Multiple intracellular pathways for regulation of chloride secretion in cultured pig tracheal submucosal gland cells

European Respiratory Journal

Volumn 13, Issue 3, 1999, Pages 571-576

  Zhang, A L ^a   Roomans, G M ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Airway submucosal gland; Chloride secretion; Conductance regulator; Cystic fibrosis transmembrane; Cytosolic free calcium concentration; Nucleotide; X ray microanalysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CALCIUM; CYCLIC AMP; IONOMYCIN; OLIGONUCLEOTIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CYSTIC FIBROSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; MEMBRANE PERMEABILITY; MICROANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; X RAY MICROANALYSIS;

EID: 0032927490     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.99.13357199     Document Type: Article

References (31)

1. Knowles MR, Stutts MJ, Spock A, Fisher N, Gatzy JT, Boucher RC. Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science 1983; 221: 1067-1070.
2. Widdicombe JH, Welsh MJ, Finkbeiner WE. Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium. Proc Natl Acad Sci USA 1985; 82: 6167-6171.
3. + transport in cystic fibrosis respiratory epithelia: abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 1986; 78: 1245-1252.
4. + permeability in cystic fibrosis human primary cell cultures. J Physiol Lond 1988; 405: 77-103.
5. Quinton PM. Chloride impermeability in cystic fibrosis. Nature 1983; 301: 421-422.
6. Riordan JR, Rommens JM, Kerem BS, et al. Identification of the cystic fibrosis gene: cloning and characterisation of complementary DNA. Science 1989; 245: 1066-1072.
7. Bear CE, Li CH, Kartner N, et al. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR). Cell 1989; 68: 809-818.
8. Engelhardt JF, Yankaskas JR, Ernst SA, et al. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet 1992; 2: 240-248.
9. Sorscher EJ, Kirk KL, Weaver ML, Jilling T, Blalock E, LeBoeuf RD. Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells. Proc Natl Acad Sci USA 1991; 88: 7759-7762.
10. Wagner JA, McDonald TV, Nghiem PT, et al. Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride current. Proc Natl Acad Sci USA 1992; 89: 6785-6789.
11. Frizzell RA, Rechkemmer G, Shoemmaker RL. Altered regulation of airway epithelial cell chloride channels in cystic fibrosis. Science 1986; 233: 558-560.
12. Boucher RC, Cheng EHC, Paradiso AM, Stutts MJ, Knowles MR, Earp HS. Chloride secretory response of cystic fibrosis human airway epithelia. J Clin Invest 1989; 84: 1424-1431.
13. Knowles MR, Clarke LL, Boucher RC. Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis. N Engl J Med 1991; 325: 533-538.
14. Mason SJ, Paradiso AM, Boucher RC. Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium. Br J Pharmacol 1991; 103: 1649-1656.
15. Bennett WD, Olivier KN, Zeman KL, Hohneker KW, Boucher RC, Knowles MR. Effect of uridine 5′-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis. Am J Respir Crit Care Med 1996; 153: 1796-1801.
16. Zhang AL, Roomans GM. Ion transport in cultured pig tracheal submucosal gland acinar cells studied by X-ray microanalysis. Eur Respir J 1997; 10: 2204-2209.
17. Jaskulski D, Deriel JK, Mercer WE, Calabretta B, Baserga R. Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science 1988; 240: 1544-1546.
18. Thierry AR, Dritschilo A. Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity. Nucleic Acids Res 1992; 20: 5691-5698.
19. Cazenave C, Claude H. Antisense oligonucleotides. In: Mol JNM, Krol AR, eds. Antisense Nucleic Acids and Proteins. New York/ Basel, Marcel Dekker, 1991; pp. 47-93.
20. Roomans GM. Quantitative X-ray microanalysis of biological specimens. J Electr Microsc Techn 1988; 9: 19-44.
21. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-3450.
22. Zhang AL, Martinez JR, Roomans GM. Effects of cholinergic and α-adrenergic agonists on the monovalent ion content of rat submandibular gland acinar cells studied by X-ray microanalysis. Histochem Cell Biol 1997; 108: 149-153.
23. Culp DJ, Lee DKP, Penney DP, Marin MG. Cat tracheal gland cells in primary culture. Am J Physiol 1992; 261: L264-L275.
24. Yamaya M, Finkbeiner WE, Widdicombe JH. Ion transport by cultures of human tracheobronchial submucosal glands. Am J Physiol 1991; 261: L485-L490.
25. Yang CM, Parley JM, Dwyer TM. Acetylcholine-stimulated chloride flux in tracheal submucosal gland cells. J Appl Physiol 1988; 65: 1891-1894.
26. Sasaki T, Shimura S, Wakui M, Ohkawara Y, Takishima T, Mikoshiba K. Apically localized IP3 receptors control chloride current in airway gland acinar cells. Am J Physiol 1994; 267: L152-L158.
27. McCann JD, Bhalla RC, Welsh MJ. Release of intra-cellular calcium by two different second messengers in airway epithelium. Am J Physiol 1989; 257: L116-L124.
28. Snouwaert JN, Brigman KK, Latour AM, et al. An animal model for cystic fibrosis made by gene targeting. Science 1992; 57: 1083-1088.
29. Yamaya M, Finkbeiner WE, Widdicombe JH. Altered ion transport by tracheal glands in cystic fibrosis. Am J Physiol 1991; 261: L491-L494.
30. Yamaya M, Sekizawa K, Kakuta Y, Ohrui T, Sawai T, Sasaki H. P2u-purinoceptor regulation of chloride secretion in cultured human tracheal submucosal glands. Am J Physiol 1996; 270: L979-L984.
31. Shimura S, Sasaki T, Nagaki M, Takishima T, Shirato K. Extracellular ATP regulation of feline tracheal submucosal gland secretion. Am J Physiol 1994; 267: L159-L164.