Is initial dose titration of amlodipine worthwhile in patients with mild to moderate hypertension?

Current Medical Research and Opinion

Volumn 15, Issue 1, 1999, Pages 39-45

  Hayduk, K ^a   Adamczak, M ^a   Nowitzki, G ^a  

^a MARIEN HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Amlodipine; Antihypertensive treatment; Blood pressure; Dose titration

Indexed keywords

AMLODIPINE; ANTIHYPERTENSIVE AGENT; CALCIUM ANTAGONIST;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; CLINICAL TRIAL; DIASTOLIC BLOOD PRESSURE; EDEMA; FEMALE; HEADACHE; HEART RATE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; SINGLE BLIND PROCEDURE; SYSTOLIC BLOOD PRESSURE; TIME; TREATMENT OUTCOME;

EID: 0032929272     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/03007999909115172     Document Type: Article

References (10)

1. Cross, B. W., Kirby, M. G., Miller, S., Shah, S. H., Sheldon, D. M. and Sweeney, M. T. (1993). A multicentre study of the safety and efficacy of amlodipine in mild to moderate hypertension. Br. J. Clin. Pract., 47, 37-240.
2. Fowler, G., Webster, J., Lyons, D., Witte, K., Crichton, W. A., Jeffers, T. A., Wickham, E. A., Sanghera, S. S., Cornish, R. and Petrie, J. C. (1993). A comparison of amlodipine with enalapril in the treatment of moderate/ severe hypertension. Brit. J. Clin. Pharmacol., 35, 491-498.
3. Hoegholm, A., Winberg, N., Rasmussen, E., Nielsen P. E. and a Danish Multicentre Group (1995). Comparative effects of amlodipine and felodipine ER on office and ambulatory blood pressure in patients with mild to moderate hypertension. J. Human Hyperten., 9 (Suppl 1), S25-S28.
4. Lacourciere, Y., Poirier, L. and Provencher, P. (1993). Comparison of amlodipine and captopril in hypertension based on 24-hour ambulatory monitoring. J. Cardiovasc. Pharmacol., 22 (Suppl A), S20-S23.
5. Malacco, E., Leonetti, G., Santini, F. and Gnemmi, A. E. (1993). Comparison of a calcium antagonist and an angiotensin converting enzyme inhibitor in the treatment of elderly hypertensive patients. Curr. Ther. Res., 54, 695-702.
6. Mehta, J. L., Lopez, L. M., Vlachakis, N. D., Gradman, A. H., Nash, D. T., O'Connell, M. T., Garland, W. T. and Pickering, B. I. (1993). Double blind evaluation of the dose response relationship of amlodipine in essential hypertension. Am. Heart J., 125, 1704-1710.
7. Neaton, J. D., Grimm, J. R. H., Prineas, R. J., Stamler, J., Grandits, G. A., Elmer, P. J., Cutler, J. A., Flack, J. M., Schoenberger, J. A., McDonald, R., Lewis, C. E. and Liebson, P. R., for the Treatment of Mild Hypertension Study Research Group (1993). Treatment of mild hypertension study. Final results. JAMA, 270, 713-724.
8. Physicians Desk Reference, 48th edition (1994). Medical Economics Data Production Company, Montvale, New Jersey. Product information for amlodipine besylate. p. 1786.
9. SAS/STAT User's Guide Version 6, 4th edn (1989). SAS Institute Inc., Cary, N.C., Vol. 2, 1162-1165.
10. Schuirmann, D. J. (1987). A comparison of the two one-sided tests procedures and the power approach for assessing the equivalence of average bioavailability. J. Pharmac. Biopharma, 15, 657-680.