Submicron cationic emulsions as a new delivery system for oligonucleotides

Pharmaceutical Research

Volumn 16, Issue 1, 1999, Pages 30-36

  Teixeira, H ^a   Dubernet, C ^a   Puisieux, F ^a   Benita, S ^b   Couvreur, P ^a  

^a UNIV PARIS SUD   (France)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cationic emulsions; Oligonucleotides; Partitioning; Stearylamine

Indexed keywords

OCTADECYLAMINE; OLIGONUCLEOTIDE;

ARTICLE; CATION TRANSPORT; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TARGETING; DRUG UPTAKE; EMULSION; FLOCCULATION; FLUIDIZED BED; PRIORITY JOURNAL; ZETA POTENTIAL;

CATIONS; CULTURE MEDIA; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; MICROCHEMISTRY; MODELS, CHEMICAL; OLIGONUCLEOTIDES; PARTICLE SIZE; THYMIDINE MONOPHOSPHATE;

EID: 0032929942     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018806425667     Document Type: Article

References (15)

1. Y. Rojanasakul. Antisense oligonucleotide therapeutics: drug delivery and targeting. Adv. Drug Del. Rev. 18:115-131 (1996).
2. A. Thierry, A. Rahman, and A. Dritschilo. Overcoming multidrug resistance in human tumor cells using free and liposomally encapsulated antisense oligodeoxynucleotides. Biochem. Biophy. Res. Com. 190:952-960 (1993).
3. C. Chavany, T. Saison-Behmoaras, T. Le Doan F. Puisieux, P. Couvreur, and C. Hélène. Adsorption of oligonucleotides onto polyisohexylcyanoacrylate nanoparticles protects them against nucleases and increases their cellular uptake. Pharm. Res. 11:1370-1378 (1994).
4. 50 nanoparticles by complexation with structured oligopeptides. Drug Delivery 3:187-195 (1996).
5. O. Zelphati and F. C. Szoka Jr. Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm. Res. 13:1367-1372 (1996).
6. K. Lappalainen, A. Urtti, E. Söderling, I. Jääskeläinen, K. Syrjänen, and S. Syrjänen. Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells. Biochim. Biophys. Acta. 1196:201-208 (1994).
7. D. C. Litzinger, J. M. Brown, I. Wala, S. A. Kaufman, G. Y. Van, C. L. Farrel, and D. Collins. Fate of cationic liposomes and their complex with oligonucleotide in vivo. Biochim. Biophys. Acta 1281:139-149 (1996).
8. E. Elbaz, A. Zeevi, S. Klang, and S. Benita. Positively charged submicron emulsions - a new type of colloidal drug carrier. Int. J. Pharm. 96:R1-R6 (1993).
9. S. Klang, J. Frucht-Pery, A. Hoffman, and S. Benita. Physicochemical characterization and acute toxicity evaluation of a positively-charged submicron emulsion vehicle. J. Pharm. Pharmacol. 46:986-993 (1994).
10. I. Aynié, C. Vauthier, M. Foulquier, C. Malvy, E. Fattal, and P. Couvreur. Development of a quantitative polyacrylamide gel electrophoresis analysis using a multichannel radioactivity counter for the evaluation of oligonucleotide-bound drug carrier. Anal. Biochem. 240:202-209 (1996).
11. D. Korner, S. Benita, G. Albrecht, and A. Baszkin. Surface properties of mixed phospholipid-stearylamine monolayers and their interaction with a non-ionic surfactant (poloxamer). Colloids Surfaces 3:101-109 (1994).
12. M. Berton, S. Sixou, R. Kravtzoff, C. Dartigues, L. Imbertie, C. Allal, and G. Favre. Improved oligonucleotide uptake and stability by a new drug carrier, the supramolecular biovector. Biochim. Biophys. Acta 1355:7-19 (1997).
13. F. M. P. Wong, D. L. Reiner, and M. B. Bally. Cationic lipid binding to DNA: characterization of complex formation. Biochem. 35:5756-5763 (1996).
14. E. Fattal, C. Vauthier, I. Aynie, Y. Nakada, G. Lambert, C. Malvy, and P. Couvreur. Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides. J. Control. Rel. In press.
15. T. Hara, F. Liu, D. Liu, and L. Huang. Emulsion formulations as a vector for gene delivery in vitro and in vivo. Adv. Drug Del. Rev. 24:265-271 (1997).