Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch

International Journal of Pharmaceutics

Volumn 177, Issue 1, 1999, Pages 7-14

  Tsutsumi, Keiko ^a   Obata, Yasuko ^a   Takayama, Kozo ^a   Isowa, Koichi ^b   Nagai, Tsuneji ^a  

^a HOSHI UNIVERSITY   (Japan)

^b Center of Japan Biological Chemistry   (Japan)

Author keywords

Buccal permeation; Keratinized epithelial free membrane; Pathological study

Indexed keywords

AMINOPHENAZONE; CAFFEINE; IBUPROFEN; INDOMETACIN; LIDOCAINE; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CHEEK MUCOSA; CHEEK POUCH; DRUG ABSORPTION; DRUG PENETRATION; HAMSTER; LIPOPHILICITY; MALE; MEMBRANE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL;

ANIMALS; CHEEK; CRICETINAE; EPITHELIUM; KERATINS; MALE; MOUTH MUCOSA; PERMEABILITY; SOLUBILITY;

EID: 0032927054     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00329-9     Document Type: Article

References (15)

1. Baumberger J. P., Suntzeff V., Cowdry E. V. Methods for the separation of epidermis from dermis and some physiologic and chemical properties of isolated epidermis. J. Natl. Cancer Inst. 2:1942;413-423.
2. de Vries M. E., Bodde H. E., Verhoef J. C., Ponec M., Craane W. I. H. M., Junginger H. E. Localization of the permeability barrier inside porcine buccal mucosa: a combined in vitro study of drug permeability electrical resistance and tissue morphology. Int. J. Pharm. 76:1991;25-35.
3. Flynn G. L., Yalkowsky S. H. Correlation and prediction of mass transport across membranes I: influence of alkyl chain length on flux-determining properties of barrier and diffusant. J. Pharm. Sci. 61:1972;838-852.
4. Higuchi T. Physical chemical analysis of percutaneous absorption process from creams and ointment. J. Soc. Cosm. Chem. 11:1960;85-97.
5. Hoogstraate A. J., Verhoef J. C., Tuk B., Pijpers A, Van Leengoed L A. M. G., Verheijden J. H. M., Junginger H. E., Bodde H. E. In-vivo buccal delivery of fluorescein isothiocyanate-dextran 4400 with glycodeoxycholate as an absorption enhancer in pigs. J. Pharm. Sci. 85:1996;457-460.
6. Ishida M., Nambu N., Nagai T. Pharmaceutical interactions in dosage forms and processing. X X X V. Ointment-type oral mucosal dosage form of Carbopol containing prednisolone for treatment of aphtha. Chem. Pharm. Bu1l. 31:1983;1010-1014.
7. Kubo H., Hosoda K, Natsume H., Sugibayashi K, Morimoto Y. Evaluation of insulin permeation across the rabbit nasal mucosa using the Ussing chamber system. Drug Delivery System. 8:1993;461-465.
8. Kurosaki Y., Takatori T., Nishimura H., Nakayama T., Kimura T. Regional variation in oral mucosal drug absorption: permeability and degree of keratinization in hamster oral cavity. Pharm. Res. 8:1991;1297-1301.
9. Maitani Y., Ishigaki K., Takayama K., Nagai T. In vitro nasal transport across rabbit mucosa: effect of oxygen bubbling, pH and hypertonic pressure on permeability of lucifer yellow, diazepam and 17β-estradiol. Int. J. Pharm. 146:1997;11-19.
10. Reid C. O., Hardcastle J., Smith C. J. A comparison of some of the permeability characteristics of intact and tape-stripped hamster cheek pouches in vitro. J. Dent. Res. 65:1986;673-676.
11. Scott R. C., Walker M., Dugard P. H. In vitro percutaneous absorption experiments: a technique for the production of intact epidermal membranes from rat skin. J. Soc. Cosm. Chem. 37:1986;35-41.
12. Tanaka M., Yanagibashi N., Fukuda H., Nagai T. Absorption of salicylic acid through the oral mucous membrane of hamster cheek pouch. Chem. Pharm. Bull. 28:1980;1056-1061.
13. Taylan B., Capan Y., Guven O., Kes S., Hincal A. A. Design and evaluation of sustained-release and buccal adhesive propranolol hydrochloride tablets. J. Control. Release. 38:1996;11-20.
14. Tojo K, Chiang C. C., Chien Y. W. Drug permeation across the skin: effect of penetrant hydrophilicity. J. Pharm. Sci. 76:1987;123-126.
15. Voorspoels J., Remon J. P., Eechaute W., Sy W. D. Buccal absorption of testosterone and its esters using a bioadhesive tablet in dogs. Pharm. Res. 13:1996;1228-1232.