HIV-1-induced neuronal injury in the developing brain

Journal of Leukocyte Biology

Volumn 65, Issue 4, 1999, Pages 453-457

  Epstein, Leon G ^a   Gelbard, Harris A ^b  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b NONE

Author keywords

Apoptosis; Blood brain barrier; Central nervous system; Neuroprotection; Pathogenesis

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ACETYLSALICYLIC ACID; ANTIOXIDANT; DIDANOSINE; GLUCOCORTICOID; GLUTAMATE RECEPTOR; INDOMETACIN; LEXIPAFANT; MATRIX METALLOPROTEINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SELEGILINE; THIOCTIC ACID; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA; ZIDOVUDINE;

ASTROCYTOSIS; BLOOD BRAIN BARRIER; CLINICAL FEATURE; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR MODEL; NERVE CELL LESION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SYNAPTOGENESIS; VIRUS CELL INTERACTION; VIRUS PATHOGENESIS;

EID: 0032925695     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.65.4.453     Document Type: Review

References (63)

1. Janssen, R. S., Cornblath, D. R., Epstein, L. G., Foa, R. P., McArthur, J. C., Price, R. W., Asbury, A. K., Beckett, A., Benson, D. F., Bridge, T. P., Leventhal, C. M., Satz, P., Saykin, A. J., Sidtis, J. J., and Tross, S. (1991) Nomenclature and research case dfinitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-I) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force. Neurol. 41, 778-785.
2. Epstein, L. G., Sharer, L. R., Oleske, J. M., Connor, E. M., Goudsmit, J., Bagdon, L., Robert-Guroff, M., Koenigsberger, M. R. (1986) Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics 78, 678-687.
3. Aylward, E. H., Henderer, J. D., McArthur, J. C., Brettschneider, P. D., Harris, G. J., Barta, P. E., Pearlson, G. D. (1993) Reduced basal ganglia volume in HIV-1-associated dementia: results from quantitative neuroimaging. Neurol. 43, 2099-2104.
4. Sharer, L. R. (1992) Pathology of HIV-1 infection of the central nervous system. A review. J. Neuropathol. Exp. Neurol. 51, 3-11.
5. Kozlowski, P. B., Brudkowska, J., Kraszpulski, M., Sersen, E. A., Wrzolek, M. A., Anzil, A. P., Rao, C., Wisniewski, H. M. (1997) Microencephaly in children congenitally infected with human immunodeficiency virus - a gross-anatomical morphometric study. Acta Neuropathol. 93, 136-145.
6. Saito, Y., Sharer, L. R., Epstein, L. G., Michaels, J., Mintz, M., Louder, M., Golding, K., Cvetkovich, T. A., Blumberg, B. M. (1994) Overexpression of Nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissue. Neurol. 44, 474-481.
7. Tornatore, C., Chandra, R., Berger, J., Major, E. (1994) HIV-1 infection of subcortical astrocytes in pediatric central nervous system. Neurol. 44, 481-487.
8. Wiley, C. A., Masliah, E., Morey, M., Lemere, C., DeTeresa, R., Grafe, M., Hansen, L., Terry, R. (1991) Neocortical damage during HIV infection. Ann. Neurol. 29, 651-657.
9. Weis, S., Haug, H., Budka, H. (1993) Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study. Acta Neuropathol. 85, 185-189.
10. Everall, I., Luthert, P., Lantos, P. (1993) A review of neuronal damage in human immunodeficiency virus infection: Its assessment, possible mechanism and relationship to dementia. J. Neuropathol. Exp. Neurol. 52, 561-566.
11. Gelbard, H. A., James, H. J., Sharer, L. R., Perry, S. W., Saito, Y., Kazee, A. M., Blumberg, B. M., Epstein, L. G. (1995) Identification of apoptotic neurons in post-mortem brain tissue from pediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol. Appl. Neurobiol. 21, 208-217.
12. Glass, J. D., Fedor, H., Wesselingh, S. L., McArthur, J. C. (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain. Ann. Neurol. 38, 755-762.
13. Michaels, J., Sharer, L. R., Epstein, L. G. (1988) Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: A review. Immunodef. Rev. 1, 42-77.
14. Wesselingh, S. L., Power, C., Glass, J. D., Tyor, W. R., McArthur, J. C., Farder, J. M., Griffin, J. W., Griffin, D. E. (1993) Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann. Neurol. 33, 576-582.
15. Sharer, L. R., Michaels, J., Murphey-Corb, M., Hu, F. S., Kuebler, D. J., Martin, L. N. (1991) Serial pathogenesis study of SIV brain infection. J. Med. Primatol. 20, 211-217.
16. Takahashi, K., Wesselingh, S. L., Griffin, D. E., McArthur, J. C., Johnson, R. T., Glass, J. D. (1996) Localization of HlV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann. Neurol. 39, 705-711.
17. Power, C., Kong, P. A., Crawford, T. O., Wesselingh, S., Glass, J. D., McArthur, J. C., Trapp, B. D. (1993) Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann. Neurol. 34, 339-350.
18. Genis, P., Jett, M., Bemton, E. W., Boyle, T., Gelbard, H. A., Dzenko, K., Keane, R. W., Resnick, L, Mizrachi, Y., Volsky, D. J., Epstein, L. G., Gendelman, H. E. (1992) Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophageastroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176, 1703-1718.
19. Giulian, D., Vaca, K., Noonan, C. A. (1990) Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250, 1593-1596.
20. Pulliam, L., Herndier, B. G., Tang, N. M., McGrath, M. S. (1991) HIV-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J. Clin. Invest. 87, 503-512.
21. Gelbard, H. A., Dzenko, K., Diloreto, D., Delcerro, C., Delcerro, M., Epstein, L. G. (1994) Neurotoxic effects of tumor necrosis factor in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: Implications for AIDS neuropathogenesis. Dev. Neurosci. 15, 418-422.
22. Gelbard, H. A., Nottet, H. S. L. M., Swindells, S., Jett, M., Dzenko, K. A., Genis, P., White, R., Wang, L., Choi, Y-B., Zhang, D., Lipton, S. A., Tourtellotte, W. W., Epstein, L. G., Gendelman, H. E. (1994) Platelet activating factor: a candidate HIV-1-induced neurotoxin. J. Virol. 68, 4628-4635.
23. Lipton, S. A. (1992) Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 3, 913-915.
24. New, D. R., Ma, M., Epstein, L. G., Nath, A., Gelbard, H. A. (1997) Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. J. Neurovirol. 3, 168-173.
25. Epstein, L. G., Gendelman, H. E. (1993) Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann. Neurol. 33, 429-436.
26. Albin, R. L., Greenamyre, J. T. (1992) Alternative excitotoxic hypotheses. Neurol. 42, 733-738.
27. Clark, G. D., Happel, L. T., Zorumski, C. F., Bazan, N. G. (1992) Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. Neuron 9, 1211-1216.
28. Fine, S. M., Angel, R. A., Perry, S. W., Epstein, L. G., Dewhurst, S., Gelbard, H. A. (1996) Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes: implications for pathogenesis of HIV-1 dementia. J. Biol. Chem. 271, 15303-15306.
29. Volterra, A., Troti, D., Cassutti, P., Tromba, C., Salvaggio, A., Melcangi, R. C. (1992) High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes. J. Neurochem. 59, 600-606.
30. Blumberg, B. M., Gelbard, H. A., Epstein, L. G. (1994) HIV-1 infection of the developing nervous system: central role of the astrocyte in pathogenesis. Virus Res. 32, 253-267.
31. Dawson, V. L., Dawson, T. M., Uhl, G. R., Snyder, S. H. (1993) Human immunodeficiency virus typl 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical neurons. Proc. Natl. Acad. Sci. USA 90, 3256-3259.
32. Talley, A. K., Dewhurst, S., Perry, S., Dollard, S. C., Gummuluru, S., Fine, S. M., New, D., Epstein, L. G., Gendelman, H. E., Gelbard, H. A. (1995) Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crm A. Mol. Cell. Biol. 15, 2359-2366.
33. Adle-Biassette, H., Levy, Y., Colombel, M., et al. (1995) Neuronal apoptosis in HIV infection in adults. Neuropathol. Appl. Neurobiol. 21, 218-227.
34. Petito, C. K., Roberts, B. (1995) Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol. 146, 1121-1130.
35. Dollard, S. C., James, H. J., Sharer, L. R., Epstein, L. G., Gelbard, H. G., Dewhurst, S. (1995) Activation of nuclear factor κB in brains from children with HIV-1 encephalitis. Neuropathol. Appl. Neurobiol. 21, 518-528.
36. Gray, F. Belec, L., Chretien, F., et al. (1998) Acute, relapsing brain oedema with difuse bood-brain barrier alteration and axonal damage in the acquired immunodeficiency syndrome. Neuropathol. Appl. Neurobiol. 24, 209-216.
37. Mintz, M., Rapaport, R., Oleske, J. M., Connor, E. M., Koenigsberger, M. R., Denny, T., Epstein, L. G. (1989) Elevated serum levels of tumor necrosis factors are associated with progressive encephalopathy in children with AIDS. Am. J. Dis. Child 143, 771-774.
38. Pizzi, M., Fallacara, C., Consolandi, O., Memo, M., Spano, P. F. (1994) α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate differently affect neuronal cytoarchitecture of rat cerebellar granule cells. Neurosci. Lett. 166, 77-80.
39. Kalb, R. G. (1994) Regulation of motor neuron dendrite outgrowth by NMDA receptor activation. Dev. 120, 3063-3071.
40. McDonald, J. W., Johnston, M. V. (1990) Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res. Rev. 15, 41-70.
41. Huttenlocher, P. R., de Couten, C. (1987) The development of synapses in striate cortex in man. Human Neurobiol. 6, 1-9.
42. Rakic, P., Bourgeois, J. P., Eckenhoff, M. F., Zecevic, N., Goldman-Rakic, P. S. (1986) Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. Science 232, 232-235.
43. Mattson, M. P., Kater, S. B. (1989) Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture. Brain Res. 478, 337-348.
44. Naidu, S. (1997) Rett Syndrome: A disorder affecting early brain growth. Ann. Neurol. 42, 3-10.
45. Bauman, M. L., Kemper, T. L., Arin, D. M. (1995) Pervasive neuroanatomical abnormalities of the brain in three cases of Rett Syndrome. Neurol. 45, 1581-1586.
46. Belichenko, P. V., Hagberg, B., Dahlstrom, A. (1997) Morphological study of neocortical areas in Rett syndrome. Acta Neuropathol. 93, 50-61.
47. Belman, A. L. (1992) AIDS and the child's central nervous system. Pediat. Clin. North Am. 39, 691-714.
48. Englund, J. A., Baker, C. J., Raskino, C., et al. (1997) Zidovudine, Didanosine, or both as the initial treatment for symptomatic HIV-infected children. N. Engl. J. Med. 336, 1704-1712.
49. Englund, J. A., Baker, C. J., Raskino, C., et al. (1996) Clinical and laboratory characteristics of a large cohort of symptomatic human immunodeficiency virus-infected infants and children. Pediat. Infect. Dis. 15, 1025-1036.
50. DeCarli, C., Fugate, L., Fallon, J., et al. (1991) Brain growth and cognitive improvement in children with human immunodeficieny virus-induced encephalopathy after 6 months of continuous infusion zidovudine therapy. J. AIDS 4, 585-592.
51. Chen, P., Mayne, M., Power, C., Nath, A. (1997) The Tat protein of HIV-1 induces tumor necrosis factor-alpha production, Implications for HIV-1-associated neurological diseases. J. Biol. Chem. 272, 22385-22388.
52. New, D. R., Maggirwar, S. B., Epstein, L. G., Dewhurst, S., Gelbard, H. A. (1998) HIV 1 Tat induces neuronal death via tumor necrosis factor alpha and activation of nonNMDA receptors by a NFκB-mdependent mechanism. J. Biol. Chem. 273, 17852-17858.
53. Perry, S. W., Dbaibo, G., Dzenko, K. A., Epstein, L. G., Hannan, Y., Whittaker, J. S., Dewhurst, S., Gelbard, H. A. (1998) PAF receptor activation: An initiator step in HIV-1 neuropathogenesis. J. Biol. Chem. 273, 17660-17664.
54. Namura, Y., Shio, H., Kimura, J. (1994) LTC4/LTB4 alterations in rat forebrain ischemia and reperfusion and effects of AA861, CV3988. Acta Neurochir. Suppl. Wien. 60, 296-299.
55. Liu, X. H., Eun, B. L. Silverstein, F. S., Barks, J. D. (1996) The platelet-activating factor antagonist BN 52021 attenuates hypoxicischemic brain injury in the immature rat. Pediat. Res. 40, 797-803.
56. Liedtke, W., Cannella, B., Mazzaecaro, R. J., et al. (1998) Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. Ann. Neurol. 44, 35-46.
57. Brooke, S., Chan, R., Howard, S., Sapolsky, R. (1997) Endocrine modulation of the neurotoxicity of gp120: implications for AIDS-related dementia complex. Proc. Natl. Acad. Sci. USA 9457-9462.
58. Persidsky, Y., Limoges, J., McComb, R., Bock, P., Baldwin, T., Tyor, W., Patil, A., Nottet, H. S. L. M., Epstein, L., Gelbard, H., Flanagan, E., Reinhard, S. J., Gendelman, H. E. (1996) A quantitative analysis of brain immunopathology in SCID mice with HIV-1 encephalitis. Am. J. Pathol. 149, 1027-1053.
59. Limoges, J., Persidsky, Y., Bock, P., Gendelman, H. E. (1997) Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. J. Infect. Dis. 175, 1368-1381.
60. Crawford, S. E., Stellmach, V., MurphyUllrich, J. E., et al. (1998) Thrombospondin-1 is a major activator of TGFbetal in vivo. Cell 93, 1159-1170.
61. Nottet, H. S. L. M., Jett, M., Flanagan, C. R., Zhai, Q. H., Persidsky, Y., Rizzino, A., Bernton, E. W., Genis, P., Baldwin, T., Schwartz, J., LaBenz, C. J., Gendelman, H. E. (1995) A regulatory role for astrocytes in HIV-1 encephalitis. J. Immunol. 154, 3567-3581.
62. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders (1997) Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. Neurol. 49, 142-146.
63. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders (1998) A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Neurol. 50, 645-651.