Subchronic feeding study of antimony trioxide in rats

Journal of Applied Toxicology

Volumn 19, Issue 3, 1999, Pages 205-209

  Hext, P M ^a   Pinto, P J ^a   Rimmel, B A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Antimony trioxide; Dietary; Feeding; No effect level; Rats; Subchronic

Indexed keywords

ALKALINE PHOSPHATASE; ANTIMONY; ASPARTATE AMINOTRANSFERASE;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY GROWTH; CONTROLLED STUDY; DIET; FEMALE; FOOD INTAKE; GROWTH RATE; HEMATOLOGY; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING; URINALYSIS;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ANTIMONY; ASPARTATE AMINOTRANSFERASES; BODY WEIGHT; CHOLESTEROL; DIET; FEMALE; HEMATOLOGIC TESTS; MALE; RATS; RATS, WISTAR; TRIGLYCERIDES; URINALYSIS; WEIGHT GAIN;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0032930042     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199905/06)19:3<205::AID-JAT567>3.0.CO;2-X     Document Type: Article

References (14)

1. T. O. Llewellyn and E. Isaac, Antimony Quarterly, Mineral Industry Surveys, pp. 1-5 US Department of the Interior, Bureau of Mines, Washington, DC (1988).
2. M. Windholz (ed.), The Merck Index, 10th Edn, p. 104. Merck, Rahway, NJ (1983).
3. Anonymous, Antimony and compounds. In Documentation of the TLVs, pp. 32-34. American Conference of Governmental Occupational Hygienists, Cincinatti, OH (1978).
4. W. D. Watt, Chronic inhalation toxicity of antimony trioxide: validation of the threshold limit value. Ph D Thesis, Wayne State University, Detroit, MI (1983).
5. D. H. Groth, L. E. Stettler, J. R. Burg, W. M. Busey, G. C. Grant and L. Wong, Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. J. Toxicol. Environ. Health 18, 607-626 (1986).
6. P. E. Newton, H. F. Bolte, I. W. Daly, B. D. Pillsbury, J. B. Terril, R. T. Drew, R. Ben-Dyke, A. W. Sheldon and L. F. Rubin, Subchronic and chronic inhalation toxicity of antimony trioxide in the rat. Fundam. Appl. Toxicol. 22, 561-576 (1994).
7. P. Gross, J. H. U. Brown, M. L. Westrick, R. P. Srsic, N. L. Butler and T. F. Hatch, Toxicologic study of calcium halophosphate phosphors and antimony trioxide. Arch. Ind. Health 11, 473-478 (1955).
8. SAS Institute, SAS/STAT User's Guide, Version 6, 4th Edn, Vol. 2. SAS Institute, Cary, NC (1989).
9. T. M. Farber, Selection of a Maximum Tolerated Dose (MTD) in Oncogenicity Studies, Pesticide Assessment Guidelines Subdivision F, Report number 540-09-88-003. US Environmental Protection Agency, Office of Pesticide Programs. Research Triangle Park, NC (1987).
10. C. U. Dernehl, C. A. Nau and H. H. Sweets, Animal studies on the toxicity of inhaled antimony trioxide. J. Ind. Hyg. Toxicol 27, 256 (1945).
11. W. R. Bradley and W. G. Frederick, The toxicity of antimony. Ind. Med. (Ind. Hyg. Sect.) 2, 15-22 (1941).
12. N. Hiraoka, The toxicity and organ distribution of antimony after chronic administration to rats. J Kyoto Pref. Med. Coll. 95, 997-1017 (1986).
13. IARC, Antimony trioxide and antimony trisulphide. IARC Monogr Eval. Carcinogen. Risks Hum. 47, 291-305 (1989).
14. P. M. Hext, Current perspectives on particulate induced pulmonary tumours. Hum. Exp. Toxicol. 13, 700-715 (1994).