.
16. Krause, B. R., G. H. Sloop, C. K. Castle, and P. S. Roheim. 1981. Mesenteric lymph apolipoproteins in control and ethinyl estradiol-trealed rats: a model for studying apolipoproteins of intestinal origin. J. Lipid Res. 22: 610-619.
17. Hayashi, H., D. J. Nutting, K. Fujimoto, J. A. Cardelli, D. Black, and P. Tso. 1990. Transport of lipid and apolipoproteins A-I and A-IV in intestinal lymph of the rat. J. Lipid Res. 31: 1613-1625.
18. Kujimoto, K., K. Fukagawa, T. Sakata, and P. Tso. 1993. Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats. J. Clin. Invest. 91: 1830-1833.
19. Kujimoto, K., H. Machidori, R. Iwakiri, K. Yamamoto, J. Fujisaki, T. Sakata, and P. Tso. 1993. Effect of intravenous administration of apolipoprotein A-IV on patterns of feeding, drinking and ambulatory activity of rats, Brain Res. 608: 233-237.
20. Kujimoto, K., J. A. Cardelli, and P. Tso. 1992. Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation. Am. J. Physiol. 262: G1002-1006.
21. Okumura, T., K. Fukagawa, P. Tso, I. L. Taylor, and T. N. Pappas. 1995. Mechanism of action of intracisternal apolipoprotein A-IV in inhibiting gastric acid secretion in rats, Gastroentorology. 109: 1583-1588.
22. Okumura, T., K. Fukagawa, P. Tso, I. L. Taylor, and T. N. Pappas. 1994. Intracisternal injection of apolipoprolein ATV inhibits gastric secretion in pylorus-ligated conscious rats. Gastroenterology. 107: 1861-1864.
23. Aalto-Setälä, K., G. L. Bisgaier, A. Ho, K. A. Kielt, M. G. Traber, H. J. Kayden, R. Ramakrishnan, A. Walsb, A. D. Essenburg, and J. L. Breslow. 1994. Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior. J. Clin. Invest. 93: 1776-1786.
24. Karathanasis, S. K. 1985. Apolipoprotein multigene family: tandem organization of human apolipoprotein A-I, C-III, and A-IV genes. Proc. Natl. Acad. Sci. USA. 82: 6374-6378.
25. Karathanasis, S. K., P. Oettgen, I. A. Hassad, and S. E. Antonarkis. 1986. Structure, evolution and polymorphisms of the human apolipoprotein A-IV gene (APOA4). Pror. Natl. Acad. Sci. USA. 83: 8457-8461.
26. Elshourbagy, N. A., D. W. Walker, Y-K. Paik, M. S. Boguski, M. Freeman, J. I. Gordon, and J. M. Taylor. 1987. Structure and expression of the human apolipoprotein A-IV gene. J. Biol. Chem. 262: 7973-7981.
27. Boerwinkle, E., S. Visvikis. and L. Chan. 1990. Two polymorphisms for amino and substitutions in the APOA4 gene. Nucleic Acids Res. 18: 4966.
28. Menzel, H. J., P. M. Kovary, and G. Assman. 1982. Apolipoprotein A-IV polymorphism in man. Hum. Genet. 62: 349-352.
29. Lohse, P., M. R. Kindt, D. J. Rader, and H. B. Brewer, Jr. 1990. Genetic polymorphism of human plasma A-IV is due to nucleolide substitutions in the apolipoprotein A-IV gene. J. Biol. Chem. 265: 10061-10064.
30. Saha, N. G. Wang, S. Vasisht, and M. I. Kamboh. 1997. Influence of two apoA4 polymorphisms at codons 347 and 360 on non-tasting plasma lipoprotein-lipids and apolipoproteins in Asian Indians. Atherosclerosis. 131: 249-255.
31. Jansen, S., J. Lopez-Miranda, J. Salas, J. M. Ordovas, P. Castro, C. Marin, M. A. Ostos, F. Lopez-Segura, J. A. Jimenez-Pereperez, A. Blanco, and F. Perez-Jimenez. 1997. Effect of 347-serine mutation in apoprotein A-IV on plasma LDL cholesterol response to dietary fat. Arterioscler. Thromb. Vasc. Biol. 17: 1532-1568.
32. Jausen, S., J. Lopez.-Miranda, J. M. Ordovas, J. L. Zambrana, C. Marin, M. A. Ostos, P. Castro, R. McPherson, F. Lopez Segura, A. Blanco. J. A. Jimenez-Pereperez, and F. Perez-Jimenez. 1997. Effect of 360His mutation in apolipoprotein A-IV on plasma HDL-choleslerol response to dietary fat. J. Lipid Res. 38: 1995-2002.
33. Rader, D. J., J. Schäfer, P. Lohse, B. Verges, M. Kindt, L. A. Zech, A. Steinmetz, and H. B. Brewer, Jr. 1993. Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein. J. Clin. Invest. 92: 1009-1017.
34. Weinberg, R. B., M. K. Jordan, and A. Steinmetz. 1990. Distinctive structure and function of human apolipoprotein variant apoA-IV-2. J. Biol. Chem. 265: 18372-18378.
35. Rewers, M., M. I. Kamboh, S. Hoag, S. M. Shetterlv, R. E. Ferrell, and R. F. Hamman. 1994. ApoA-IV polymorphism associated with myocardial infarction in obese NIDDM patients. The San Luis Valley Diabetes Study. Diabetes. 43: 1485-1489.
36. Campos, H., J. López Miranda, C. Rodríguez, M. Albajar, E. J. Schaefer, and J. M. Ordovás. 1997. Urbanization elicits a more atherogenic lipoprotein profile in carriers of the apolipoprotein A-IV-2 allele than in A-IV-1 homozygotes. Arterioscler. Thromb. Vasc. Biol. 17: 1074-1081.
37. The EARS group. 1994. The European Atherosclerosis Research Study (EARS): design and objectives. Int. J. Epidemiol. 23: 465-471.
38. The EARS group. 1994. The distribution of fasting plasma lipid concentrations in the offspring of men with premature coronary heart disease in Europe. The EARS Study. Int. J. Epidemiol. 23: 472-481.
39. Hannuksela, M., Y. L. Marcel, V. A. Kesäniemi, and M. J. Savolainen. 1992. Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol. J. Lipid Res. 33: 737-744.
40. Gioener, J. E. M., R. W. Pelton, and G. M. Kostner. 1986. Improved estimation of cholesteryl ester transfer/exchange activity in serum or plasma. Clin. Chem. 32: 283-286.
41. Hixson, J. E., and P. K. Powers. 1991. Restriction isotyping of human apolipoprotein A-IV: rapid typing of known isoforms and detection of a new isoform that deletes a conserved repeat. J. Lipid Res. 32: 1529-1535.
42. Day, I. N., and S. E. Humphries. 1994. Electrophoresis for genotyping: microtiter array diagonal gel electrophoresis on horizontal polyacrylamide gels, hydrolink, or agarose. Anal. Biachem. 222: 389-395.
43. Tiret, L., P. Amouyel, R. Rakotovao, F. Cambien, and P. Ducimetière. 1991. Testing for association between disease and linked marker loci: a log-linear model analysis. Am. J. Hum. Genet. 48: 926-934.
44. Elnholm, C., H. Tenkanen, P. de Knijff, L. Havekes, M. Rosseneu, H. J. Menzel, and L. Tiret. 1994. Genetic polymorphism of apolipoprotein A-IV in five different regions of Europe. Relations to plasma lipoproteins and to history of myocardial infarction: the EARS study. European Atherosclerosis Research Study. Atherosclerosis. 107: 229-238.
45. von Eckardstein, A., H. Funke, M. Schulte, M. Erren, H. Schulte, and G. Assmann. 1992. Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apoB- and apoA-I-containing lipoproteins in a normal population. Am. J. Hum. Genet. 50: 1115-1128.
46. Zaiou, M., S. Visvikis, R. Gueguen, H. J. Parra, J. C. Fruchart, and G. Siest. 1994. DNA polymorphisms of human apolipoprotein A-IV gene: frequency and effects on lipid, lipoprotein and apolipoprotein levels in a French population. Clin. Genet. 46: 248-254.
47. von Eckardstein, A., H. Funke, A. Chirazi, C. Chen-Haudenschild, H. Schulte, R. Schönfeld, E. Köhler, S. Schwärz, A. Steinmetz., and G. Assmann. 1994. Sex-specific effects of the glutamine/histidine polymorphism in apoA-FV on HDL metabolism. Arterrioscler. Thromb. 14: 1114-1120.
48. Mata, P., J. M. Ordovas, J. Lopez Miranda, A. H. Lichtenstein, B. Clevidence, J. T. Judd, and E. J. Schaefer. 1994. ApoA-IV phenotype affects diet-induced plasma LDI. cholesterol lowering. Arterioscler. Thromb. 14: 884-891.
49. Menzel, H. J., E. Boerwinkle, S. Schragl-Will, and G. Utermann. 1988. Human apolipoprotein A-IV polymorphism: frequency and effect on lipid and lipoprotein levels. Hum. Genet. 79: 368-372.
50. Menzel, H. J., G. Sigurdsson, E. Boerwinkle, S. Schragl-Will, H. Dieplinger, and G. Utermann. 1990. Frequency and effect of human apolipoprotein A-IV polymorphism on lipid and lipoprotein levels in an Icelandic population. Hum. Genet. 84: 344-346.
51. Menzel, H. J., H. Dieplinger, G. Sandholzer, J. Karadi, G. Utermann, and A. Csasza. 1995. Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequences of two new variants. Hum. Mutat. 5: 58-65.
52. Visvikis, S., A. Steinmetz, E. Boerwinkle, R. Gueguen, M. M. Glateau, and G. Siest. 1989. Frequency and effects of the apolipoprotein A-IV polymorphism. Clin. Genet. 36: 435-441.
53. de Knijff, P., M. Rosseneu, U. Beisiegel, W. de Keersgieter, W. W. Frants, and L. M. Havekes. 1988. Apolipoprotein A-IV polymorphism and its effect on plasma lipid and apolipoprotein concentrations. J Lipid Res. 29: 1621-1627.
54. de Knijff, P., L. G. Johansson, M. Rosseneu, R. R. Frants, J. Jespersen, and L. Havekes. 1992. Lipoprotein profile of a Greenland Inuit population: influence of anthropometric variables, apoE and A4 polymorphism, and lifestyle. Arterioscler. Thromb. 12: 1371-1379.
55. Hanis, C. L., T. C. Douglas, and D. Hewett-Emmett. 1991. Apolipoprotein A-IV protein polymorphism: frequency and effects on lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas. Hum. Genet. 86: 323-325.
56. Kaprio, J., R. E. Ferrel, B. A. Kottke, M. I. Kamboh, and C. F. Sing. 1991. Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to cardiovascular disease. Arterioscler. Thromb. 11: 1330-1348.
57. Kamboh, M. I., R. F. Hamman, S. Iyengar, G. E. Aston, and R. E. Ferrell. 1991. Apolipoprotein A-IV polymorphism and its role in determining variation in lipoprotein-lipid, glucose and insulin levels in normal and non-insulin-dependent diabetic individuals. Atherosclerosis. 91: 25-34.
58. Tenkanen, H., and C. Enholm. 1992. Molecular basis for apoA-IV polymorphisms. Ann. Med. 24: 47-52.
59. Castelli, W. P. 1986. The triglyceride issue: a view from Framingham. Am. Heart. J. 112: 432-437.
60. Garrow, J. 1991. Importance of obesity. Br. Med. J. 303: 704-706.
61. Gerdes, C., R. M. Fisher, V. Nicaud, J. Boer, S. E. Humphries, P. J. Talmud, and O. Faergerman, on behalf of the EARS Group. 1997. Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations. Studies in the fasting and postprandial states: the European Atherosclerosis Research studies. Circulation. 96: 733-740.