Design and synthesis of simplified sordaricin derivatives as inhibitors of fungal protein synthesis

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 1, 1999, Pages 103-108

  Cuevas, Juan C ^a   Lavandera, José L ^a   Martos, José L ^a  

^a GLAXOSMITHKLINE   (Spain)

Author keywords

Antibiotics; Enzyme inhibitors; Fungi; Molecular modeling mechanics

Indexed keywords

ANTIFUNGAL AGENT; SORDARICIN DERIVATIVE; SORDARIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; GEOMETRY; INHIBITION KINETICS; MOLECULAR MODEL; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; REDUCTION;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BIOLOGICAL AVAILABILITY; CANDIDA ALBICANS; CELL-FREE SYSTEM; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FUNGAL PROTEINS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN SYNTHESIS INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

FUNGI;

EID: 0032927236     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00693-3     Document Type: Article

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