Altered activity of heme biosynthesis pathway enzymes in individuals chronically exposed to arsenic in Mexico

Archives of Toxicology

Volumn 73, Issue 2, 1999, Pages 90-95

  Hernández Zavala, Araceli ^a   Del Razo, Luz M ^a   García Vargas, Gonzalo G ^a   Aguilar, Carolina ^a   Borja, Victor H ^a   Albores, Arnulfo ^a   Cebrián, Mariano E ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Arsenic; Chronic exposure; Porphobilinogen deaminase; Porphyrins; Uroporphyrinogen decarboxylase

Indexed keywords

ARSENIC;

ARTICLE; CLINICAL ARTICLE; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; HEME SYNTHESIS; HUMAN; MEXICO; PRIORITY JOURNAL; TOXIN ANALYSIS;

ARSENIC; CREATININE; ENVIRONMENTAL EXPOSURE; ENZYMES; FEMALE; FLUORIDES; HEME; HUMANS; HYDROXYMETHYLBILANE SYNTHASE; MALE; MEXICO; PORPHYRINS; TIME FACTORS; UROPORPHYRINOGEN DECARBOXYLASE;

EID: 0032928575     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050592     Document Type: Article

References (20)

1. Agency for Toxic Substances and Disease Registry (ATSDR) (1993) Toxicological Profile for Arsenic. US Public Health Service, Atlanta, Ga
2. Cebrián ME, Albores A, Connelly JC, Bridges JW (1988) Assessment of arsenic effects on cytosolic heme status using tryptophan pyrrolase as an index. J Biochem Toxicol 3: 77-86
3. Cox DH (1980) Arsine evolution - Electrothermal atomic absorption method for the determination of nanogram levels of total arsenic in urine and water. J Analy Toxicol 4: 207-211
4. Crecelius EA, Bloom NS, Cowan CE, Jenne EA (1986) Arsenic Speciation. In Speciation of Selenium and Arsenic in Natural Waters and Sediments, vol 2. Battelle, Pacific Northwest Laboratories, California
5. Del Razo LM, Arellano MA, Cebrián ME (1990) The oxidation states of arsenic in well water from chronic arsenicism area northern Mexico. Environ Pollut 64: 143-153
6. Doss M (1979) Chronic hepatic porphyria in humans (endogenic factors). In: Strik JJTWA, Koeman JH (eds) Chemical Porphyria in Man. Elsevier/North-Holland Biomedical Press, Amsterdam, p 11
7. García-Vargas GG, Del Razo LM, Cebrián ME, Albores A, Ostrosky-Wegman P, Montero R, Gonsebatt ME, Lim C, De Matteis F (1994) Altered urinary porphyrin excretion in a human population chronically exposed to arsenic in Mexico. Hum Exp Toxicol 13: 839-847
8. García-Vargas GG, Cebrián ME, Albores A, Lim CK, De Matteis F (1995) Time-dependent porphyric response in mice subchronically exposed to arsenic. Hum Exp Toxicol 14: 475-483
9. Lim CK, Li F, Rideout JM, Wright DJ, Peters TJ (1986) Assaying erythrocyte haem biosynthetic enzyme activities by high performance liquid chromatography with the advanced automated sample processor. J Chromatogr 371: 293-298
10. Marks GS (1985) Exposure to toxic agents: The heme biosynthetic pathway and hemoproteins as indicator. CRC Crit Rev Toxicol 15: 151-179
11. Orion Research (1983) Fluoride Electrodes. Instruction Manual, form IM 94,96/3821, Cambridge, Mass.
12. SAS Institute (1994) SAS language and procedures, version 6, 4th edn. Cary, N.C.
13. Telolahy P, Javelaud B, Cluet J, de Ceaurriz J, Boudene C (1993) Urinary excretion of porphyrins by smelters workers chronically exposed to arsenic dust. Toxicol Lett 66: 89-95
14. USEPA (1979) Methods for Chemical Analysis of Water Wastes. Fluoride. Environmental Protection Agency (EPA-600 4-79020), Cincinnati, pp 340-342
15. Woods JS, Fowler B (1978) Altered regulation of mammalian hepatic heme biosynthesis and urinary porphyrin excretion during prolonged exposure to sodium arsenate. Toxicol Appl Pharmacol 43: 361-371
16. Woods JS, Southern M (1989) Studies on the etiology of trace metal-induced porphyria. Effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney. Toxicol Appl Pharmacol 97: 183-190
17. Woods JS, Kardish R, Fowler B (1981) Studies on the action of porphyrinogenic trace metals on the activity of hepatic uroporphyrinogen decarboxylase. Biochem Biophys Res Commun 103: 264-271
18. World Health Organization (WHO) (1981) Arsenic. Environ Health Criteria 18
19. Wright DJ, Lim CK (1983) Simultaneous determination of hydroxymethylbilane synthase and uroporphyrinogen III synthase in erythrocytes by high-performance liquid chromatography. Biochem J 213: 85-88
20. Vahter M, Lind B (1986) Concentrations of arsenic in urine of the general population in Sweden. Sci Total Environ 54: 1-12