Protection against Fasciola hepatica in the intestine is highly correlated with eosinophil and immunoglobulin G1 responses against newly excysted juveniles

Parasite Immunology

Volumn 21, Issue 5, 1999, Pages 243-251

  Van Milligen, Florine J ^a   Cornelissen, Jan B W J ^a   Bokhout, Ben A ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

F. hepatica; Immune responses; Protection; Rat Gut

Indexed keywords

IMMUNOGLOBULIN G1; PARASITE ANTIBODY;

ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FASCIOLA HEPATICA; FASCIOLIASIS; FEMALE; IMMUNOHISTOCHEMISTRY; MAST CELL; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; CATTLE; COLONY COUNT, MICROBIAL; EOSINOPHILS; FASCIOLA HEPATICA; FEMALE; IMMUNITY, MUCOSAL; INTESTINES; MAST CELLS; RATS; RATS, INBRED LEW; RATS, WISTAR; SPECIFIC PATHOGEN-FREE ORGANISMS;

ANIMALIA; FASCIOLA HEPATICA; HEPATICA; TREMATODA;

EID: 0032928005     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1999.00226.x     Document Type: Article

References (43)

1. Alizadeh H., Urban J.F., Katona I.M. & Finkelman F.D. (1986) Cells containing IgE in the intestinal mucosa of mice infected with the nematode parasite Trichinella spiralis are predominantly of a mast cell lineage. Journal of Immunology 137, 2555-2560
2. Andrew E.M. & Hall J.G. (1982) IgA antibodies in the bile of rats. I. Some characteristics of the primary response. Immunology 45, 169-175
3. Bexter A. (1982) 'Roulade'-technik/'Swiss-roll'-technik. Histochemistry 1, 12-13
4. Brouwer E., Weening J.J., Klok P.A. et al. (1993) Induction of an humoral and cellular (auto) immune response to human and rat myeloperoxidase (MPO) in Brown Norway (BN), Lewis and Wistar Kyoto (WKY) rat strains. In ANCA-Associated Vaculitides: Immunological and Clinical Aspects, ed W.L. Gross, p. 139-142, Plenum Press, NY.
5. Burden D.J., Bland A.P., Hughes D.L. & Hammet N.C. (1981) Fasciola hepatica: a technique for the study of gut penetration by juvenile flukes. Parasitology 83, 249-252
6. Burden D.J., Bland A.P., Hammet N.C. & Hughes D.L. (1983) Fasciola hepatica: migration of newly excysted juveniles in resistant rats. Experimental Parasitology 56, 277-288
7. Burden D.J., Hughes D.L. & Hammet N.C. (1982) Fasciola hepatica: antibody coating of juvenile flukes in the intestinal lumen of resistant rats. Research in Veterinary Science 32, 44-47
8. Capron M. & Capron A. (1986) Rats, mice and men - models for immune effector mechanisms against Schistosomiasis. Parasitology Today 2, 69-75
9. Charbon J.L., Spähni M. & Pfister K. (1991) Cellular reactions in the small intestine of rats after infection with Fasciola hepatica. Parasitology Research 77, 425-429
10. Cottrell B., Pye C. & Butterworth A. (1989) Cytotoxic effects in vitro of human monocytes and macrophages on schistosomula of Schistosoma mansoni. Parasite Immunology 11, 91-104
11. Davies C. & Goose J. (1981) Killing of newly excysted juveniles of Fasciola hepatica in sensitized rats. Parasite Immunology 3, 81-96
12. Doy T.G. & Hughes D.L. (1982) Evidence for two distinct mechanisms of resistance in the rat to reinfection with Fasciola hepatica. International Journal of Parasitology 12, 357-361
13. Doy T.G., Hughes D.L. & Harness E. (1978) Resistance of the rat to reinfection with Fasciola hepatica and the possible involvement of intestinal leucocytes. Research in Veterinary Science 25, 41-44
14. Doy T.G., Hughes D.L. & Harness E. (1981) Hypersensitivity in rats infected with Fasciola hepatica: possible role in protection against challenge infection. Research in Veterinary Science 30, 360-363
15. Duffus W.P.H. & Franks D. (1980a) In vitro effect of immune serum and bovine granulocytes on juvenile Fasciola hepatica. Clinical and Experimental Immunology 41, 430-440
16. Duffus W.P.H., Thorne K. & Oliver R. (1980b) Killing of juvenile Fasciola hepatica by purified bovine eosinophil proteins. Clinical and Experimental Immunology 40, 336-344
17. Else K.J., Entwistle G.M. & Grencis R.K. (1993) Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris. Parasite Immunology 15, 595-600
18. Gounni A.S., Lamkhioued B., Ochiai Y. et al. (1994) High-affinity receptor on eosinophils is involved in defence against parasites. Nature 367, 183-186
19. Hagan P. (1993) IgE and protective immunity to helminth infections. Parasite Immunology 15, 1-
20. Haroun E.M. & Hillyer G.V. (1986) Resistance to fascioliasis - a review. Veterinary Parasitology 20, 63-93
21. Hayes T.J. & Mitrovic M. (1977) The early expression of protective immunity to Fasciola hepatica in rats. Journal of Parasitology 63, 584-587
22. James S.L., Lazdins J.K., Hieny S. & Natovitz P. (1983) Macrophages as effector cells of protective immunity in murine schistosomiasis. Journal of Immunology 131, 1481-1486
23. Joseph M., Auriault C., Capron A., Vorng H. & Viens P. (1983) A new function for platelets: IgE-dependent killing of schistosomes. Nature 303, 810-812
24. Karlsson T., Ellerson J.R., Dahlbom I. & Bennich H. (1979) Analysis of the serum IgE levels in nonimmunized rats of various strains by a radioimmunoassay. Scandinavian Journal of Immunology 9, 217-228
25. Keegan P.S. & Trudgett A. (1992) Fasciola hepatica in the rat: immune responses associated with the development of resistance to infection. Parasite Immunology 14, 657-669
26. Khalife J., Capron M., Grzych J.-M., Bazin H. & Capron A. (1985) Extracellular release of rat eosinophil peroxidase. Journal of Immunology 134, 1968-74
27. Mayrhofer G., Bazin H. & Gowans J.L. (1976) Nature of cells binding anti-IgE in rats immunized with Nippostrongylus brasiliensis: IgE synthesis in regional nodes and concentration in mucosal mast cells. European Journal of Immunology 6, 537-545
28. Meeusen E. & Brandon M. (1994) The use of antibody-secreting cell probes to reveal tissue-restricted immune responses during infection. European Journal of Immunology 24, 469-474
29. Meeusen E., Lee C.S., Rickard M.D. & Brandon M.R. (1995) Cellular responses during liver fluke infection in sheep and its evasion by the parasite. Parasite Immunology 17, 37-45
30. Milbourne E.A. & Howell M.J. (1990) Eosinophil responses to Fasciola hepatica in rodents. International Journal for Parasitology 20, 705-708
31. Mulcahy G., O'Connor F., McGonogle S. et al. (1998) Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica. Vaccine 9-10, 932-939
32. O'Malley K.E., Sloan T. & Baird A.W. (1993) Type I hypersensitivity reactions in intestinal mucosae from rats infected with Fasciola hepatica. Parasite Immunology 15, 449-453
33. Orlans E., Peppard J., Reynolds J. & Hall J.G. (1978) Rapid active transport of immunoglobulin A from blood to bile. Journal of Experimental Medicine 147, 588-592
34. Orlans E., Peppard J.V., Payne A.W. et al. (1983) Comparative aspects of the hepatobiliary transport of IgA. Annual New York Academy of Sciences 409, 411-427
35. Poitou I., Baeza E. & Boulard C. (1993) Kinetic responses of parasite-specific antibody isotypes, blood leucocyte pattern and lymphocyte subsets in rats during primary infestation with Fasciola hepatica. Veterinary Parasitology 49, 179-190
36. Rajasekariah G.R. & Howell M.J. (1977) The fate of Fasciola hepatica metacercariae following challenge infection of immune rats. Journal of Helminthology 51, 289-294
37. Smith M.A. & Clegg J.A. (1981) Improved culture of Fasciola hepatica in vitro. Zeitschrift fur Parasitenkunde 66, 9-15
38. Vaerman J.P., Andre C., Bazin H. & Heremans J.F. (1973) Mesenteric lymph as major source of serum IgA in guinea pigs and rats. European Journal of Immunology 3, 580-584
39. Van Milligen F.J., Cornelissen J.B.W.J., Gaasenbeek C.P.H. & Bokhout B.A. (1998a) A novel ex vivo rat infection model to study protective immunity against Fasciola hepatica at the gut level. Journal of Immunological Methods 213, 183-190
40. Van Milligen F.J., Cornelissen J.B.W.J., Gaasenbeek C.P.H., Hendriks I.M. & Bokhout B.A. (1998b) Protection to Fasciola hepatica in the gut mucosa of immune rats is associated with infiltrates of cosinophils, IgG1 and IgG2a antibodies around the parasites. Parasite Immunology 20, 285-292
41. Wedrychowicz H.Z., Maclean J.M. & Holmes P.H. (1985) Some observations on a possible role of lung and faecal IgA antibodies in immunity of rats to Nippostrongylus brasiliensis. Journal of Parasitology 71, 62-69
42. Wedrychowicz H.Z. & Turner K. (1987) Antibody isotypes involved in local and systemic humoral responses of rats to primary and secondary infection with Fasciola hepatica. Acta Parasitologica Polonica 32, 369-382
43. Wicki P., Schwalbach B., Charbon J.L. et al. (1991) Intestinal cellular reactions in cattle after infection with Fasciola hepatica. Schweizer Archiv für Tierheilkunde 133, 429-437