Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette-Guerin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

Clinical Science

Volumn 96, Issue 1, 1999, Pages 89-97

  Murphy, Colin ^a   Newsholme, Philip ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cytokines; L glutamine; Macrophages; Monocytes; Pancreatic cells

Indexed keywords

6 DIAZO 5 OXONORLEUCINE; BCG VACCINE; GLUTAMINASE; GLUTAMINE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE ACTIVATION; MALE; MONOCYTE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RNA TRANSLATION;

ANIMALS; CELL LINE; CELLS, CULTURED; COCULTURE TECHNIQUES; DIAZOOXONORLEUCINE; ENZYME INHIBITORS; EXTRACELLULAR SPACE; GLUTAMINASE; GLUTAMINE; HUMANS; INTERLEUKIN-8; ISLETS OF LANGERHANS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED STRAINS; MONOCYTES; MYCOBACTERIUM BOVIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032926387     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19980187     Document Type: Article

References (32)

1. 1 Loms Ziegler-Heitbrock, H. W. (1989) The biology of the monocyte system. Eur. J. Cell Biol. 49, 1
2. 2 Mehta, V., Hao, W., Brookes-Worrell, B. M. and Palmer, J. P. (1993) The functional state of the β-cell modulates IL-1 and TNF induced cytotoxicity. Lymphokine Cytokine Res. 12, 255-259
3. 3 Hanninen, A., Jalkanen, S., Salmi, M., Toikkanen, S., Nikolakaros, G. and Simell, O. (1992) Macrophages, T-cell receptor usage and endothelial cell activation in the pancreas at the onset of IDDM. J. Clin. Invest. 90, 1901-1910
4. 4 Krebs, H. (1981) Special Lecture: Glutamine metabolism in the animal body. In Glutamine: Metabolism, Enzymology and Regulation (Mora, J. and Palacios, R., eds.), pp. 319-325, Academic Press, New York
5. 5 Ardawi, M. S. M. and Newsholme, E. A. (1982) Maximum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ketone-body and glutamine utilization pathways in lymphocytes of the rat. Biochem. J. 201, 743-748
6. 6 Ardawi, M. S. M. and Newsholme, E. A. (1985) Metabolism in lymphocytes and its importance in the immune response. Essays Biochem. 21, 1-44
7. 7 Newsholme, P., Curi, R., Gordon, S. and Newsholme, E. A. (1986) Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem. J. 239, 121-125
8. 8 Newsholme, P., Gordon, S. and Newsholme, E. A. (1987) Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by murine macrophages. Biochem. J. 242, 631-636
9. 9 Newsholme, P. and Newsholme, E. A. (1989) Rates of utilization of glucose, glutamine and oleate and formation of end products by mouse peritoneal macrophages in culture. Biochem. J. 261, 211-218
10. 10 Zielke, H. R., Sumbilla, C. M., Zielke, C. L. et al. (1984) Glutamine metabolism by cultured mammalian cells. In Glutamine Metabolism in Mammalian Tissues (Haussinger, D. and Sies, H., eds.), pp. 247-254, Springer-Verlag, Berlin
11. 11 Reitzer, L. J., Wice, B. M. and Kenneil, D. (1979) Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254, 2669-2676
12. 12 Moskovitz, B., Katz., Y., Singer, P., Nativ, O. and Rosenburg, B. (1994) Glutamine metabolism and utilization: relevance to major problems in health care. Pharm. Res. 30, 61-71
13. 13 Van Furth, R., Diesselhoff-den Dulk, M. M. C., Sluiter, W. et al. (1985) New perspectives on the kinetics of mononuclear phagocytes. In Mononuclear Phagocytes: Characteristics, Physiology and Function (Van Furth, R., ed.), Martinus Nijhoff, Dordrecht, The Netherlands
14. 14 Gordon, S. (1986) Biology of the macrophage. J. Cell. Sci. Suppl. 4, 267-286
15. 15 Newsholme, P., Costa Rosa, L. F. B. P., Newsholme, E. A. and Curi, R. (1996) The importance of fuel metabolism for macrophage function. Cell Biochem. Function 14, 1-10
16. 16 Wallace, C. and Keast, D. (1992) Glutamine Macrophage. Function Metab. 41, 2235-2241
17. 17 Yassad, A., Lavoinne, A., Bion, A., Daveau, M. and Husson, A. (1997) Glutamine accelerates interleukin-6 production by rat peritoneal macrophages in culture. FEBS Lett. 413, 81-84
18. 18 Pukel, C., Baquerizo, H. and Rabinovitch, A. (1988) Destruction of rat islet cell monolayers by cytokines: synergistic interactions of IFN, TNF, lymphotoxin and IL-1. Diabetes 37, 133-136
19. 19 Nakhooda, A. F., Like, A. A., Chappel, C. I., Murray, F. T. and Marliss, E. B. (1976) The spontaneously diabetic Wistar rat. Diabetes 26, 100-112
20. 20 McClenaghan, N. H., Barnett, C. R., Ah-Sing, E. et al. (1996) Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. Diabetes 45, 1132-1140
21. 21 Standiford, T. J., Strieter, R. M., Allen, R. M., Burdick, M. D. and Kunkel, S. L. (1992) IL-7 up-regulates the expression of IL-8 from resting and stimulated human blood monocytes. J. Immunol. 149, 2035-2039
22. 22 Willeaume, V., Kruys, V., Mijatovic, T. and Huez, G. (1995) Tumour necrosis factor-alpha production induced by viruses and by lipopolysaccharides in macrophages: similarities and differences. J. Inflamm. 46, 1-12
23. 23 Newsholme, P. (1987) Studies on metabolism in macrophages. D. Phil Thesis, Oxford University
24. 24 Yoshimura, T., Matsushima, K., Tanaka, S. et al. (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that has sequence similarity to other host defence cytokines. Proc. Natl. Acad. Sci. U.S.A. 84, 9233
25. 25 Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N. and Williamson, B. (1975) An endotoxin-induced serum factor that causes necrosis of tumours. Proc. Natl. Acad. Sci. U.S.A. 72, 3666-3670
26. 26 Currie, G. A. (1978) Activated macrophages kill tumour cells by releasing arginase. Nature (London) 273, 758-759
27. 27 Parry-Billings, M., Evans, J., Calder, P. C. et al. (1990) Does glutamine contribute to immunosuppression after major burns? Lancet 336, 523-525
28. 28 Josefsen, K., Nielsen, H., Lorentzen, S., Damsbo, P. and Buschard, K. (1994) Circulating monocytes are activated in newly diagnosed type-1 diabetes mellitus patients. Clin. Exp. Immunol. 98, 489-493
29. 29 Bendtzen, K., Mandrup-Poulsen, T., Nerup, J., Neilsen, J. H., Dinarello, C. A. and Svenson, M. (1986) Cytotoxicity of human IL-1 for pancreatic islets of Langerhans. Science (Washington DC) 232, 1545-1547
30. 30 Mandrup-Paulsen, T., Bendtzen, K., Nerup, J., Dinarello, C. A., Svensen, M. and Nielsen, J. (1986) Affinity purified IL-1 is cytotoxic to isolated islets of Langerhans. Diabetologia 29, 63-67
31. 31 Dunger, A., Cunningham, J. M., Delany, C. A. et al. (1996) Tumour necrosis factor-α and interferon-β inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Diabetes 45, 183-189
32. 32 Murphy, C. and Newsholme, P. (1998) The importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production. Clin. Sci. 95, 397-407