Antifibrinolytic therapy with tranexamic acid in cardiac operations

Vascular

Volumn 7, Issue 2, 1999, Pages 195-199

  Matsuzaki, K ^a   Matsui, K ^a   Tanoue, Y ^a   Nagano, I ^a   Haraguchi, N ^a   Tatewaki, H ^a  

^a MATSUYAMA RED CROSS HOSPITAL   (Japan)

Author keywords

postoperative blood loss; thrombin antithrombin III complexes; 2 plasmin inhibitor plasmin complexes

Indexed keywords

ALPHA 2 ANTIPLASMIN; THROMBIN ANTITHROMBIN COMPLEX; TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPLEX FORMATION; CONTINUOUS INFUSION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DRUG EFFICACY; FEMALE; FIBRINOLYSIS; GRAFT PATENCY; HEART SURGERY; HEART VALVE REPLACEMENT; HEMOSTASIS; HUMAN; INFUSION; MALE; OPERATION DURATION; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; TREATMENT OUTCOME;

AGED; ANTIFIBRINOLYTIC AGENTS; ANTIPLASMIN; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; FEMALE; HEMOSTASIS, SURGICAL; HUMANS; MALE; MIDDLE AGED; THROMBOLYTIC THERAPY; TRANEXAMIC ACID;

EID: 0032928727     PISSN: 17085381     EISSN: None     Source Type: Journal    
DOI: 10.1177/096721099900700209     Document Type: Article

References (15)

1. Stibbe J., Kluft C., Brommer E. J. P., et al, Enhanced fibrinolytic activity during cardiopulmonary bypass in open-heart surgery in man is caused by extrinsic (tissue-type) plasminogen activator. European Journal of Clinical Investigations, 1984, 14, 375–382.
2. De Haan J., Schönberger J., Haan J., et al, Tissue-type plasminogen activator and fibrin monomers synergistically cause platelet dysfunction during retransfusion of shed blood after cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery, 1993, 106, 1017–1023.
3. Nakajima H., A clinical study on hemostatic fluctuation during and after cardiopulmonary bypass using hemostatic molecular markers. Nippon Kyobu Geka Gakkai Zasshi [English Abstract], 1992, 40, 1987–1997.
4. Royston D., Bidstrup B. P., Taylor K. M., Sapsford R. N., Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet, 1987, 2, 1289–1291.
5. Van Oeveren W., Jansen N. J. G., Bidstrup B. P., et al, Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Annals of Thoracic Surgery, 1987, 44, 640–645.
6. Bidstrup B. P., Royston D., Sapsford R. N., et al, Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol). Journal of Thoracic and Cardiovascular Surgery, 1989, 97, 364–372.
7. Kawasuji M., Ueyama K., Sakakibara N., et al, Effect of low-dose aprotinin on coagulation and fibrinolysis in cardiopulmonary bypass. Annlas of Thoracic Surgery, 1993, 55, 1205–1209.
8. Yau T. M., Carson S., Weisel R. D., et al, The effect of warm heart surgery on postoperative bleeding. Journal of Thoracic and Cardiovascular Surgery, 1992, 103, 1155–1163.
9. Horrow J. C., Hlavacek J., Strong M. D., et al, Prophylactic tranexamic acid decreases bleeding after cardiac operations. Journal of Thoracic and Cardiovascular Surgery, 1990, 99, 70–74.
10. Nakashima A., Matsuzaki K., Fukumura F., et al, Tranexamic acid reduces blood loss after cardiopulmonary bypass ASAIO Journal, 1993, 39(1), 85–89.
11. Øvrum E., Holen E. Å., Abdelnoor M., et al, Tranexamic acid (Cyklokapron) is not necessary to reduce blood loss after coronary artery bypass operations. Journal of Thoracic and Cardiovascular Surgery, 1993, 105, 78–83.
12. Verstraete M., Clinical application of inhibitors of fibrinolysis Drug, 1985, 29, 236–261.
13. Bidstrup B. P., Harrison J., Royston D., et al, Aprotinin therapy in cardiac operations: A report on use in 41 cardiac centres in the United Kingdom. Annals of Thoracic Surgery, 1993, 55, 971–976.
14. Havel M., Teufelsbauer H., Knöbl P., et al, Effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation. Journal of Thoracic and Cardiovascular Surgery, 1991, 101, 968–972.
15. Cosgrove D. M., Heric B., Lytle B. W., et al, Aprotinin therapy for reoperative myocardial revascularization: A placebo-controlled study. Annals of Thoracic Surgery, 1992, 54, 1031–1038.