Chlamydia trachomatis and male infertility: Chlamydia-IgA antibodies in seminal plasma are C. trachomatis specific and associated with an inflammatory response

Journal of the European Academy of Dermatology and Venereology

Volumn 12, Issue 2, 1999, Pages 143-152

  Ochsendorf, F R ^a   Ozdemir K ^a   Rabenau, H ^a   Fenner, Th ^b   Oremek, R ^a   Milbradt, R ^a   Doerr, H W ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Laborpraxis   (Germany)

Author keywords

Asymptomatic genital infection; Chlamydia trachomatis; Male infertility

Indexed keywords

DNA;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; DNA DETERMINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEMINAL PLASMA;

ADULT; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; BACTERIURIA; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENITAL DISEASES, MALE; HUMANS; IMMUNOGLOBULIN A; INFERTILITY, MALE; INFLAMMATION; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; SEMEN;

EID: 0032928703     PISSN: 09269959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0926-9959(98)00150-0     Document Type: Article

References (46)

1. Purvis K, Christiansen E. Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility. Int J Androl 1993;16:1-13.
2. Bar-Chama N, Goluboff E, Fisch H. Infection and pyospermia in male infertility: is it really a problem? Urol Clin North America 1994;21:469-475.
3. Greendale GA, Haas ST, Holbrook K, Walsh B, Schachter J, Phillips RS. The relationship of Chlamydia trachomatis infection and male infertility. Am J Public Health 1993;83:996-1001.
4. Ruijs GJ, Kauer FM, Jager S, Schöder PF, Schirm J, Kremer J. Is serology of any use when searching for correlations between Chlamydia trachomatis infection and male infertility? Fertil Steril 1990;53:131-136.
5. Eggert-Kruse W, Gerhard I, Näher H, Tilgen W, Runnebaum B. Chlamydial infection - a female and/or male infertility factor? Fertil Steril 1990;53:1037-1043.
6. Sellers JW, Mahony JB, Chernesky MA, Rath DJ. Tubal factor infertility: an association with prior chlamydial infection and asymptomatic salpingitis. Fertil Steril 1988;49:451-457.
7. Witkin SS, Jeremias J, Grifo JA, Ledger WJ. Detection of Chlamydia trachomatis in semen by the polymerase chain reaction in male members of infertile couples. Am J Obstet Gynecol 1993;168:1457-1462.
8. Eggert-Kruse W, Rohr G, Demirakca T, et al., Chlamydial serology in 1303 asymptomatic subfertile couples. Hum Reprod 1997;12:1464-1475.
9. Wolff H, Neubert U, Zebhauser M, Bezold G, Korting HC, Meurer M. Chlamydia trachomatis induces an inflammatory response in the male genital tract and is associated with altered semen quality. Fertil Steril 1991;55:1017-1019.
10. Mardh PA, Colleen S, Sylwan J. Inhibitory effect on the formation of chlamydial inclusions in McCoy cells by seminal fluid and some of its components. Invest Urol 1980;17:510-513.
11. Berger RE, Alexander ER, Monda GD, Ansell J, McCormick G, Holmes KK. Chlamydia trachomatis as a cause of acute 'idiopathic' epididymitis. N Engl J Med 1978;298:301-304.
12. Krieger JN. Chronische urogenitale Infektionen des Mannes. Urologe A 1994;33:196-202.
13. Wolff H, Neubert U, Volkenandt M, et al., Detection of Chlamydia trachomatis in semen by antibody-enzyme immunoassay compared with polymerase chain reaction, antigen-eznzyme immunoassay and urethral cell culture. Fertil Steril 1994;62:1250-1254.
14. Dieterle S, Mahony JB, Luinstra KE, Stibbe W. Chlamydial immunoglobulin Ig-G and Ig-A antibodies in serum and semen are associated with the presence of Chlamydia trachomatis DNA or rRNA in semen from male partners of infertile couples. Hum Reprod 1995;10:315-319.
15. Weidner W, Floren E, Zimmermann O, Thiele D, Ludwig M. Chlamydial antibodies in semen: search for 'silent' chlamydial infections in asymptomatic andrological patients. Infection 1996;24:309-314.
16. Ochsendorf FR, Rabenau H, Schöfer H, et al. Chlamydia trachomatis: Epidemiologie und Wertigkeit der serologischen Labordiagnostik. Z Hautkr 1991;66:878-882.
17. Grayston JG, Campbell LA, Kuo CC, et al. A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 1990;161:618-625.
18. Moss TR, Darougar S, Woodland RM, Nathan M, Dines RJ, Cathrine V. Antibodies to chlamydia species in patients attending a genitourinary clinic and the impact of antibodies to C. pneumoniae and C. psittaci on the sensitivity and the specificity of C. trachomatis serology tests. Sex Transmitted Dis 1993;20:61-65.
19. Dieterle S, Mesrogli M, Triebler B, Wollenhaupt J, Netteln-breker E, Schlöfler HW. Is there a relationship between occlusions of the fallopian tubes with chronic salpingitis and urogenital chlamydial infections? Geburtsh Frauenheilk 1994;54:455-459.
20. Kojima H, Wang SP, Kuo CC, Grayston JT. Local antibody in semen for rapid diagnosis of Chlamydia trachomatis epididymitis. J Urol 1988;140:528-531.
21. Tomasi TB, Grey HM. Structure and function of immunoglobulin A. Progr Allergy 1972;16:81-213.
22. Treharne JD. Chlamydial serology. Br Med Bull 1983;39:194-200.
23. Witkin SS, Biogiovanni AM, Inglis SR. Detection of endocervical anti-Chlamydia trachomatis immunoglobulin A in pregnant women by a rapid 6-minute enzyme-linked immunosorbent assay: comparison with PCR and chlamydial antigen detection methods. J Clin Microbiol 1997;35:1781-1783.
24. Su H, Feilzer K, Caldwell HD, Morrison RP. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect Immun 1997;65:1993-1999.
25. Yoshida K, Kobayashi N, Negishi T. Chlamydia trachomatis infection in the semen of asymptomatic infertile men: detection of the antigen by in situ hybridization. Urol Int 1994;53:217-221.
26. Ludwig M, Hausmann G, Hausmann W, et al., Chlamydia trachomatis antibodies in serum and ejaculate of male patients without acute urethritis. Ann Urol 1996;30:139-146.
27. Munoz MG, Jeremias J, Witkin SS. The 60 kDA heat shock protein in human semen: relationship with antibodies to spermatozoa and Chlamydia trachomatis. Hum Reprod 1996; 11:2600-2603.
28. Näher H, Drzonek H, Wolf J, von Knebel Doebereitz M, Petzoldt D. Detection of C. trachomatis in urogenital specimens by polymerase chain reaction. Genitourin Med 1991;67:211-214.
29. Van den Brule AJC, Hemrika DJ, Walboomers JMM, Raaphorst P, van Amstel N, Bleker OP. Detection of Chlamydia trachomatis in semen of artificial insemination donors by the polymerase chain reaction. Fertil Steril 1993;59:1098-1104.
30. Fenner T, Fenner I, Kropec A, Fenner O. Detection of Chlamydia trachomatis in synovial fluid of patients with acute arthritis using polymerase chain reaction. 34th ICAAC, Annaheim, USA, 1992.
31. Sanders JW, Hook III EW, Welsh LE, Shepherd ME, Quinn TC. Evaluation of an enzyme immunoassay for detection of Chlamydia trachomatis in urine of asymptomatic men. J Clin Microbiol 1994;32:24-27.
32. Clad A, Freidank H, Plünnecke J, Jung B, Petersen EE. Chlamydia trachomatis species specific serology: ImmunoComb chlamydia bivalent versus microimmunofluorescence (MIF). Infection 1994;22:165-173.
33. World Health Organization. Laboratory Manual for the Examination of Human Semen and Cervical Mucus Interaction, third ed. Cambridge: The Press Syndicate, University of Cambridge, 1992.
34. Wolff H, Anderson DJ. Evaluation of granulocyte elastase as a seminal plasma marker for leukocytospermia. Fertil Steril 1988;50:129-132.
35. Taylor-Robinson D. Evaluation and comparison of tests to diagnose Chlamydia trachomatis genital infections. Hum Reprod 1997;12:113-120.
36. Lin JSL, Jones WE, Yan L, Wirthwein KA, Flaherty EE, Haivanis RM, Rice PA. Underdiagnosis of chlamyda trachomatis infection: diagnostic limitations in patients with low-level infection. Sex Transm Dis 1992;19:259-265.
37. Talbot H, Romanowski B. Factors affecting urine EIA sensitivity in the detection of Chlamydia trachomatis in men. Genitourin Med 1994;70:101-104.
38. Moncada J, Schachter J, Shafer MA, Williams E, Gourlay L, Lavin B, Bolan G. Detection of Chlamydia trachomatis in first catch urine samples from symptomatic and asymptomatic males. Sex Transm Dis 1994;21:8-12.
39. Nikkanen V, Terho P, Punnonen R, Meurman O. The significance of chlamydial genital infection in male infertility. Arch Androl 1980;4:57-61.
40. Bjerke S, Purvis K. Chlamydial serology in the investigation of infertility. Hum Reprod 1992;7:621-624.
41. Yong EC, Klebanoff SJ, Kuo CC. Toxic effect of human polymorphonuclear leukocytes on Chlamydia trachomatis. Infect Immun 1982;37:422-426.
42. Brunham RC, Kuo CC, Cles L, Holmes KK. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect Immun 1983;39:1491-1494.
43. Toye B, Laferriere C, Claman P, Jessamine P, Peeling R. Association between antibody to the chlamydial heat-shock protein and tubal infertility. J Infect Dis 1993;168:1236-1240.
44. Eckert LO, Hawes SE, Wolner-Hanssen P, et al., Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. J Infect Dis 1997;175:1453-1458.
45. Ochsendorf FR, Rabenau H. Chlamydienserologische Befunde bei andrologischen Patienten. In: Dreesbach, K (editor), Chlamydienserologie bei urogenitalen Infektionen des Mannes. Hamburg, Mahler, 1994;35-39.
46. Witkin SS. Circulating antibodies to Chlamydia trachomatis in women: relationship to antisperm and antichlamydial antibodies in semen of male partners. Hum Reprod 1996;11:1635-1637.